[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS ASP-604; ASP-653; GLN-985 DEL; TYR-1043; THR-1059; GLY-1312; ARG-1437; HIS-1463; THR-1936; GLU-2091; LEU-2149; ARG-2170 AND HIS-2242.
DOI=10.1111/j.1432-1033.1987.tb11466.x; PubMed=3595599 [NCBI, ExPASy, EBI, Israel, Japan]
Malthiery Y.,
Lissitzky S.;
"Primary structure of human thyroglobulin deduced from the sequence of its 8448-base complementary DNA.";
Eur. J. Biochem. 165:491-498(1987).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT GLY-1312.
TISSUE=Thyroid;
PubMed=9186272 [NCBI, ExPASy, EBI, Israel, Japan]
van de Graaf S.A.R.,
Pauws E.,
de Vijlder J.J.M.,
Ris-Stalpers C.;
"The revised 8307 base pair coding sequence of human thyroglobulin transiently expressed in eukaryotic cells.";
Eur. J. Endocrinol. 136:508-515(1997).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT GLU-515.
DOI=10.1038/nature04406; PubMed=16421571 [NCBI, ExPASy, EBI, Israel, Japan]
Nusbaum C.,
Mikkelsen T.S.,
Zody M.C.,
Asakawa S.,
Taudien S.,
Garber M.,
Kodira C.D.,
Schueler M.G.,
Shimizu A.,
Whittaker C.A.,
Chang J.L.,
Cuomo C.A.,
Dewar K.,
FitzGerald M.G.,
Yang X.,
Allen N.R.,
Anderson S.,
Asakawa T.,
Blechschmidt K., ![]()
Bloom T.,
Borowsky M.L.,
Butler J.,
Cook A.,
Corum B.,
DeArellano K.,
DeCaprio D.,
Dooley K.T.,
Dorris L. III,
Engels R.,
Gloeckner G.,
Hafez N.,
Hagopian D.S.,
Hall J.L.,
Ishikawa S.K.,
Jaffe D.B.,
Kamat A.,
Kudoh J.,
Lehmann R.,
Lokitsang T.,
Macdonald P.,
Major J.E.,
Matthews C.D.,
Mauceli E.,
Menzel U.,
Mihalev A.H.,
Minoshima S.,
Murayama Y.,
Naylor J.W.,
Nicol R.,
Nguyen C.,
O'Leary S.B.,
O'Neill K.,
Parker S.C.J.,
Polley A.,
Raymond C.K.,
Reichwald K.,
Rodriguez J.,
Sasaki T.,
Schilhabel M.,
Siddiqui R.,
Smith C.L.,
Sneddon T.P.,
Talamas J.A.,
Tenzin P.,
Topham K.,
Venkataraman V.,
Wen G.,
Yamazaki S.,
Young S.K.,
Zeng Q.,
Zimmer A.R.,
Rosenthal A.,
Birren B.W.,
Platzer M.,
Shimizu N.,
Lander E.S.;
"DNA sequence and analysis of human chromosome 8.";
Nature 439:331-335(2006).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA] OF 1-730, AND VARIANTS ASP-604 AND ASP-653.
DOI=10.1111/j.1432-1033.1985.tb08717.x; PubMed=3971976 [NCBI, ExPASy, EBI, Israel, Japan]
Malthiery Y.,
Lissitzky S.;
"Sequence of the 5'-end quarter of the human-thyroglobulin messenger ribonucleic acid and of its deduced amino-acid sequence.";
Eur. J. Biochem. 147:53-58(1985).
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[5]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-415; 640-737 AND 880-1000, AND VARIANT ALA-734.
DOI=10.1016/0022-2836(87)90403-7; PubMed=3681978 [NCBI, ExPASy, EBI, Israel, Japan]
Parma J.,
Christophe D.,
Pohl V.,
Vassart G.;
"Structural organization of the 5' region of the thyroglobulin gene. Evidence for intron loss and 'exonization' during evolution.";
J. Mol. Biol. 196:769-779(1987).
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[6]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25.
DOI=10.1093/nar/13.14.5127; PubMed=2991855 [NCBI, ExPASy, EBI, Israel, Japan]
Christophe D.,
Cabrer B.,
Bacolla A.,
Targovnik H.M.,
Pohl V.,
Vassart G.;
"An unusually long poly(purine)-poly(pyrimidine) sequence is located upstream from the human thyroglobulin gene.";
Nucleic Acids Res. 13:5127-5144(1985).
