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UniProtKB/Swiss-Prot entry P01583


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IL1A_HUMAN
Primary accession number P01583
Secondary accession number Q7RU02
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on July 21, 1986 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 107)
Name and origin of the protein
Protein name Interleukin-1 alpha [Precursor]
Synonyms IL-1 alpha
Hematopoietin-1
Gene name
Name: IL1A
Synonyms: IL1F1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1038/315641a0; PubMed=2989698 [NCBI, ExPASy, EBI, Israel, Japan]
March C.J., Mosley B., Larsen A., Cerretti D.P., Braedt G., Price V., Gillis S., Henney C.S., Kronheim S.R., Grabstein K., Conlon P.J., Hopp T.P., Cosman D.;
"Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs.";
Nature 315:641-647(1985).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1093/nar/14.8.3167; PubMed=3486405 [NCBI, ExPASy, EBI, Israel, Japan]
Furutani Y., Notake M., Fukui T., Ohue M., Nomura H., Yamada M., Nakamura S.;
"Complete nucleotide sequence of the gene for human interleukin 1 alpha.";
Nucleic Acids Res. 14:3167-3179(1986).
[3]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT SER-114.
DOI=10.1093/nar/13.16.5869; PubMed=2994016 [NCBI, ExPASy, EBI, Israel, Japan]
Furutani Y., Notake M., Yamayoshi M., Yamagishi J., Nomura H., Ohue M., Furuta R., Fukui T., Yamada M., Nakamura S.;
"Cloning and characterization of the cDNAs for human and rabbit interleukin-1 precursor.";
Nucleic Acids Res. 13:5869-5882(1985).
[4]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT SER-114.
PubMed=2635664 [NCBI, ExPASy, EBI, Israel, Japan]
Kotenko S.V., Bulenkov M.T., Veiko V.P., Epishin S.M., Lomakin I.B., Emel'Yanov A.V., Kozlov A.P., Konusova V.G., Kotov A.Y., Kurbatova T.V., Reshetnikov V.L., Simbirtsev A.S., Ketlinskii S.A., Vinetskii Y.P.;
"Cloning of the cDNA coding for human prointerleukin-1 alpha and prointerleukin-1 beta.";
Dokl. Akad. Nauk SSSR 309:1005-1008(1989).
[5]
NUCLEOTIDE SEQUENCE.
PubMed=3485152 [NCBI, ExPASy, EBI, Israel, Japan]
Gubler U., Chua A.O., Stern A.S., Hellmann C.P., Vitek M.P., Dechiara T.M., Benjamin W.R., Collier K.J., Dukovich M., Familletti P.C., Fiedler-Nagy C., Jenson J., Kaffka K., Kilian P.L., Stremlo D., Wittreich B.H., Woehle D., Mizel S.B., Lomedico P.T.;
"Recombinant human interleukin 1 alpha: purification and biological characterization.";
J. Immunol. 136:2492-2497(1986).
[6]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3493774 [NCBI, ExPASy, EBI, Israel, Japan]
Nishida T., Nishino N., Takano M., Kawai K., Bando K., Masui Y., Nakai S., Hirai Y.;
"cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line.";
Biochem. Biophys. Res. Commun. 143:345-352(1987).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1006/geno.2002.6751; PubMed=11991722 [NCBI, ExPASy, EBI, Israel, Japan]
Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G., Kornman K.;
"A sequence-based map of the nine genes of the human interleukin-1 cluster.";
Genomics 79:718-725(2002).
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[10]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS GLN-85; SER-114 AND ASN-138.
SeattleSNPs program for genomic applications;
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
[11]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[12]
PROTEIN SEQUENCE OF 113-132.
PubMed=3281727 [NCBI, ExPASy, EBI, Israel, Japan]
Zsebo K.M., Wypych J., Yuschenkoff V.N., Lu H., Hunt P., Dukes P.P., Langley K.E.;
"Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow.";
Blood 71:962-968(1988).
[13]
MYRISTOYLATION AT LYS-82 AND LYS-83.
PubMed=8346241 [NCBI, ExPASy, EBI, Israel, Japan]
Stevenson F.T., Bursten S.L., Fanton C., Locksley R.M., Lovett D.H.;
"The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece.";
Proc. Natl. Acad. Sci. U.S.A. 90:7245-7249(1993).
[14]
X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
DOI=10.1021/bi00463a009; PubMed=2346741 [NCBI, ExPASy, EBI, Israel, Japan]
Graves B.J., Hatada M.H., Hendrickson W.A., Miller J.K., Madison V.S., Satow Y.;
"Structure of interleukin 1 alpha at 2.7-A resolution.";
Biochemistry 29:2679-2684(1990).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X02531; CAA26371.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X03833; CAA27448.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X02851; CAA26604.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X56086; CAA39566.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M28983; AAA59134.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M15329; AAA59133.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BN000002; CAD29871.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT007014; AAP35660.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR457414; CAG33695.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF536338; AAM96189.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC013142; AAH13142.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A23385; ICHU1A.
