[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Gastric mucosa; PubMed=2262079 [NCBI, ExPASy, EBI, Israel, Japan] Gantz I., Takeuchi T., Yamada T.; "Cloning of canine gastrin cDNA's encoding variant amino acid sequences."; Digestion 46:99-104(1990).
[2]	PROTEIN SEQUENCE OF 59-92. TISSUE=Gastric mucosa; DOI=10.1016/0196-9781(86)90045-8; PubMed=3763441 [NCBI, ExPASy, EBI, Israel, Japan] Bonato C., Eng J., Hulmes J.D., Miedel M., Pan Y.-C.E., Yalow R.S.; "Sequences of gastrins purified from a single antrum of dog and of goat."; Peptides 7:689-693(1986).
[3]	PROTEIN SEQUENCE OF 76-92, AND PHOSPHORYLATION. DOI=10.1007/BF01899905; PubMed=5799207 [NCBI, ExPASy, EBI, Israel, Japan] Agarwal K.L., Kenner G.W., Sheppard R.C.; "Structure and synthesis of canine gastrin."; Experientia 25:346-348(1969).
[4]	PROTEIN SEQUENCE OF 96-104. TISSUE=Gastric mucosa; DOI=10.1016/0167-0115(89)90264-4; PubMed=2756156 [NCBI, ExPASy, EBI, Israel, Japan] Desmond H., Varro A., Young J., Gregory H., Nemeth J., Dockray G.J.; "The constitution and properties of phosphorylated and unphosphorylated C-terminal fragments of progastrin from dog and ferret antrum."; Regul. Pept. 25:223-233(1989).

Comments

FUNCTION: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the gastrin/cholecystokinin family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases
PIR	B61053; GMDG.
3D structure databases
ModBase	P01353.
Family and domain databases
InterPro	IPR001651; Gastrin. IPR013152; Gastrin_CCK_CS. Graphical view of domain structure.
Pfam	PF00918; Gastrin; 1. Pfam graphical view of domain structure.
SMART	SM00029; GASTRIN; 1. SMART graphical view of domain structure.
PROSITE	PS00259; GASTRIN; 1.
BLOCKS	P01353.
ProtoNet	P01353.
Genome annotation databases
Ensembl	ENSCAFG00000015924; Canis familiaris. [Contig view]
Phylogenomic databases
HOVERGEN	P01353; -.
Other
UniRef	View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amidation; Cleavage on pair of basic residues; Direct protein sequencing; Hormone; Phosphoprotein; Pyrrolidone carboxylic acid; Secreted; Signal; Sulfation.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 21`	`21`	`Potential.`
`PROPEP`	`22 58`	`37`		`PRO_0000010613`
`PEPTIDE`	`59 92`	`34`	`Big gastrin.`	`PRO_0000010614`
`PEPTIDE`	`76 92`	`17`	`Gastrin.`	`PRO_0000010615`
`PROPEP`	`96 104`	`9`		`PRO_0000010616`
`MOD_RES`	`59 59`		`Pyrrolidone carboxylic acid.`
`MOD_RES`	`76 76`		`Pyrrolidone carboxylic acid.`
`MOD_RES`	`87 87`		`Sulfotyrosine.`
`MOD_RES`	`92 92`		`Phenylalanine amide.`
`MOD_RES`	`96 96`		`Phosphoserine.`
`VARIANT`	`85 85`	`1`	`A -> T.`
`CONFLICT`	`83 85`		`EEA -> AEE (in Ref. 3; AA sequence).`

Sequence information

Length: 104 AA [This is the length of the unprocessed precursor]

Molecular weight: 11519 Da [This is the MW of the unprocessed precursor]

CRC64: 73BF72A18DFE78CA [This is a checksum on the sequence]

        10         20         30         40         50         60 
MQRLCVYVLI LALALATFSE ASWKPRSRLQ DAPSGPGANR GLEPHGLDQL GPASHHRRQL 

        70         80         90        100 
GLQGPPQLVA DLSKKQGPWM EEEEAAYGWM DFGRRSAEEG DQRP

P01353 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools