[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. PubMed=6296142 [NCBI, ExPASy, EBI, Israel, Japan] Kwok S.C.M., Chan S.J., Steiner D.F.; "Cloning and nucleotide sequence analysis of the dog insulin gene. Coded amino acid sequence of canine preproinsulin predicts an additional C-peptide fragment."; J. Biol. Chem. 258:2357-2363(1983).
[2]	PROTEIN SEQUENCE OF 25-54 AND 90-110. DOI=10.1016/0002-9343(66)90145-8; PubMed=5949593 [NCBI, ExPASy, EBI, Israel, Japan] Smith L.F.; "Species variation in the amino acid sequence of insulin."; Am. J. Med. 40:662-666(1966).

Comments

FUNCTION: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
SUBUNIT: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the insulin family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

V00179; CAA23475.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

A92413; IPDG.

NP_001123565.1; -.

3D structure databases

HSSP

P01317; 1APH. [HSSP ENTRY / PDB]

SMR

P01321; 25-84.

ModBase

P01321.

Ontologies

GO:0005576;	Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005179;	Molecular function: hormone activity (inferred from electronic annotation from UniProtKB-KW).
GO:0006006;	Biological process: glucose metabolic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR004825; Ins/IGF/relaxin.
Graphical view of domain structure.

Gene3D

G3DSA:1.10.100.10; Ins/IGF/relaxin; 1.

Pfam

PF00049; Insulin; 1.
Pfam graphical view of domain structure.

PRINTS

PR00277; INSULINB.

ProDom

PD015667; Mollusc_ins; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00078; IlGF; 1.
SMART graphical view of domain structure.

PROSITE

PS00262; INSULIN; 1.

Genome annotation databases

Ensembl

ENSCAFG00000010092; Canis familiaris. [Contig view]

GeneID

483665; -.

KEGG

cfa:483665; -.

Phylogenomic databases

HOVERGEN

P01321; -.

OMA

P01321; PAPAFVN.

Other

ProtoNet

P01321.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Carbohydrate metabolism; Cleavage on pair of basic residues; Direct protein sequencing; Disulfide bond; Glucose metabolism; Hormone; Secreted; Signal.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 24`	`24`
`PEPTIDE`	`25 54`	`30`	`Insulin B chain.`	`PRO_0000015777`
`PROPEP`	`57 87`	`31`	`C peptide.`	`PRO_0000015778`
`PEPTIDE`	`90 110`	`21`	`Insulin A chain.`	`PRO_0000015779`
`DISULFID`	`31 96`		`Interchain (between B and A chains).`
`DISULFID`	`43 109`		`Interchain (between B and A chains).`
`DISULFID`	`95 100`

Sequence information

Length: 110 AA [This is the length of the unprocessed precursor]

Molecular weight: 12190 Da [This is the MW of the unprocessed precursor]

CRC64: A574791864A4FB98 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MALWMRLLPL LALLALWAPA PTRAFVNQHL CGSHLVEALY LVCGERGFFY TPKARREVED 

        70         80         90        100        110 
LQVRDVELAG APGEGGLQPL ALEGALQKRG IVEQCCTSIC SLYQLENYCN

P01321 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools