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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
PubMed=6205394 [NCBI, ExPASy, EBI, Israel, Japan]
Gubler U.,
Chua A.O.,
Hoffman B.J.,
Collier K.J.,
Eng J.;
"Cloned cDNA to cholecystokinin mRNA predicts an identical preprocholecystokinin in pig brain and gut.";
Proc. Natl. Acad. Sci. U.S.A. 81:4307-4310(1984).
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[2]
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PROTEIN SEQUENCE OF 70-102.
Mutt V.,
Jorpes J.E.;
Submitted (AUG-1970) to the PIR data bank.
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[3]
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PROTEIN SEQUENCE OF 91-102.
DOI=10.1021/ja00704a033; PubMed=5410106 [NCBI, ExPASy, EBI, Israel, Japan]
Ondetti M.A.,
Pluscec J.,
Sabo E.F.,
Sheehan J.T.,
Williams N.;
"Synthesis of cholecystokinin-pancreozymin. I. The C-terminal dodecapeptide.";
J. Am. Chem. Soc. 92:195-199(1970).
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[4]
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SULFATION.
PubMed=8443599 [NCBI, ExPASy, EBI, Israel, Japan]
Rosenquist G.L.,
Nicholas H.B.;
"Analysis of sequence requirements for protein tyrosine sulfation.";
Protein Sci. 2:215-222(1993).
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- FUNCTION: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
- SUBUNIT: Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain (By similarity).
- SUBCELLULAR LOCATION: Secreted.
- TISSUE SPECIFICITY: Synthesized in both cerebral cortex and duodenal mucosa.
- PTM: The precursor is cleaved by proteases to produce a number of active cholecystokinins. Brain contains CCK-octapeptide (CCK8) and several CCK-desoctapeptides; whereas pig gut contains intact CCK33, CCK39, and CCK58 as well as CCK-octapeptide and the CCK-desoctapeptides. Distribution differences are due to tissue-specific post-translational processing events.
- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 114 AA [This is the length of the unprocessed precursor] |
Molecular weight: 12526 Da [This is the MW of the unprocessed precursor] |
CRC64: 8F8C05DF29B0E6EE [This is a checksum on the sequence] |
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10 20 30 40 50 60
MNGGLCLCVL MAVLAAGTLA QPVPPADSAV PGAQEEEAHR RQLRAVQKVD GESRAHLGAL
70 80 90 100 110
LARYIQQARK APSGRVSMIK NLQSLDPSHR ISDRDYMGWM DFGRRSAEEY EYTS
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P01356 in FASTA format |
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