[1]	NUCLEOTIDE SEQUENCE. TISSUE=Liver; PubMed=2608050 [NCBI, ExPASy, EBI, Israel, Japan] Lund T., Olsen J., Rehfeld J.F.; "Cloning and sequencing of the bovine gastrin gene."; Mol. Endocrinol. 3:1585-1588(1989).
[2]	NUCLEOTIDE SEQUENCE. PubMed=1773057 [NCBI, ExPASy, EBI, Israel, Japan] Kim S.J., Uhm K.N., Kang Y.K., Yoo O.J.; "Bovine and feline gastrin cDNA sequences and the amino acid and nucleotide sequence homologies among mammalian species."; DNA Seq. 1:181-187(1991).
[3]	PROTEIN SEQUENCE OF 76-92. PubMed=5665711 [NCBI, ExPASy, EBI, Israel, Japan] Agarwal K.L., Beacham J., Bentley P.H., Gregory R.A., Kenner G.W., Sheppard R.C., Tracy H.J.; "Isolation, structure and synthesis of ovine and bovine gastrins."; Nature 219:614-615(1968).

Comments

FUNCTION: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the gastrin/cholecystokinin family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M31657; AAA30537.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X16581; CAA34598.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

S14400; GMBO.

NP_776340.1; -.

3D structure databases

ModBase

P01352.

Family and domain databases

InterPro

IPR001651; Gastrin.
IPR013152; Gastrin_CCK_CS.
Graphical view of domain structure.

Pfam

PF00918; Gastrin; 1.
Pfam graphical view of domain structure.

SMART

SM00029; GASTRIN; 1.
SMART graphical view of domain structure.

PS00259; GASTRIN; 1.

Genome annotation databases

Ensembl

ENSBTAG00000017663; Bos taurus. [Contig view]

GeneID

280800; -.

KEGG

bta:280800; -.

Phylogenomic databases

HOVERGEN

P01352; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amidation; Cleavage on pair of basic residues; Direct protein sequencing; Hormone; Phosphoprotein; Pyrrolidone carboxylic acid; Secreted; Signal; Sulfation.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 21`	`21`
`PROPEP`	`22 58`	`37`		`PRO_0000010609`
`PEPTIDE`	`59 92`	`34`	`Big gastrin.`	`PRO_0000010610`
`PEPTIDE`	`76 92`	`17`	`Gastrin.`	`PRO_0000010611`
`PROPEP`	`96 104`	`9`		`PRO_0000010612`
`MOD_RES`	`59 59`		`Pyrrolidone carboxylic acid.`
`MOD_RES`	`76 76`		`Pyrrolidone carboxylic acid.`
`MOD_RES`	`87 87`		`Sulfotyrosine.`
`MOD_RES`	`92 92`		`Phenylalanine amide.`
`MOD_RES`	`96 96`		`Phosphoserine (By similarity).`
`CONFLICT`	`32 32`		`A -> L (in Ref. 1; AAA30537).`
`CONFLICT`	`37 37`		`G -> R (in Ref. 1; AAA30537).`
`CONFLICT`	`48 48`		`N -> T (in Ref. 1; AAA30537).`
`CONFLICT`	`74 74`		`K -> N (in Ref. 1; AAA30537).`
`CONFLICT`	`81 81`		`E -> G (in Ref. 1; AAA30537).`
`CONFLICT`	`96 96`		`S -> M (in Ref. 1; AAA30537).`
`CONFLICT`	`99 99`		`E -> G (in Ref. 1; AAA30537).`

Sequence information

Length: 104 AA [This is the length of the unprocessed precursor]

Molecular weight: 11573 Da [This is the MW of the unprocessed precursor]

CRC64: 54D03BF200F299F2 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MQRLCAHVLI LVLALAAFCE ASWKPHSHLQ DAPVAPGANR GQEPLRMNRL GPASNPRRQL 

        70         80         90        100 
GLQDPPHMVA DLSKKQGPWV EEEEAAYGWM DFGRRSAEEG DQHP

P01352 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools