[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1016/0161-5890(89)90133-8; PubMed=2497341 [NCBI, ExPASy, EBI, Israel, Japan] Rinfret A., Horne C., Dorrington K.J., Klein M.; "Cloning, sequencing and expression of the rearranged MOPC 315 VH gene segment."; Mol. Immunol. 26:431-434(1989).
[2]	PROTEIN SEQUENCE OF 1-31. DOI=10.1073/pnas.74.12.5692; PubMed=414225 [NCBI, ExPASy, EBI, Israel, Japan] Jilka R.L., Pestka S.; "Amino acid sequence of the precursor region of MOPC-315 mouse immunoglobulin heavy chain."; Proc. Natl. Acad. Sci. U.S.A. 74:5692-5696(1977).
[3]	PROTEIN SEQUENCE OF 1-21. PubMed=428562 [NCBI, ExPASy, EBI, Israel, Japan] Schechter I., Wolf O., Zemell R., Burstein Y.; "Structure and function of immunoglobulin genes and precursors."; Fed. Proc. 38:1839-1845(1979).
[4]	PROTEIN SEQUENCE OF 19-136. DOI=10.1073/pnas.71.4.1123; PubMed=4524622 [NCBI, ExPASy, EBI, Israel, Japan] Francis S.H., Leslie R.G.Q., Hood L., Eisen H.N.; "Amino-acid sequence of the variable region of the heavy (alpha) chain of a mouse myeloma protein with anti-hapten activity."; Proc. Natl. Acad. Sci. U.S.A. 71:1123-1127(1974).
[5]	SEQUENCE REVISION TO 53. PubMed=268248 [NCBI, ExPASy, EBI, Israel, Japan] Padlan E.A., Davies D.R., Pecht I., Givol D., Wright C.; "Model-building studies of antigen-binding sites: the hapten-binding site of mopc-315."; Cold Spring Harb. Symp. Quant. Biol. 41:627-637(1977).

Comments

MISCELLANEOUS: This alpha chain was isolated from a myeloma protein that has anti-dinitrophenyl activity.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M27638; AAA61337.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X07880; CAA30727.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00457481; -.

PIR

PL0102; AVMS35.

3D structure databases

HSSP

P01820; 1G7J. [HSSP ENTRY / PDB]

SMR

P01822; 20-137.

ModBase

P01822.

Protein family/group databases

IMGT

M27638.
X07880.

Ontologies

GO:0003823;	Molecular function: antigen binding (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013106; Ig_V-set.
IPR003596; Ig_V-set_sub.
Graphical view of domain structure.

Gene3D

G3DSA:2.60.40.10; Ig-like_fold; 1.

Pfam

PF07686; V-set; 1.
Pfam graphical view of domain structure.

SMART

SM00406; IGv; 1.
SMART graphical view of domain structure.

PROSITE

PS50835; IG_LIKE; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

Ensembl

ENSMUSG00000076672; Mus musculus. [Contig view]

Phylogenomic databases

HOVERGEN

P01822; -.

Other

ProtoNet

P01822.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; Disulfide bond; Immunoglobulin domain; Immunoglobulin V region; Signal.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 18`	`18`
`CHAIN`	`19 137`	`119`	`Ig heavy chain V region MOPC 315.`	`PRO_0000015232`
`REGION`	`19 48`	`30`	`Framework-1.`
`REGION`	`49 54`	`6`	`Complementarity-determining-1.`
`REGION`	`55 68`	`14`	`Framework-2.`
`REGION`	`69 84`	`16`	`Complementarity-determining-2.`
`REGION`	`85 116`	`32`	`Framework-3.`
`REGION`	`117 126`	`10`	`Complementarity-determining-3.`
`REGION`	`127 137`	`11`	`Framework-4.`
`DISULFID`	`40 114`		`By similarity.`
`CONFLICT`	`15 15`		`G -> GG (in Ref. 1; CAA30727).`
`CONFLICT`	`15 15`		`G -> H (in Ref. 2; AA sequence).`
`CONFLICT`	`77 78`		`GY -> YG (in Ref. 4; AA sequence).`
`CONFLICT`	`102 102`		`N -> D (in Ref. 4; AA sequence).`
`CONFLICT`	`123 123`		`Missing (in Ref. 4; AA sequence).`
`NON_TER`	`137 137`

Sequence information

Length: 137 AA [This is the length of the unprocessed precursor]

Molecular weight: 15399 Da [This is the MW of the unprocessed precursor]

CRC64: FB3828304C2B81DC [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKVLSLLYLL TAIPGIMSDV QLQESGPGLV KPSQSLSLTC SVTGYSITSG YFWNWIRQFP 

        70         80         90        100        110        120 
GNKLEWLGFI KYDGSNGYNP SLKNRVSITR DTSENQFFLK LNSVTTEDTA TYYCAGDNDH 

       130 
LYYFDYWGQG TTLTVSS

P01822 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools