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UniProtKB/Swiss-Prot entry P02062


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HBB_HORSE
Primary accession number P02062
Secondary accession numbers None
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on July 21, 1986 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 76)
Name and origin of the protein
Protein name Hemoglobin subunit beta
Synonyms Hemoglobin beta chain
Beta-globin
Gene name
Name: HBB
From
Equus caballus (Horse) [TaxID: 9796] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
Protein existence 1: Evidence at protein level;
References
[1]
PROTEIN SEQUENCE.
PubMed=7409745 [NCBI, ExPASy, EBI, Israel, Japan]
Matsuda G., Maita T., Braunitzer G., Schrank B.;
"Hemoglobins, XXXIII. Note on the sequence of the hemoglobins of the horse.";
Hoppe-Seyler's Z. Physiol. Chem. 361:1107-1116(1980).
[2]
PROTEIN SEQUENCE OF 1-82 AND 117-146.
PubMed=4876811 [NCBI, ExPASy, EBI, Israel, Japan]
Smith D.B.;
"Amino acid sequences of some tryptic peptides from the beta-chain of horse hemoglobin.";
Can. J. Biochem. 46:825-843(1968).
[3]
DETERMINATION OF AMIDES, AND PROTEIN SEQUENCE OF 52-54.
PubMed=5529282 [NCBI, ExPASy, EBI, Israel, Japan]
Smith D.B., Chung W.P.;
"Amide groups of some tryptic peptides from the beta-chain of horse hemoglobin.";
Can. J. Biochem. 48:1160-1164(1970).
[4]
X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
PubMed=5659617 [NCBI, ExPASy, EBI, Israel, Japan]
Perutz M.F., Miurhead H., Cox J.M., Goaman L.C., Mathews F.S., McGandy E.L., Webb L.E.;
"Three-dimensional Fourier synthesis of horse oxyhaemoglobin at 2.8-A resolution: (1) X-ray analysis.";
Nature 219:29-32(1968).
[5]
X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
PubMed=5659637 [NCBI, ExPASy, EBI, Israel, Japan]
Perutz M.F., Muirhead H., Cox J.M., Goaman L.C.;
"Three-dimensional Fourier synthesis of horse oxyhaemoglobin at 2.8 A resolution: the atomic model.";
Nature 219:131-139(1968).
[6]
X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
DOI=10.1016/0022-2836(77)90256-X; PubMed=561852 [NCBI, ExPASy, EBI, Israel, Japan]
Ladner R.C., Heidner E.J., Perutz M.F.;
"The structure of horse methaemoglobin at 2.0-A resolution.";
J. Mol. Biol. 114:385-414(1977).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
PIR B91688; HBHO.
RefSeq XP_001504239.1; -.
3D structure databases
PDB
1G0B; X-ray; 1.90 A; B=1-146.[ExPASy / RCSB / EBI]
1IBE; X-ray; 1.80 A; B=1-146.[ExPASy / RCSB / EBI]
1IWH; X-ray; 1.55 A; B=1-146.[ExPASy / RCSB / EBI]
1NS6; X-ray; 2.05 A; B=1-146.[ExPASy / RCSB / EBI]
1NS9; X-ray; 1.60 A; B=1-146.[ExPASy / RCSB / EBI]
1S0H; X-ray; 3.00 A; B=1-146.[ExPASy / RCSB / EBI]
1Y8H; X-ray; 3.10 A; B/D=1-146.[ExPASy / RCSB / EBI]
1Y8I; X-ray; 2.60 A; B/D=1-146.[ExPASy / RCSB / EBI]
1Y8K; X-ray; 2.30 A; B/D=1-146.[ExPASy / RCSB / EBI]
2D5X; X-ray; 1.45 A; B=1-146.[ExPASy / RCSB / EBI]
2DHB; X-ray; 2.80 A; B=1-146.[ExPASy / RCSB / EBI]
2MHB; X-ray; 2.00 A; B=1-146.[ExPASy / RCSB / EBI]
2ZLT; X-ray; 1.90 A; B=1-146.[ExPASy / RCSB / EBI]
2ZLU; X-ray; 2.00 A; B=1-146.[ExPASy / RCSB / EBI]
2ZLV; X-ray; 2.00 A; B=1-146.[ExPASy / RCSB / EBI]
2ZLW; X-ray; 2.90 A; B/D=1-146.[ExPASy / RCSB / EBI]
2ZLX; X-ray; 2.80 A; B/D=1-146.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1G0B; -.
1IBE; -.
1IWH; -.
1NS6; -.
1NS9; -.
1S0H; -.
1Y8H; -.
1Y8I; -.
1Y8K; -.
2D5X; -.
2DHB; -.
2MHB; -.
2ZLT; -.
2ZLU; -.
2ZLV; -.
2ZLW; -.
2ZLX; -.
ModBase P02062.
Ontologies
GO
GO:0005344; Molecular function: oxygen transporter activity (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR012292; Globin.
IPR000971; Globin_subset.
IPR002337; Haemoglobin_b.
Graphical view of domain structure.
Gene3D G3DSA:1.10.490.10; Globin_related; 1.
PANTHER PTHR11442:SF7; Beta_haem; 1.
Pfam PF00042; Globin; 1.
Pfam graphical view of domain structure.
PRINTS PR00814; BETAHAEM.
PROSITE PS01033; GLOBIN; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P02062.
ProtoNet P02062.
Genome annotation databases
GeneID 100054109; -.
Phylogenomic databases
HOVERGEN P02062; -.
Other
LinkHub P02062; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport; Transport.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   146  146     Hemoglobin subunit beta. PRO_0000052975
METAL   63    63        Iron (heme distal ligand). 
METAL   92    92        Iron (heme proximal ligand). 
HELIX   5    15  11      
HELIX   20    34  15      
HELIX   36    45  10      
HELIX   51    56  6      
HELIX   58    75  18      
HELIX   76    80  5      
HELIX   81    94  14      
HELIX   101   118  18      
HELIX   119   121  3      
HELIX   124   141  18      
HELIX   143   145  3      
Sequence information
Length: 146 AA [This is the length of the unprocessed precursor] Molecular weight: 16008 Da [This is the MW of the unprocessed precursor] CRC64: 734664793DA642EE [This is a checksum on the sequence]
        10         20         30         40         50         60 
VQLSGEEKAA VLALWDKVNE EEVGGEALGR LLVVYPWTQR FFDSFGDLSN PGAVMGNPKV 

        70         80         90        100        110        120 
KAHGKKVLHS FGEGVHHLDN LKGTFAALSE LHCDKLHVDP ENFRLLGNVL VVVLARHFGK 

       130        140 
DFTPELQASY QKVVAGVANA LAHKYH 

P02062 in FASTA format

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