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UniProtKB/Swiss-Prot entry P02662


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CASA1_BOVIN
Primary accession number P02662
Secondary accession numbers A5YK80 A8WCP1 A8WCP2 A8WCP3 A8WCP4 A8WCP5 A8WCP6 A8WCP7 A8WCP8 A8WCP9 A8WCQ0 A8WCQ1 A8WCQ2 A8WCQ3 A8WCQ4 A8WCQ5 A8WCQ6 A8WCQ7 A8WCQ8 A8WCQ9 A8WCR0 A8WCR1 A8WCR2 A8WCR3 A8WCR4 A8WCR5 A8WCR6 A8WCR7 A8WCR8 A8WCR9 A8WCS0 A8WCS1 Q28048 Q28069 Q32LE8 Q7M2U6 Q9TRH5
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on November 1, 1990 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 82)
Name and origin of the protein
Protein name Alpha-S1-casein [Precursor]
Synonyms None
Contains Antioxidant peptide
Gene name
Name: CSN1S1
From
Bos taurus (Bovine) [TaxID: 9913] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1093/nar/12.9.3895; PubMed=6328443 [NCBI, ExPASy, EBI, Israel, Japan]
Stewart A.F., Willis I.M., Mackinlay A.G.;
"Nucleotide sequences of bovine alpha S1- and kappa-casein cDNAs.";
Nucleic Acids Res. 12:3895-3907(1984).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Nagao M., Maki M., Sasaki R., Chiba R.;
"Isolation and sequence analysis of bovine alpha-S1-casein cDNA clone.";
Agric. Biol. Chem. 48:1663-1667(1984).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Mammary gland;
PubMed=3022833 [NCBI, ExPASy, EBI, Israel, Japan]
Gorodetskii S.I., Zakhar'ev V.M., Kyarshulite D.R., Kapelinskaya T.V., Skryabin K.G.;
"cDNA of cattle alpha S1-casein: cloning and nucleotide sequence.";
Biokhimiia 51:1641-1648(1986).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1093/nar/19.20.5591; PubMed=1658736 [NCBI, ExPASy, EBI, Israel, Japan]
Koczan D., Hobom G., Seyfert H.-M.;
"Genomic organization of the bovine alpha-S1 casein gene.";
Nucleic Acids Res. 19:5591-5596(1991).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Schulmeister U., Hochwallner H., Swoboda I., Focke-Tejkl M., Geller B., Nystrand M., Harlin A., Thalhamer J., Scheiblhofer S., Keller W., Niggemann B., Quirce S., Ebner C., Mari A., Pauli G., Herz U., Valenta R., Spitzauer S.;
"Cloning, expression and mapping of allergenic determinants of alphaS1-casein, a major cow's milk allergen.";
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Crossbred X Angus;
TISSUE=Liver;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
[7]
PROTEIN SEQUENCE OF 16-214 (VARIANT B).
PubMed=4331376 [NCBI, ExPASy, EBI, Israel, Japan]
Mercier J.-C., Grosclaude F., Ribadeau-Dumas B.;
"Primary structure of bovine alpha-s1 casein. Complete sequence.";
Eur. J. Biochem. 23:41-51(1971).
[8]
SEQUENCE REVISION TO 74 AND 92-93 (VARIANTS A; B; C AND D).
PubMed=4797901 [NCBI, ExPASy, EBI, Israel, Japan]
Mercier J.-C., Grosclaude F., Ribadeau-Dumas B.;
"Primary structure of alpha casein and of bovine beta casein. Correction.";
Eur. J. Biochem. 40:323-323(1973).
[9]
PROTEIN SEQUENCE OF 16-214 (VARIANT D).
PubMed=5064450 [NCBI, ExPASy, EBI, Israel, Japan]
Grosclaude F., Mahe M.-F., Mercier J.-C., Ribadeau-Dumas B.;
"Characterization of genetic variants of alpha-S1 and beta bovine caseins.";
Eur. J. Biochem. 26:328-337(1972).
[10]
PROTEIN SEQUENCE OF 23-49 (VARIANT A).
DOI=10.1016/0014-5793(70)80504-X; PubMed=11945462 [NCBI, ExPASy, EBI, Israel, Japan]
Grosclaude F., Mahe M.-F., Mercier J.-C., Ribadeau-Dumas B.;
"Localization in the N-terminal part of bovine casein alpha-s1 of a 13 amino-acid deletion that differentiates variant A from variants B and C.";
FEBS Lett. 11:109-112(1970).
[11]
PROTEIN SEQUENCE OF 39-55.
TISSUE=Mammary gland;
DOI=10.1016/0014-5793(92)80664-3; PubMed=1299613 [NCBI, ExPASy, EBI, Israel, Japan]
Neuteboom B., Giuffrida M.G., Conti A.;
"Isolation of a new ligand-carrying casein fragment from bovine mammary gland microsomes.";
FEBS Lett. 305:189-191(1992).
[12]
PROTEIN SEQUENCE OF 39-47 AND 166-188.
DOI=10.1016/0167-4838(96)00103-3; PubMed=8841384 [NCBI, ExPASy, EBI, Israel, Japan]
Ramalho-Santos M., Verissimo P., Faro C., Pires E.;
"Action on bovine alpha s1-casein of cardosins A and B, aspartic proteinases from the flowers of the cardoon Cynara cardunculus L.";
Biochim. Biophys. Acta 1297:83-89(1996).