RefSeq NP_000566.3; -.
UniGene Hs.1722
3D structure databases
PDB
1ITA; Model; -; A=121-271.[ExPASy / RCSB / EBI]
2ILA; X-ray; 2.30 A; A=117-271.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1ITA; -.
2ILA; -.
ModBase P01583.
Protein-protein interaction databases
IntAct P01583; -.
PTM databases
PhosphoSite P01583; -.
Organism-specific databases
H-InvDB HIX0002385; -.
HGNC HGNC:5991; IL1A.
GenAtlas IL1A.
HPA CAB004449; -.
MIM 147760; gene. [NCBI / EBI]
PharmGKB PA29807; -.
GeneCards P01583.
Gene expression databases
ArrayExpress P01583; -.
CleanEx HS_IL1A; -.
GermOnline ENSG00000115008; Homo sapiens.
Ontologies
GO
GO:0005615; Cellular component: extracellular space (traceable author statement from ProtInc).
GO:0005125; Molecular function: cytokine activity (traceable author statement from ProtInc).
GO:0004871; Molecular function: signal transducer activity (traceable author statement from ProtInc).
GO:0006916; Biological process: anti-apoptosis (traceable author statement from ProtInc).
GO:0006954; Biological process: inflammatory response (traceable author statement from ProtInc).
GO:0008285; Biological process: negative regulation of cell proliferation (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR003502; IL1_propep.
IPR000975; Interleukin_1.
IPR003295; InterleukinIL1A.
IPR003294; InterleukinIL1AB.
Graphical view of domain structure.
PANTHER PTHR11420; InterleukinIL1A; 1.
Pfam PF00340; IL1; 1.
PF02394; IL1_propep; 1.
Pfam graphical view of domain structure.
PRINTS PR00264; INTERLEUKIN1.
PR01358; INTRLEUKIN1A.
PR01357; INTRLEUKN1AB.
ProDom PD002536; Interleukin_1; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00125; IL1; 1.
SMART graphical view of domain structure.
PROSITE PS00253; INTERLEUKIN_1; 1.
BLOCKS P01583.
ProtoNet P01583.
Genome annotation databases
Ensembl ENSG00000115008; Homo sapiens. [Contig view]
GeneID 3552; -.
KEGG hsa:3552; -.
Phylogenomic databases
HOGENOM P01583; -.
HOVERGEN P01583; -.
Other
LinkHub P01583; -.
NextBio 13868; -.
SOURCE IL1A; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Cytokine; Direct protein sequencing; Glycoprotein; Inflammatory response; Lipoprotein; Mitogen; Myristate; Polymorphism; Pyrogen; Secreted.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
PROPEP   1   112  112      PRO_0000015265
CHAIN   113   271  159     Interleukin-1 alpha. PRO_0000015266
LIPID   82    82        N6-myristoyl lysine. 
LIPID   83    83        N6-myristoyl lysine. 
CARBOHYD   102   102        N-linked (GlcNAc...) (Potential). 
CARBOHYD   141   141        N-linked (GlcNAc...) (Potential). 
VARIANT   85    85  1     R -> Q (in dbSNP:rs3783531 [NCBI]). VAR_014304 
VARIANT   114   114  1     A -> S (in dbSNP:rs17561 [NCBI]). VAR_014305 
VARIANT   125   125  1     N -> D (in dbSNP:rs17562 [NCBI]). VAR_014600 
VARIANT   138   138  1     D -> N (in dbSNP:rs3783581 [NCBI]). VAR_014306 
VARIANT   176   176  1     D -> H (in dbSNP:rs1801715 [NCBI]). VAR_014601 
STRAND   124   138  15      
STRAND   143   146  4      
STRAND   152   155  4      
TURN   161   162  2      
STRAND   166   172  7      
STRAND   181   186  6      
STRAND   191   194  4      
STRAND   203   206  4      
HELIX   216   221  6      
STRAND   222   228  7      
TURN   229   230  2      
STRAND   231   236  6      
TURN   240   241  2      
TURN   258   259  2      
STRAND   264   267  4      
Sequence information
Length: 271 AA [This is the length of the unprocessed precursor] Molecular weight: 30607 Da [This is the MW of the unprocessed precursor] CRC64: CBCCC49569D9ED40 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAKVPDMFED LKNCYSENEE DSSSIDHLSL NQKSFYHVSY GPLHEGCMDQ SVSLSISETS 

        70         80         90        100        110        120 
KTSKLTFKES MVVVATNGKV LKKRRLSLSQ SITDDDLEAI ANDSEEEIIK PRSAPFSFLS 

       130        140        150        160        170        180 
NVKYNFMRII KYEFILNDAL NQSIIRANDQ YLTAAALHNL DEAVKFDMGA YKSSKDDAKI 

       190        200        210        220        230        240 
TVILRISKTQ LYVTAQDEDQ PVLLKEMPEI PKTITGSETN LLFFWETHGT KNYFTSVAHP 

       250        260        270 
NLFIATKQDY WVCLAGGPPS ITDFQILENQ A 

P01583 in FASTA format

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