[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
DOI=10.1038/287411a0; PubMed=6159538 [NCBI, ExPASy, EBI, Israel, Japan]
Goeddel D.V.,
Yelverton E.,
Ullrich A.,
Heyneker H.L.,
Miozzari G.,
Holmes W.,
Seeburg P.H.,
Dull T.J.,
May L.,
Stebbing N.,
Crea R.,
Maeda S.,
McCandliss R.,
Sloma A.,
Tabor J.M.,
Gross M.,
Familletti P.C.,
Pestka S.;
"Human leukocyte interferon produced by E. coli is biologically active.";
Nature 287:411-416(1980).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
DOI=10.1038/290020a0; PubMed=6163083 [NCBI, ExPASy, EBI, Israel, Japan]
Goeddel D.V.,
Leung D.W.,
Dull T.J.,
Gross M.,
Lawn R.M.,
McCandliss R.,
Seeburg P.H.,
Ullrich A.,
Yelverton E.,
Gray P.W.;
"The structure of eight distinct cloned human leukocyte interferon cDNAs.";
Nature 290:20-26(1981).
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[3]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
PubMed=6170983 [NCBI, ExPASy, EBI, Israel, Japan]
Lawn R.M.,
Gross M.,
Houck C.M.,
Franke A.E.,
Gray P.V.,
Goeddel D.V.;
"DNA sequence of a major human leukocyte interferon gene.";
Proc. Natl. Acad. Sci. U.S.A. 78:5435-5439(1981).
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[4]
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NUCLEOTIDE SEQUENCE.
TISSUE=Bone marrow tumor;
PubMed=3906813 [NCBI, ExPASy, EBI, Israel, Japan]
Oliver G.,
Balbas P.,
Valle F.,
Soberon X.,
Bolivar F.;
"Cloning of human leukocyte interferon cDNA and a strategy for its production in E. coli.";
Rev. Latinoam. Microbiol. 27:141-150(1985).
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[5]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Placenta;
PubMed=9694076 [NCBI, ExPASy, EBI, Israel, Japan]
Austruy E.,
Bagnis C.,
Carbuccia N.,
Maroc C.,
Birg F.,
Dubreuil P.,
Mannoni P.,
Chabannon C.;
"A defective retroviral vector encoding human interferon alpha 2 can transduce human leukemic cell lines.";
Cancer Gene Ther. 5:247-256(1998).
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[6]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 7-188.
PubMed=6158094 [NCBI, ExPASy, EBI, Israel, Japan]
Streuli M.,
Nagata S.,
Weissmann C.;
"At least three human type alpha interferons: structure of alpha 2.";
Science 209:1343-1347(1980).
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[7]
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NUCLEOTIDE SEQUENCE OF 24-188.
DOI=10.1093/nar/11.16.5661; PubMed=6310510 [NCBI, ExPASy, EBI, Israel, Japan]
Weber H.,
Weissmann C.;
"Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli.";
Nucleic Acids Res. 11:5661-5669(1983).
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[8]
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PROTEIN SEQUENCE OF 24-112 AND 136-188.
DOI=10.1038/287408a0; PubMed=6159537 [NCBI, ExPASy, EBI, Israel, Japan]
Allen G.,
Fantes K.H.;
"A family of structural genes for human lymphoblastoid (leukocyte-type) interferon.";
Nature 287:408-411(1980).
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[9]
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PROTEIN SEQUENCE OF 24-58.
PubMed=9425112 [NCBI, ExPASy, EBI, Israel, Japan]
Nyman T.A.,
Toeloe H.,
Parkkinen J.,
Kalkkinen N.;
"Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes.";
Biochem. J. 329:295-302(1998).
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[10]
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DISULFIDE BONDS.
DOI=10.1038/289606a0; PubMed=6162107 [NCBI, ExPASy, EBI, Israel, Japan]
Wetzel R.;
"Assignment of the disulphide bonds of leukocyte interferon.";
Nature 289:606-607(1981).
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[11]
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GLYCOSYLATION AT THR-129, AND VARIANTS ALPHA-2B AND ALPHA-2C.
PubMed=2049076 [NCBI, ExPASy, EBI, Israel, Japan]
Adolf G.R.,
Kalsner I.,
Ahorn H.,
Maurer-Fogy I.,
Cantell K.;
"Natural human interferon-alpha 2 is O-glycosylated.";
Biochem. J. 276:511-518(1991).
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[12]
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POLYMORPHISM.
PubMed=7627809 [NCBI, ExPASy, EBI, Israel, Japan]
Lee N.,
Ni D.,
Brissette R.,
Chou M.,
Hussain M.,
Gill D.S.,
Liao M.-J.,
Testa D.;
"Interferon-alpha 2 variants in the human genome.";
J. Interferon Cytokine Res. 15:341-349(1995).
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[13]
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3D-STRUCTURE MODELING.
DOI=10.1002/prot.340170109; PubMed=8234245 [NCBI, ExPASy, EBI, Israel, Japan]
Murgolo N.J.,
Windsor W.T.,
Hruza A.,
Reichert P.,
Tsarbopoulos A.,
Baldwin S.,
Huang E.,
Pramanik B.,
Ealick S.,
Trotta P.P.;
"A homology model of human interferon alpha-2.";
Proteins 17:62-74(1993).
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[14]
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X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
DOI=10.1016/S0969-2126(96)00152-9; PubMed=8994971 [NCBI, ExPASy, EBI, Israel, Japan]
Radhakrishnan R.,
Walter L.J.,
Hruza A.,
Reichert P.,
Trotta P.P.,
Nagabhushan T.L.,
Walter M.R.;
"Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography.";
Structure 4:1453-1463(1996).
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[15]
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STRUCTURE BY NMR.
DOI=10.1006/jmbi.1997.1396; PubMed=9417943 [NCBI, ExPASy, EBI, Israel, Japan]
Klaus W.,
Gsell B.,
Labhardt A.M.,
Wipf B.,
Senn H.;
"The three-dimensional high resolution structure of human interferon alpha-2a determined by heteronuclear NMR spectroscopy in solution.";
J. Mol. Biol. 274:661-675(1997).
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[16]
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VARIANT [LARGE SCALE ANALYSIS] LEU-177.
DOI=10.1126/science.1133427; PubMed=16959974 [NCBI, ExPASy, EBI, Israel, Japan]
Sjoeblom T.,
Jones S.,
Wood L.D.,
Parsons D.W.,
Lin J.,
Barber T.D.,
Mandelker D.,
Leary R.J.,
Ptak J.,
Silliman N.,
Szabo S.,
Buckhaults P.,
Farrell C.,
Meeh P.,
Markowitz S.D.,
Willis J.,
Dawson D.,
Willson J.K.V.,
Gazdar A.F., ![]()
Hartigan J.,
Wu L.,
Liu C.,
Parmigiani G.,
Park B.H.,
Bachman K.E.,
Papadopoulos N.,
Vogelstein B.,
Kinzler K.W.,
Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal cancers.";
Science 314:268-274(2006).
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