[13]
NUCLEOTIDE SEQUENCE [MRNA] OF 55-130.
PubMed=6897774 [NCBI, ExPASy, EBI, Israel, Japan]
Willis I.M., Stewart A.F., Caputo A., Thompson A.R., McKinlay A.G.;
"Construction and identification by partial nucleotide sequence analysis of bovine casein and beta-lactoglobulin cDNA clones.";
DNA 1:375-386(1982).
[14]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 85-110.
Shahla M.N., Farooq M.S., Naeem M.K., Riazuddin S.;
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
[15]
PROTEIN SEQUENCE OF 95-105, AND FUNCTION.
Gupta A., Mann B., Kumar R., Sangwan R.B.;
"Antioxidant peptides isolated from cheddar cheese made with adjunct culture L.casei ssp. casei 300.";
Submitted (MAR-2008) to UniProtKB.
[16]
NUCLEOTIDE SEQUENCE [MRNA] OF 122-214.
PubMed=3838718 [NCBI, ExPASy, EBI, Israel, Japan]
Kiarshulite D.R., Zakhar'ev V.M., Gorodetskii S.I.;
"Nucleotide sequence of the 3'-nontranslated region of the mRNA of alpha S1-casein in cows.";
Dokl. Akad. Nauk SSSR 280:1433-1437(1985).
[17]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 164-214.
PubMed=1343827 [NCBI, ExPASy, EBI, Israel, Japan]
Chen R., Wang B., Zhang Y., Liu W., Zhang J., Lao W.;
"Cloning, mapping, and sequencing of 3' and its flanking region of bovine alpha-s1 casein gene.";
Chin. J. Biotechnol. 8:235-245(1992).
[18]
NUCLEOTIDE SEQUENCE [MRNA] OF 185-202.
TISSUE=Mammary gland;
Maki M., Nagao M., Hirose M., Chiba H.;
"Cloning of cDNA sequence coding for bovine alpha-s1-casein.";
Agric. Biol. Chem. 47:441-444(1983).
[19]
PROTEIN SEQUENCE OF 205-214 (VARIANT C).
Grosclaude F., Mercier J.-C., Ribadeau-Dumas B.;
"On the localization in the C-terminal sequence of bovine casein alpha-s1 of a Glu/Gly substitution that differentiates the genetic variants B and C.";
C. R. Hebd. Seances Acad. Sci., D, Sci. Nat. 268:3133-3136(1970).
[20]
ERRATUM, AND SEQUENCE REVISION.
Grosclaude F., Mercier J.-C., Ribadeau-Dumas B.;
C. R. Hebd. Seances Acad. Sci., D, Sci. Nat. 271:563-563(1970).
[21]
PHOSPHORYLATION AT SER-56.
Bai F., Liu S., Witzmann F.A.;
Submitted (SEP-2005) to UniProtKB.
[22]
PHOSPHORYLATION AT SER-56; SER-61; SER-63; SER-79; SER-81; SER-82; SER-83; SER-90 AND SER-130, AND MASS SPECTROMETRY.
DOI=10.1074/mcp.M600480-MCP200; PubMed=17510049 [NCBI, ExPASy, EBI, Israel, Japan]
Imanishi S.Y., Kochin V., Ferraris S.E., de Thonel A., Pallari H.M., Corthals G.L., Eriksson J.E.;
"Reference-facilitated phosphoproteomics: fast and reliable phosphopeptide validation by micro LC-ESI-Q-TOF MS/MS.";
Mol. Cell. Proteomics 6:1380-1391(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X00564; CAB57792.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M33123; AAA30428.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M38641; AAA30429.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X59856; CAA42516.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221551; ABW98936.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221552; ABW98937.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221553; ABW98938.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221554; ABW98939.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221555; ABW98940.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221556; ABW98941.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221557; ABW98942.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221558; ABW98943.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221559; ABW98944.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221560; ABW98945.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221561; ABW98946.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221562; ABW98947.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221563; ABW98948.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221564; ABW98949.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221565; ABW98950.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221566; ABW98951.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221567; ABW98952.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221568; ABW98953.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221569; ABW98954.