[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1016/0092-8674(84)90348-9; PubMed=6421489 [NCBI, ExPASy, EBI, Israel, Japan] Flanagan J.G., Lefranc M.-P., Rabbitts T.H.; "Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences."; Cell 36:681-688(1984).
[2]	PROTEIN SEQUENCE (BUT). PubMed=416441 [NCBI, ExPASy, EBI, Israel, Japan] Torano A., Putnam F.W.; "Complete amino acid sequence of the alpha 2 heavy chain of a human IgA2 immunoglobulin of the A2m (2) allotype."; Proc. Natl. Acad. Sci. U.S.A. 75:966-969(1978).
[3]	PROTEIN SEQUENCE (MYELOMA PROTEIN LAN). PubMed=286295 [NCBI, ExPASy, EBI, Israel, Japan] Tsuzukida Y., Wang C.-C., Putnam F.W.; "Structure of the A2m(1) allotype of human IgA -- a recombinant molecule."; Proc. Natl. Acad. Sci. U.S.A. 76:1104-1108(1979).
[4]	REVIEW. PubMed=2241915 [NCBI, ExPASy, EBI, Israel, Japan] Kerr M.A.; "The structure and function of human IgA."; Biochem. J. 271:285-296(1990).
[5]	GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-205, AND MASS SPECTROMETRY. TISSUE=Bile; DOI=10.1074/mcp.M400015-MCP200; PubMed=15084671 [NCBI, ExPASy, EBI, Israel, Japan] Kristiansen T.Z., Bunkenborg J., Gronborg M., Molina H., Thuluvath P.J., Argani P., Goggins M.G., Maitra A., Pandey A.; "A proteomic analysis of human bile."; Mol. Cell. Proteomics 3:715-728(2004).
[6]	GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-131 AND ASN-205, AND MASS SPECTROMETRY. TISSUE=Plasma; DOI=10.1002/pmic.200300556; PubMed=14760718 [NCBI, ExPASy, EBI, Israel, Japan] Bunkenborg J., Pilch B.J., Podtelejnikov A.V., Wisniewski J.R.; "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."; Proteomics 4:454-465(2004).
[7]	GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-205 AND ASN-327, AND MASS SPECTROMETRY. TISSUE=Saliva; DOI=10.1021/pr050492k; PubMed=16740002 [NCBI, ExPASy, EBI, Israel, Japan] Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.; "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."; J. Proteome Res. 5:1493-1503(2006).
[8]	GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-131, AND MASS SPECTROMETRY. TISSUE=Plasma; DOI=10.1021/pr0604559; PubMed=17330941 [NCBI, ExPASy, EBI, Israel, Japan] Bernhard O.K., Kapp E.A., Simpson R.J.; "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."; J. Proteome Res. 6:987-995(2007).

Comments

FUNCTION: Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.
SUBUNIT: Monomeric or polymeric.
INTERACTION:
O14519:CDK2AP1; NbExp=1; IntAct=EBI-1044357, EBI-1052532;
O60285:NUAK1; NbExp=1; IntAct=EBI-1044357, EBI-1046789;
O94921:PFTK1; NbExp=1; IntAct=EBI-1044357, EBI-1043945;
MISCELLANEOUS: The sequence of the A2m(1) allotype is shown.
SIMILARITY: Contains 3 Ig-like (immunoglobulin-like) domains.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

J00221; AAB59396.1; ALT_INIT; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

B22360; B22360.

UniGene

Hs.648398

3D structure databases

HSSP

P01876; 1OW0. [HSSP ENTRY / PDB]

SMR

P01877; 110-318.

ModBase

P01877.

Protein-protein interaction databases

IntAct

P01877; -.

Protein family/group databases

IMGT

J00221.

Organism-specific databases

HGNC:5479; IGHA2.

HPA001217; -.
HPA006013; -.

MIM

147000; gene. [NCBI / EBI]

PharmGKB

PA29711; -.

GeneCards

P01877.

Gene expression databases

ArrayExpress

P01877; -.

GermOnline

ENSG00000177199; Homo sapiens.

Ontologies

GO:0005624;	Cellular component: membrane fraction (non-traceable author statement from UniProtKB).
GO:0003823;	Molecular function: antigen binding (traceable author statement from UniProtKB).
GO:0005515;	Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0006955;	Biological process: immune response (non-traceable author statement from UniProtKB).
QuickGo view.

