[1]
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NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3680290 [NCBI, ExPASy, EBI, Israel, Japan]
Sasaki M.,
Yamada Y.;
"The laminin B2 chain has a multidomain structure homologous to the B1 chain.";
J. Biol. Chem. 262:17111-17117(1987).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1021/bi00414a038; PubMed=3167041 [NCBI, ExPASy, EBI, Israel, Japan]
Durkin M.E.,
Bartos B.B.,
Liu S.-H.,
Phillips S.L.,
Chung A.E.;
"Primary structure of the mouse laminin B2 chain and comparison with laminin B1.";
Biochemistry 27:5198-5204(1988).
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[3]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-239.
PubMed=2836421 [NCBI, ExPASy, EBI, Israel, Japan]
Ogawa K.,
Burbelo P.D.,
Sasaki M.,
Yamada Y.;
"The laminin B2 chain promoter contains unique repeat sequences and is active in transient transfection.";
J. Biol. Chem. 263:8384-8389(1988).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA] OF 1391-1607.
PubMed=6209134 [NCBI, ExPASy, EBI, Israel, Japan]
Barlow D.P.,
Green N.M.,
Kurkinen M.,
Hogan B.L.M.;
"Sequencing of laminin B chain cDNAs reveals C-terminal regions of coiled-coil alpha-helix.";
EMBO J. 3:2355-2362(1984).
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[5]
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X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 771-932.
DOI=10.1006/jmbi.1996.0191; PubMed=8648630 [NCBI, ExPASy, EBI, Israel, Japan]
Stetefeld J.,
Mayer U.,
Timpl R.,
Huber R.;
"Crystal structure of three consecutive laminin-type epidermal growth factor-like (LE) modules of laminin gamma1 chain harboring the nidogen binding site.";
J. Mol. Biol. 257:644-657(1996).
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[6]
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STRUCTURE BY NMR OF 824-881.
DOI=10.1006/jmbi.1996.0192; PubMed=8648631 [NCBI, ExPASy, EBI, Israel, Japan]
Baumgartner R.,
Czisch M.,
Mayer U.,
Poeschl E.,
Huber R.,
Timpl R.,
Holak T.A.;
"Structure of the nidogen binding LE module of the laminin gamma1 chain in solution.";
J. Mol. Biol. 257:658-668(1996).
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- FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
- SUBUNIT: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-1 is a subunit of laminin-1 (EHS laminin), laminin-2 (merosin), laminin-3 (S-laminin), laminin-4 (S-merosin), laminin-6 (K-laminin) and laminin-7 (KS-laminin).
- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.
- TISSUE SPECIFICITY: Found in the basement membranes (major component).
- DOMAIN: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
- DOMAIN: Domains VI and IV are globular.
- SIMILARITY: Contains 11 laminin EGF-like domains.
- SIMILARITY: Contains 1 laminin IV type A domain.
- SIMILARITY: Contains 1 laminin N-terminal domain.
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