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221570; ABW98955.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221571; ABW98956.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221572; ABW98957.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221573; ABW98958.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221574; ABW98959.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221575; ABW98960.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221576; ABW98961.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221577; ABW98962.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221578; ABW98963.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221579; ABW98964.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221580; ABW98965.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU221581; ABW98966.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC109618; AAI09619.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
K01084; AAA30478.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EF538766; ABQ88318.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M38658; AAA62707.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S72388; AAD14099.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D00412; BAA00313.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S22575; KABOSB.
S72220; S72220.
RefSeq NP_851372.1; -.
UniGene Bt.59369
3D structure databases
DisProt DP00330; -.
ModBase P02662.
Ontologies
GO
GO:0016209; Molecular function: antioxidant activity (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001588; Casein.
Graphical view of domain structure.
Pfam PF00363; Casein; 1.
Pfam graphical view of domain structure.
PROSITE PS00306; CASEIN_ALPHA_BETA; 1.
BLOCKS P02662.
ProtoNet P02662.
Genome annotation databases
Ensembl ENSBTAG00000007695; Bos taurus. [Contig view]
GeneID 282208; -.
KEGG bta:282208; -.
Phylogenomic databases
HOVERGEN P02662; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Antioxidant; Direct protein sequencing; Milk protein; Phosphoprotein; Polymorphism; Repeat; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    15  15      
CHAIN   16   214  199     Alpha-S1-casein. PRO_0000004446
PEPTIDE   95   105  11     Antioxidant peptide. PRO_0000331578
REPEAT   85    99  15      
REPEAT   125   140  16      
MOD_RES   56    56        Phosphoserine. 
MOD_RES   61    61        Phosphoserine. 
MOD_RES   63    63        Phosphoserine. 
MOD_RES   68    68        Phosphothreonine; in variant D. 
MOD_RES   79    79        Phosphoserine. 
MOD_RES   81    81        Phosphoserine. 
MOD_RES   82    82        Phosphoserine. 
MOD_RES   83    83        Phosphoserine. 
MOD_RES   90    90        Phosphoserine. 
MOD_RES   130   130        Phosphoserine. 
VARIANT   29    41  13     Missing (in variant A). 
VARIANT   68    68  1     A -> T (in variant D). 
VARIANT   207   207  1     E -> G (in variant C). 
CONFLICT   11    12        AV -> SA (in Ref. 5; ABW98943). 
CONFLICT   42    42        P -> L (in Ref. 3; AAA30429). 
CONFLICT   44    44        P -> S (in Ref. 5; ABW98945). 
CONFLICT   95    95        H -> Q (in Ref. 13; AAA30478). 
CONFLICT   99    99        E -> D (in Ref. 14; ABQ88318). 
CONFLICT   143   143        H -> D (in Ref. 3; AAA30429). 
CONFLICT   171   171        L -> P (in Ref. 5; ABW98953). 
CONFLICT   203   203        S -> L (in Ref. 16; AAA62707). 
CONFLICT   211   212        MP -> IS (in Ref. 3; AAA30429). 
Sequence information
Length: 214 AA [This is the length of the unprocessed precursor] Molecular weight: 24529 Da [This is the MW of the unprocessed precursor] CRC64: F066B5C8AE55828B [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKLLILTCLV AVALARPKHP IKHQGLPQEV LNENLLRFFV APFPEVFGKE KVNELSKDIG 

        70         80         90        100        110        120 
SESTEDQAME DIKQMEAESI SSSEEIVPNS VEQKHIQKED VPSERYLGYL EQLLRLKKYK 

       130        140        150        160        170        180 
VPQLEIVPNS AEERLHSMKE GIHAQQKEPM IGVNQELAYF YPELFRQFYQ LDAYPSGAWY 

       190        200        210 
YVPLGTQYTD APSFSDIPNP IGSENSEKTT MPLW 

P02662 in FASTA format

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