Family and domain databases

InterPro

IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003006; Ig/MHC_CS.
IPR003597; Ig_C1-set.
Graphical view of domain structure.

Gene3D

G3DSA:2.60.40.10; Ig-like_fold; 3.

Pfam

PF07654; C1-set; 2.
Pfam graphical view of domain structure.

SMART

SM00407; IGc1; 2.
SMART graphical view of domain structure.

PROSITE

PS50835; IG_LIKE; 3.
PS00290; IG_MHC; 2.
PROSITE graphical view of domain structure (profiles).

BLOCKS

P01877.

Genome annotation databases

Ensembl

ENSG00000211890; Homo sapiens. [Contig view]

Phylogenomic databases

HOVERGEN

P01877; -.

Other

DrugBank

DB00028; Immune globulin.

IGHA2; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; Glycoprotein; Immunoglobulin C region; Immunoglobulin domain; Repeat.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`<1 340`	`>340`	`Ig alpha-2 chain C region.`	`PRO_0000153567`
`DOMAIN`	`6 98`	`93`	`Ig-like 1.`
`DOMAIN`	`112 207`	`96`	`Ig-like 2.`
`DOMAIN`	`215 317`	`103`	`Ig-like 3.`
`CARBOHYD`	`47 47`		`N-linked (GlcNAc...).`
`CARBOHYD`	`92 92`		`N-linked (GlcNAc...).`
`CARBOHYD`	`131 131`		`N-linked (GlcNAc...).`
`CARBOHYD`	`205 205`		`N-linked (GlcNAc...).`
`CARBOHYD`	`327 327`		`N-linked (GlcNAc...).`
`DISULFID`	`26 85`		`Probable.`
`DISULFID`	`101 101`		`Interchain (with light chain) (Probable).`
`DISULFID`	`109 109`		`Interchain (with heavy chain) (Probable).`
`DISULFID`	`110 167`		`Probable.`
`DISULFID`	`134 191`		`Probable.`
`DISULFID`	`169 169`		`Interchain (with heavy chain) (Probable).`
`DISULFID`	`179 179`		`Interchain (with heavy chain of another subunit) (Potential).`
`DISULFID`	`237 300`		`Probable.`
`DISULFID`	`339 339`		`Interchain (with J chain) (Probable).`
`VARIANT`	`93 93`	`1`	`P -> S (in A2M(2) allotype).`	`VAR_003879`
`VARIANT`	`102 102`	`1`	`P -> R (in A2M(2) allotype).`	`VAR_003880`
`VARIANT`	`279 279`	`1`	`F -> Y (in A2M(2) allotype).`	`VAR_003881`
`VARIANT`	`296 296`	`1`	`D -> E (in A2M(2) allotype).`	`VAR_003882`
`VARIANT`	`326 326`	`1`	`V -> I (in A2M(2) allotype).`	`VAR_003883`
`VARIANT`	`335 335`	`1`	`V -> A (in A2M(2) allotype).`	`VAR_003884`
`NON_TER`	`1 1`

Sequence information

Length: 340 AA [This is the length of the unprocessed precursor]

Molecular weight: 36508 Da [This is the MW of the unprocessed precursor]

CRC64: 98922700756F3276 [This is a checksum on the sequence]

        10         20         30         40         50         60 
ASPTSPKVFP LSLDSTPQDG NVVVACLVQG FFPQEPLSVT WSESGQNVTA RNFPPSQDAS 

        70         80         90        100        110        120 
GDLYTTSSQL TLPATQCPDG KSVTCHVKHY TNPSQDVTVP CPVPPPPPCC HPRLSLHRPA 

       130        140        150        160        170        180 
LEDLLLGSEA NLTCTLTGLR DASGATFTWT PSSGKSAVQG PPERDLCGCY SVSSVLPGCA 

       190        200        210        220        230        240 
QPWNHGETFT CTAAHPELKT PLTANITKSG NTFRPEVHLL PPPSEELALN ELVTLTCLAR 

       250        260        270        280        290        300 
GFSPKDVLVR WLQGSQELPR EKYLTWASRQ EPSQGTTTFA VTSILRVAAE DWKKGDTFSC 

       310        320        330        340 
MVGHEALPLA FTQKTIDRLA GKPTHVNVSV VMAEVDGTCY

P01877 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools