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UniProtKB/Swiss-Prot entry P01562


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IFNA1_HUMAN
Primary accession number P01562
Secondary accession numbers Q14605 Q2M1L8 Q52LB8 Q5VYQ2 Q7M4Q1 Q8WZ68 Q9UMJ3
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on July 21, 1986 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 95)
Name and origin of the protein
Protein name Interferon alpha-1/13 [Precursor]
Synonyms Interferon alpha-D
LeIF D
Gene names
Name: IFNA1
and
Name: IFNA13
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0378-1119(80)90137-7; PubMed=6157600 [NCBI, ExPASy, EBI, Israel, Japan]
Mantei N., Schwarzstein M., Streuli M., Panem S., Nagata S., Weissmann C.;
"The nucleotide sequence of a cloned human leukocyte interferon cDNA.";
Gene 10:1-10(1980).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1038/285547a0; PubMed=6157095 [NCBI, ExPASy, EBI, Israel, Japan]
Taniguchi T., Mantei N., Schwarzstein M., Nagata S., Muramatsu M., Weissmann C.;
"Human leukocyte and fibroblast interferons are structurally related.";
Nature 285:547-549(1980).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1038/290020a0; PubMed=6163083 [NCBI, ExPASy, EBI, Israel, Japan]
Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M., McCandliss R., Seeburg P.H., Ullrich A., Yelverton E., Gray P.W.;
"The structure of eight distinct cloned human leukocyte interferon cDNAs.";
Nature 290:20-26(1981).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=6479148 [NCBI, ExPASy, EBI, Israel, Japan]
Todokoro K., Kioussis D., Weissmann C.;
"Two non-allelic human interferon alpha genes with identical coding regions.";
EMBO J. 3:1809-1812(1984).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0022-2836(85)90401-2; PubMed=4057246 [NCBI, ExPASy, EBI, Israel, Japan]
Henco K., Brosius J., Fujisawa A., Fujisawa J., Haynes J.R., Hochstadt J., Kovacic T., Pasek M., Schamboeck A., Schmid J., Todokoro K., Waelchli M., Nagata S., Weissmann C.;
"Structural relationship of human interferon alpha genes and pseudogenes.";
J. Mol. Biol. 185:227-260(1985).
[6]
NUCLEOTIDE SEQUENCE.
PubMed=2985969 [NCBI, ExPASy, EBI, Israel, Japan]
Capon D.J., Shepard H.M., Goeddel D.V.;
"Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides.";
Mol. Cell. Biol. 5:768-779(1985).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ALA-10.
Rostoks N.;
Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ALA-10; VAL-137 AND GLY-163.
Livingston R.J., Rieder M.J., Shaffer T., Bertucci C., Baier C.N., Rajkumar N., Willa H.T., Daniels M., Downing T.K., Stanaway I.B., Nguyen C.P., Gildersleeve H., Cassidy C.M., Johnson E.J., Swanson J.E., McFarland I., Yool B., Park C., Nickerson D.A.;
"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu).";
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02465; PubMed=15164053 [NCBI, ExPASy, EBI, Israel, Japan]
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.;
"DNA sequence and analysis of human chromosome 9.";
Nature 429:369-374(2004).
[10]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-10.
TISSUE=Cerebellum;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[11]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-189.
DOI=10.1093/nar/11.16.5661; PubMed=6310510 [NCBI, ExPASy, EBI, Israel, Japan]
Weber H., Weissmann C.;
"Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli.";
Nucleic Acids Res. 11:5661-5669(1983).
[12]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-189.
TISSUE=Leukocyte;
Chen H.H., Yu X.B.;
Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
[13]
PROTEIN SEQUENCE OF 24-59, AND FUNCTION.
PubMed=1634550 [NCBI, ExPASy, EBI, Israel, Japan]
Zoon K.C., Miller D., Bekisz J., zur Nedden D., Enterline J.C., Nguyen N.Y., Hu R.-Q.;
"Purification and characterization of multiple components of human lymphoblastoid interferon-alpha.";
J. Biol. Chem. 267:15210-15216(1992).
[14]
PROTEIN SEQUENCE OF 24-58.
PubMed=9425112 [NCBI, ExPASy, EBI, Israel, Japan]
Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.;
"Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes.";
Biochem. J. 329:295-302(1998).
[15]
POLYMORPHISM.
DOI=10.1089/10799900050151021; PubMed=11032395 [NCBI, ExPASy, EBI, Israel, Japan]
