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UniProtKB/Swiss-Prot entry Q04826


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name 1B40_HUMAN
Primary accession number Q04826
Secondary accession numbers O19556 O19651 P01890 P30477 P30478 Q29762 Q29842 Q29855 Q30173 Q31603 Q9TPT6
Integrated into Swiss-Prot on October 1, 1993
Sequence was last modified on October 1, 1993 (Sequence version 1)
Annotations were last modified on    June 10, 2008 (Entry version 75)
Name and origin of the protein
Protein name HLA class I histocompatibility antigen, B-40 alpha chain [Precursor]
Synonyms MHC class I antigen B*40
Bw-60
Gene name
Name: HLA-B
Synonyms: HLAB
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE (ALLELE B*4001).
DOI=10.1007/BF00404425; PubMed=2437025 [NCBI, ExPASy, EBI, Israel, Japan]
Ways J.W., Lawlor D.A., Wan A.M., Parham P.;
"A transposable epitope of HLA-B7, B40 molecules.";
Immunogenetics 25:323-328(1987).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*4001).
PubMed=7517584 [NCBI, ExPASy, EBI, Israel, Japan]
Little A.-M., Domena J.D., Hildebrand W.H., Shen S.Y., Barber L.D., Marsh S.G.E., Bias W.B., Parham P.;
"HLA-B67: a member of the HLA-B16 family that expresses the ME1 epitope.";
Tissue Antigens 43:38-43(1994).
[3]
PROTEIN SEQUENCE OF 25-295 (B*4001).
DOI=10.1021/bi00285a036; PubMed=6193808 [NCBI, ExPASy, EBI, Israel, Japan]
Lopez de Castro J.A., Bragado R., Strong D.M., Strominger J.L.;
"Primary structure of papain-solubilized human histocompatibility antigen HLA-B40 (-Bw60). An outline of alloantigenic determinants.";
Biochemistry 22:3961-3969(1983).
[4]
NUCLEOTIDE SEQUENCE (ALLELE B*4002).
PubMed=1362296 [NCBI, ExPASy, EBI, Israel, Japan]
Domena J.D., Johnston-Dow L., Parham P.;
"The B*4002 allele encodes the B61 antigen: B40* is identical to B61.";
Tissue Antigens 40:254-256(1992).
[5]
NUCLEOTIDE SEQUENCE OF 13-318 (ALLELE B*4002).
TISSUE=Blood;
PubMed=1481202 [NCBI, ExPASy, EBI, Israel, Japan]
Lin L., Watanabe Y., Tokunaga K., Kuwata S., Kohsaka T., Akaza T.;
"A common Japanese haplotype HLA-A26-Cw3-B61-DR9-DQ3 carries HLA-B*4002.";
Tissue Antigens 40:257-260(1992).
[6]
NUCLEOTIDE SEQUENCE (ALLELES B*4003 AND B*4004).
DOI=10.1038/357326a0; PubMed=1317015 [NCBI, ExPASy, EBI, Israel, Japan]
Belich M.P., Madrigal J.A., Hildebrand W.H., Zemmour J., Williams R.C., Luz R., Petzl-Erler M.L., Parham P.;
"Unusual HLA-B alleles in two tribes of Brazilian Indians.";
Nature 357:326-329(1992).
[7]
NUCLEOTIDE SEQUENCE (ALLELE B*4005).
PubMed=1385528 [NCBI, ExPASy, EBI, Israel, Japan]
Hildebrand W.H., Madrigal J.A., Belich M.P., Zemmour J., Ward F.E., Williams R.C., Parham P.;
"Serologic cross-reactivities poorly reflect allelic relationships in the HLA-B12 and HLA-B21 groups. Dominant epitopes of the alpha 2 helix.";
J. Immunol. 149:3563-3568(1992).
[8]
NUCLEOTIDE SEQUENCE (ALLELE B*4006).
Herrero M.J.;
Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE (ALLELE B*4006).
TISSUE=Blood;
DOI=10.1034/j.1399-0039.2003.610103.x; PubMed=12622774 [NCBI, ExPASy, EBI, Israel, Japan]
Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., Madrigal J.A., Little A.-M.;
"Cloning and sequencing full-length HLA-B and -C genes.";
Tissue Antigens 61:20-48(2003).
[10]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*4008).
PubMed=8525480 [NCBI, ExPASy, EBI, Israel, Japan]
Adams E.J., Little A.-M., Arnett K.L., Leushner J., Parham P.;
"Identification of a novel HLA-B40 allele (B*4008) in a patient with leukemia.";
Tissue Antigens 46:204-205(1995).
