[1]
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NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/S0092-8674(85)80105-7; PubMed=2990730 [NCBI, ExPASy, EBI, Israel, Japan]
Maddon P.J.,
Littman D.R.,
Godfrey M.,
Maddon D.E.,
Chess L.,
Axel R.;
"The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family.";
Cell 42:93-104(1985).
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[2]
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SEQUENCE REVISION TO 26.
DOI=10.1016/0092-8674(88)90211-5; PubMed=3263213 [NCBI, ExPASy, EBI, Israel, Japan]
Littman D.R.,
Maddon P.J.,
Axel R.;
"Corrected CD4 sequence.";
Cell 55:541-541(1988).
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[3]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8723724 [NCBI, ExPASy, EBI, Israel, Japan]
Ansari-Lari M.A.,
Muzny D.M.,
Lu J.,
Lu F.,
Lilley C.E.,
Spanos S.,
Malley T.,
Gibbs R.A.;
"A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13.";
Genome Res. 6:314-326(1996).
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[4]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Brain;
PubMed=9074930 [NCBI, ExPASy, EBI, Israel, Japan]
Ansari-Lari M.A.,
Shen Y.,
Muzny D.M.,
Lee W.,
Gibbs R.A.;
"Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.";
Genome Res. 7:268-280(1997).
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[5]
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NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT TRP-265.
DOI=10.1016/0198-8859(91)90077-M; PubMed=1708753 [NCBI, ExPASy, EBI, Israel, Japan]
Hodge T.W.,
Sasso D.R.,
McDougal J.S.;
"Humans with OKT4-epitope deficiency have a single nucleotide base change in the CD4 gene, resulting in substitution of TRP240 for ARG240.";
Hum. Immunol. 30:99-104(1991).
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[6]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N.,
Chen X.,
Rolfs A.,
Halleck A.,
Hines L.,
Eisenstein S.,
Koundinya M.,
Raphael J.,
Moreira D.,
Kelley T.,
LaBaer J.,
Lin Y.,
Phelan M.,
Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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[7]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS GLU-191; SER-227 AND TRP-265.
NIEHS SNPs program;
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
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[8]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Pancreas;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[9]
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NUCLEOTIDE SEQUENCE [MRNA] OF 28-424.
TISSUE=Blood;
DOI=10.1002/eji.1830221132; PubMed=1425921 [NCBI, ExPASy, EBI, Israel, Japan]
Fomsgaard A.,
Hirsch V.M.,
Johnson P.R.;
"Cloning and sequences of primate CD4 molecules: diversity of the cellular receptor for simian immunodeficiency virus/human immunodeficiency virus.";
Eur. J. Immunol. 22:2973-2981(1992).
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[10]
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PROTEIN SEQUENCE OF 26-394, AND DISULFIDE BOND.
PubMed=2592374 [NCBI, ExPASy, EBI, Israel, Japan]
Carr S.A.,
Hemling M.E.,
Folena-Wasserman G.,
Sweet R.W.,
Anumula K.,
Barr J.R.,
Huddleston M.J.,
Taylor P.;
"Protein and carbohydrate structural analysis of a recombinant soluble CD4 receptor by mass spectrometry.";
J. Biol. Chem. 264:21286-21295(1989).
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[11]
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PROTEIN SEQUENCE OF 26-40.
DOI=10.1110/ps.04682504; PubMed=15340161 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Z.,
Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
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[12]
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INTERACTION WITH HIV-1 ENVELOPE POLYPROTEIN GP160.
PubMed=2214026 [NCBI, ExPASy, EBI, Israel, Japan]
Crise B.,
Buonocore L.,
Rose J.K.;
"CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor.";
J. Virol. 64:5585-5593(1990).
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[13]
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PALMITOYLATION AT CYS-419 AND CYS-422.
PubMed=1618861 [NCBI, ExPASy, EBI, Israel, Japan]
Crise B.,
Rose J.K.;
"Identification of palmitoylation sites on CD4, the human immunodeficiency virus receptor.";
J. Biol. Chem. 267:13593-13597(1992).
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[14]
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REMOVAL FROM CELL SURFACE BY HIV-1 NEF, AND MUTAGENESIS OF MET-432; SER-433; 438-LEU-LEU-439 AND SER-440.