Hussain M., Ni D., Gill D., Liao M.-J.;
"IFN-alpha-1a gene is the major variant in the North American population.";
J. Interferon Cytokine Res. 20:763-768(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
V00537; CAA23798.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
J00210; AAB59403.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
V00538; CAA23799.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X00803; CAA25381.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X75934; CAA53538.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
DQ185447; ABA03167.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL353732; CAH72904.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL353732; CAH72911.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC069427; AAH69427.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC074928; AAH74928.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC074929; AAH74929.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC093988; AAH93988.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC112002; AAI12003.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC112300; AAI12301.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC112302; AAI12303.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M29884; AAA52714.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF439447; AAL35223.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR C23285; IVHUA1.
F42753; F42753.
H42753; H42753.
RefSeq NP_008831.3; -.
NP_076918.1; -.
UniGene Hs.37026
3D structure databases
HSSP P01563; 1ITF. [HSSP ENTRY / PDB]
SMR P01562; 24-189.
ModBase P01562.
Protein-protein interaction databases
DIP DIP:6020N; -.
Polymorphism databases
NIEHS-SNPs IFNA1.
Organism-specific databases
H-InvDB HIX0034868; -.
HGNC HGNC:5417; IFNA1.
HGNC:5419; IFNA13.
GenAtlas IFNA1.
MIM 147578; gene. [NCBI / EBI]
147660; gene. [NCBI / EBI]
PharmGKB PA29656; -.
GeneCards P01562.
Gene expression databases
CleanEx HS_IFNA1; -.
HS_IFNA13; -.
GermOnline ENSG00000197919; Homo sapiens.
Ontologies
GO
GO:0005132; Molecular function: interferon-alpha/beta receptor binding (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR012351; 4_helix_cytokine_core.
IPR015589; IFNa.
IPR000471; Interferon_abd.
Graphical view of domain structure.
Gene3D G3DSA:1.20.1250.10; 4_helix_cytokine_core; 1.
PANTHER PTHR11691:SF9; IFNa; 1.
PTHR11691; Interferon_abd; 1.
Pfam PF00143; Interferon; 1.
Pfam graphical view of domain structure.
PRINTS PR00266; INTERFERONAB.
ProDom PD000550; Interferon_abd; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00076; IFabd; 1.
SMART graphical view of domain structure.
PROSITE PS00252; INTERFERON_A_B_D; 1.
BLOCKS P01562.
ProtoNet P01562.
Genome annotation databases
Ensembl ENSG00000197919; Homo sapiens. [Contig view]
GeneID 3439; -.
3447; -.
KEGG hsa:3439; -.
Phylogenomic databases
HOGENOM P01562; -.
HOVERGEN P01562; -.
Other
NextBio 13552; -.
SOURCE IFNA1; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Antiviral defense; Cytokine; Direct protein sequencing; Polymorphism; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    23  23      
CHAIN   24   189  166     Interferon alpha-1/13. PRO_0000016359
DISULFID   24   122        By similarity. 
DISULFID   52   162        By similarity. 
VARIANT   10    10  1     V -> A (in dbSNP:rs1758567 [NCBI]). VAR_024508 
VARIANT   137   137  1     A -> V (in alpha-1B; dbSNP:rs2230050 [NCBI]). VAR_013000 
VARIANT   163   163  1     A -> G. VAR_025173 
CONFLICT   116   116        L -> P (in Ref. 12; AAL35223). 
CONFLICT   172   172        M -> V (in Ref. 12; AAL35223). 
Sequence information
Length: 189 AA [This is the length of the unprocessed precursor] Molecular weight: 21725 Da [This is the MW of the unprocessed precursor] CRC64: F32F9CB969606B69 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MASPFALLMV LVVLSCKSSC SLGCDLPETH SLDNRRTLML LAQMSRISPS SCLMDRHDFG 

        70         80         90        100        110        120 
FPQEEFDGNQ FQKAPAISVL HELIQQIFNL FTTKDSSAAW DEDLLDKFCT ELYQQLNDLE 

       130        140        150        160        170        180 
ACVMQEERVG ETPLMNADSI LAVKKYFRRI TLYLTEKKYS PCAWEVVRAE IMRSLSLSTN 


LQERLRRKE 

P01562 in FASTA format

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