ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P01354


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name GAST_FELCA
Primary accession number P01354
Secondary accession numbers None
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on November 1, 1991 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 61)
Name and origin of the protein
Protein name Gastrin [Precursor]
Synonyms None
Contains Big gastrin
     (Gastrin-34)
     (G34)
Gastrin
Gene name
Name: GAST
Synonyms: GAS
From
Felis silvestris catus (Cat) [TaxID: 9685] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1773057 [NCBI, ExPASy, EBI, Israel, Japan]
Kim S.J., Uhm K.N., Kang Y.K., Yoo O.J.;
"Bovine and feline gastrin cDNA sequences and the amino acid and nucleotide sequence homologies among mammalian species.";
DNA Seq. 1:181-187(1991).
[2]
PROTEIN SEQUENCE OF 76-92.
DOI=10.1021/ja01039a051; PubMed=5784957 [NCBI, ExPASy, EBI, Israel, Japan]
Agarwal K.L., Kenner G.W., Sheppard R.C.;
"Feline gastrin. An example of peptide sequence analysis by mass spectrometry.";
J. Am. Chem. Soc. 91:3096-3097(1969).
Comments
  • FUNCTION: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
  • SUBCELLULAR LOCATION: Secreted.
  • SIMILARITY: Belongs to the gastrin/cholecystokinin family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X16582; CAA34599.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S14401; GMCT.
3D structure databases
ModBase P01354.
Family and domain databases
InterPro IPR001651; Gastrin.
IPR013152; Gastrin_CCK_CS.
Graphical view of domain structure.
Pfam PF00918; Gastrin; 1.
Pfam graphical view of domain structure.
SMART SM00029; GASTRIN; 1.
SMART graphical view of domain structure.
PROSITE PS00259; GASTRIN; 1.
BLOCKS P01354.
ProtoNet P01354.
Phylogenomic databases
HOVERGEN P01354; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amidation; Cleavage on pair of basic residues; Direct protein sequencing; Hormone; Phosphoprotein; Pyrrolidone carboxylic acid; Secreted; Signal; Sulfation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom  To Length Description FTId
SIGNAL   1    21  21      
PROPEP   22    58  37      PRO_0000010625
PEPTIDE   59    92  34     Big gastrin. PRO_0000010626
PEPTIDE   76    92  17     Gastrin. PRO_0000010627
PROPEP   96   104  9      PRO_0000010628
MOD_RES   59    59        Pyrrolidone carboxylic acid. 
MOD_RES   76    76        Pyrrolidone carboxylic acid. 
MOD_RES   87    87        Sulfotyrosine. 
MOD_RES   92    92        Phenylalanine amide. 
MOD_RES   96    96        Phosphoserine (By similarity). 
Sequence information
Length: 104 AA [This is the length of the unprocessed precursor] Molecular weight: 11482 Da [This is the MW of the unprocessed precursor] CRC64: 4DB92E4416A7AC9F [This is a checksum on the sequence]
        10         20         30         40         50         60 
MQRLCVCVLI LALALTAFSE ASWKPRSQLQ DAPSGPGANG GLEPHWLNRL GPASHHRWQL 

        70         80         90        100 
GLQGPPQQVA DLSKKQGPWL EEEEAAYGWM DFGRRSAEDG DQHP 

P01354 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!