DOI=10.1016/0092-8674(94)90360-3; PubMed=8124721 [NCBI, ExPASy, EBI, Israel, Japan]
Aiken C.,
Konner J.,
Landau N.R.,
Lenburg M.E.,
Trono D.;
"Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain.";
Cell 76:853-864(1994).
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[15]
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INTERACTION WITH HUMAN HERPESVIRUS 7 CAPSID PROTEINS.
DOI=10.1073/pnas.91.9.3872; PubMed=7909607 [NCBI, ExPASy, EBI, Israel, Japan]
Lusso P.,
Secchiero P.,
Crowley R.W.,
Garzino-Demo A.,
Berneman Z.N.,
Gallo R.C.;
"CD4 is a critical component of the receptor for human herpesvirus 7: interference with human immunodeficiency virus.";
Proc. Natl. Acad. Sci. U.S.A. 91:3872-3876(1994).
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[16]
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INTERACTION WITH SPG21, AND MUTAGENESIS OF 457-PRO-ILE-458.
DOI=10.1074/jbc.M009270200; PubMed=11113139 [NCBI, ExPASy, EBI, Israel, Japan]
Zeitlmann L.,
Sirim P.,
Kremmer E.,
Kolanus W.;
"Cloning of ACP33 as a novel intracellular ligand of CD4.";
J. Biol. Chem. 276:9123-9132(2001).
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[17]
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SUBCELLULAR LOCATION.
PubMed=12517957 [NCBI, ExPASy, EBI, Israel, Japan]
Fragoso R.,
Ren D.,
Zhang X.,
Su M.W.,
Burakoff S.J.,
Jin Y.J.;
"Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling.";
J. Immunol. 170:913-921(2003).
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[18]
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INTERACTION WITH HIV-1 SURFACE PROTEIN GP120.
DOI=10.1021/bi051120s; PubMed=16331979 [NCBI, ExPASy, EBI, Israel, Japan]
Sharma D.,
Balamurali M.M.,
Chakraborty K.,
Kumaran S.,
Jeganathan S.,
Rashid U.,
Ingallinella P.,
Varadarajan R.;
"Protein minimization of the gp120 binding region of human CD4.";
Biochemistry 44:16192-16202(2005).
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[19]
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GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-296, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1021/pr8008012; PubMed=19159218 [NCBI, ExPASy, EBI, Israel, Japan]
Chen R.,
Jiang X.,
Sun D.,
Han G.,
Wang F.,
Ye M.,
Wang L.,
Zou H.;
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.";
J. Proteome Res. 8:651-661(2009).
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[20]
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X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 26-208.
DOI=10.1038/348411a0; PubMed=1701030 [NCBI, ExPASy, EBI, Israel, Japan]
Wang J.,
Yan Y.,
Garrett T.P.,
Liu J.,
Rodgers D.W.,
Garlick R.L.,
Tarr G.E.,
Husain Y.,
Reinherz E.L.,
Harrison S.C.;
"Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains.";
Nature 348:411-418(1990).
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[21]
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X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 26-208.
DOI=10.1038/348419a0; PubMed=2247146 [NCBI, ExPASy, EBI, Israel, Japan]
Ryu S.-E.,
Kwong P.D.,
Truneh A.,
Porter T.G.,
Arthos J.,
Rosenberg M.,
Dai X.,
Xuong N.-H.,
Axel R.,
Sweet R.W.,
Hendrickson W.A.;
"Crystal structure of an HIV-binding recombinant fragment of human CD4.";
Nature 348:419-426(1990).
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[22]
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X-RAY CRYSTALLOGRAPHY (3.9 ANGSTROMS) OF 26-388.
DOI=10.1038/387527a0; PubMed=9168119 [NCBI, ExPASy, EBI, Israel, Japan]
Wu H.,
Kwong P.D.,
Hendrickson W.A.;
"Dimeric association and segmental variability in the structure of human CD4.";
Nature 387:527-530(1997).
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[23]
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X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 26-208 IN COMPLEX WITH HIV SURFACE PROTEIN GP120.
DOI=10.1038/31405; PubMed=9641677 [NCBI, ExPASy, EBI, Israel, Japan]
Kwong P.D.,
Wyatt R.,
Robinson J.,
Sweet R.W.,
Sodroski J.,
Hendrickson W.A.;
"Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody.";
Nature 393:648-659(1998).
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