[11]
NUCLEOTIDE SEQUENCE [MRNA] OF 26-206 (ALLELE B*4009).
DOI=10.1034/j.1399-0039.1999.530504.x; PubMed=10372543 [NCBI, ExPASy, EBI, Israel, Japan]
Marcos C.Y., Fernandez-Vina M.A., Lazaro A.M., Moraes M.E., Moraes J.R., Stastny P.;
"Novel HLA-A and HLA-B alleles in South American Indians.";
Tissue Antigens 53:476-485(1999).
[12]
NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*4016).
DOI=10.1034/j.1399-0039.2000.560401.x; PubMed=11098929 [NCBI, ExPASy, EBI, Israel, Japan]
Ellis J.M., Mack S.J., Leke R.F.G., Quakyi I., Johnson A.H., Hurley C.K.;
"Diversity is demonstrated in class I HLA-A and HLA-B alleles in Cameroon, Africa: description of HLA-A*03012, *2612, *3006 and HLA-B*1403, *4016, *4703.";
Tissue Antigens 56:291-302(2000).
[13]
NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*4027).
Pimtanothai N., Hurley C.K.;
"Novel HLA-B allele.";
Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U03698; AAA03719.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L41628; AAA65040.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L09736; AAA36224.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D14343; BAA03277.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M84383; AAA59633.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M84384; AAA59634.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M84694; AAA03661.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X84725; CAA59215.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ300180; CAC15501.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ292253; CAC29021.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L41353; AAC41923.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L76934; AAA96270.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF017023; AAB70252.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF017022; AAB70252.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF181472; AAD56943.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF181471; AAD56943.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR I38437; HLHU40.
I56149; I56149.
I59655; I59655.
I61905; I61905.
I61906; I61906.
S52486; S52486.
UniGene Hs.654404
3D structure databases
HSSP P30474; 1A9E. [HSSP ENTRY / PDB]
SMR Q04826; 25-300.
ModBase Q04826.
Enzyme and pathway databases
Reactome REACT_6900; Signaling in Immune System.
Organism-specific databases
HGNC HGNC:4932; HLA-B.
GeneLynx HLA-B; Homo sapiens.
GenAtlas HLA-B.
MIM 142830; gene. [NCBI / EBI]
PharmGKB PA35056; -.
GeneCards Q04826.
Gene expression databases
CleanEx HS_HLA-B; -.
Family and domain databases
InterPro IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003006; Ig/MHC_CS.
IPR003597; Ig_C1-set.
IPR011161; MHC_I-like_Ag-recog.
IPR001039; MHC_I_a_a1/a2.
IPR010579; MHC_I_a_C.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.10; Ig-like_fold; 1.
G3DSA:3.30.500.10; MHC_I-like_Ag-recog; 1.
Pfam PF07654; C1-set; 1.
PF00129; MHC_I; 1.
PF06623; MHC_I_C; 1.
Pfam graphical view of domain structure.
PRINTS PR01638; MHCCLASSI.
ProDom PD000050; MHC_I; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00407; IGc1; 1.
SMART graphical view of domain structure.
PROSITE PS50835; IG_LIKE; 1.
PS00290; IG_MHC; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q04826.
Genome annotation databases
Ensembl ENSG00000206450; Homo sapiens. [Contig view]
Phylogenomic databases
HOVERGEN Q04826; -.
Other
SOURCE HLA-B; Homo sapiens.
ProtoNet Q04826.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Glycoprotein; Host-virus interaction; Immune response; Membrane; MHC I; Polymorphism; Signal; Transmembrane; Ubl conjugation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    24  24      
CHAIN   25   362  338     HLA class I histocompatibility antigen, B-40 alpha chain. PRO_0000018844
TOPO_DOM   25   308  284     Extracellular (Potential). 
TRANSMEM   309   332  24     Potential. 
TOPO_DOM   333   362  30     Cytoplasmic (Potential). 
DOMAIN   209   295  87     Ig-like C1-type. 
REGION   25   114  90     Alpha-1. 
REGION   115   206  92     Alpha-2. 
REGION   207   298  92     Alpha-3. 
REGION   299   308  10     Connecting peptide. 
CARBOHYD   110   110        N-linked (GlcNAc...). 
DISULFID   125   188         
DISULFID   227   283         
VARIANT   9     9  1     L -> V (in allele B*4001). VAR_016435 
VARIANT   14    15  2     WG -> SA (in allele B*4001). VAR_016436
VARIANT   17    17  1     V -> L (in allele B*4001). VAR_016437 
VARIANT   35    36  2     SV -> AM (in allele B*4001 and allele B*4016). VAR_016438
VARIANT   87    87  1     E -> N (in allele B*4008; requires 2 nucleotide substitutions). VAR_016439 [3D]
VARIANT   91    91  1     S -> F (in allele B*4008). VAR_016440 [3D]
VARIANT   118   119  2     TL -> II (in allele B*4003). VAR_016441
VARIANT   119   119  1     L -> W (in allele B*4006). VAR_016442 [3D]
VARIANT   121   121  1     S -> R (in allele B*4001 and allele B*4003). VAR_016443 [3D]
VARIANT   121   121  1     S -> T (in allele B*4006). VAR_016444 [3D]
VARIANT   127   127  1     V -> L (in allele B*4003). VAR_016445 [3D]
VARIANT   137   137  1     H -> Y (in allele B*4009). VAR_016658 [3D]
VARIANT   138   138  1     N -> D (in allele B*4004 and allele B*4009). VAR_016446 [3D]
VARIANT   140   140  1     Y -> N (in allele B*4027). VAR_016447 [3D]
VARIANT   140   140  1     Y -> S (in allele B*4004). VAR_016448 [3D]
VARIANT   167   167  1     T -> S (in allele B*4001). VAR_016449 [3D]
VARIANT   171   171  1     W -> L (in allele B*4001). VAR_016450 [3D]
VARIANT   176   176  1     V -> E (in allele B*4005 and allele B*4016). VAR_016451 [3D]
VARIANT   180   180  1     L -> R (in allele B*4016). VAR_016655 [3D]
VARIANT   187   187  1     E -> L (in allele B*4005; requires 2 nucleotide substitutions). VAR_016452 [3D]
VARIANT   201   202  2     ET -> DK (in allele B*4001 and allele B*4016). VAR_016453
VARIANT   204   204  1     Q -> E (in allele B*4001 and allele B*4016). VAR_016454 [3D]
CONFLICT   167   167        Missing (in Ref. 3; AA sequence). 
Sequence information
Length: 362 AA [This is the length of the unprocessed precursor] Molecular weight: 40505 Da [This is the MW of the unprocessed precursor] CRC64: 7D66503ACD865152 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MRVTAPRTLL LLLWGAVALT ETWAGSHSMR YFHTSVSRPG RGEPRFITVG YVDDTLFVRF 

        70         80         90        100        110        120 
DSDATSPRKE PRAPWIEQEG PEYWDRETQI SKTNTQTYRE SLRNLRGYYN QSEAGSHTLQ 

       130        140        150        160        170        180 
SMYGCDVGPD GRLLRGHNQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAARVAEQL 

       190        200        210        220        230        240 
RAYLEGECVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT 

       250        260        270        280        290        300 
WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 

       310        320        330        340        350        360 
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL 


TA 

Q04826 in FASTA format

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