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[7]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1002-1566 (ISOFORM 1), AND VARIANT GLY-1312.
DOI=10.1530/eje.0.1430789; PubMed=11124863 [NCBI, ExPASy, EBI, Israel, Japan]
Moya C.M.,
Mendive F.M.,
Rivolta C.M.,
Vassart G.,
Targovnik H.M.;
"Genomic organization of the 5' region of the human thyroglobulin gene.";
Eur. J. Endocrinol. 143:789-798(2000).
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[8]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1645-2768, AND VARIANTS LEU-2149 AND ARG-2170.
PubMed=10524569 [NCBI, ExPASy, EBI, Israel, Japan]
Mendive F.M.,
Rivolta C.M.,
Vassart G.,
Targovnik H.M.;
"Genomic organization of the 3' region of the human thyroglobulin gene.";
Thyroid 9:903-912(1999).
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[9]
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NUCLEOTIDE SEQUENCE [MRNA] OF 1504-1602 (ISOFORM 2).
DOI=10.1016/0303-7207(92)90087-M; PubMed=1639210 [NCBI, ExPASy, EBI, Israel, Japan]
Targovnik H.M.,
Cochaux P.,
Corach D.,
Vassart G.;
"Identification of a minor Tg mRNA transcript in RNA from normal and goitrous thyroids.";
Mol. Cell. Endocrinol. 84:R23-R26(1992).
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[10]
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PARTIAL PROTEIN SEQUENCE.
DOI=10.1016/0014-5793(89)80513-7; PubMed=2914619 [NCBI, ExPASy, EBI, Israel, Japan]
Marriq C.,
Lejeune P.J.,
Venot N.,
Vinet L.;
"Hormone synthesis in human thyroglobulin: possible cleavage of the polypeptide chain at the tyrosine donor site.";
FEBS Lett. 242:414-418(1989).
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[11]
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PARTIAL PROTEIN SEQUENCE.
DOI=10.1111/j.1432-1033.1993.tb18414.x; PubMed=8269951 [NCBI, ExPASy, EBI, Israel, Japan]
Gentile F.,
Salvatore G.;
"Preferential sites of proteolytic cleavage of bovine, human and rat thyroglobulin. The use of limited proteolysis to detect solvent-exposed regions of the primary structure.";
Eur. J. Biochem. 218:603-621(1993).
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[12]
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PARTIAL PROTEIN SEQUENCE.
DOI=10.1006/abbi.1995.1346; PubMed=7793989 [NCBI, ExPASy, EBI, Israel, Japan]
Xiao S.,
Pollock H.G.,
Taurog A.,
Rawitch A.B.;
"Characterization of hormonogenic sites in an N-terminal, cyanogen bromide fragment of human thyroglobulin.";
Arch. Biochem. Biophys. 320:96-105(1995).
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[13]
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PARTIAL PROTEIN SEQUENCE.
DOI=10.1006/abbi.1996.0093; PubMed=8615697 [NCBI, ExPASy, EBI, Israel, Japan]
Yang S.X.,
Pollock H.G.,
Rawitch A.B.;
"Glycosylation in human thyroglobulin: location of the N-linked oligosaccharide units and comparison with bovine thyroglobulin.";
Arch. Biochem. Biophys. 327:61-70(1996).
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[14]
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PRESENCE OF A 11TH TYROGLOBULIN TYPE-1 REPEAT.
DOI=10.1111/j.1432-1033.1996.0125h.x; PubMed=8797845 [NCBI, ExPASy, EBI, Israel, Japan]
Molina F.,
Bouanani M.,
Pau B.,
Granier C.;
"Characterization of the type-1 repeat from thyroglobulin, a cysteine-rich module found in proteins from different families.";
Eur. J. Biochem. 240:125-133(1996).
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[15]
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IODINATION AT TYR-24; TYR-1310; TYR-2573; TYR-2587 AND TYR-2766.
PubMed=2760035 [NCBI, ExPASy, EBI, Israel, Japan]
Lamas L.,
Anderson P.C.,
Fox J.W.,
Dunn J.T.;
"Consensus sequences for early iodination and hormonogenesis in human thyroglobulin.";
J. Biol. Chem. 264:13541-13545(1989).
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[16]
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SULFATION.
DOI=10.1006/bbrc.1999.1173; PubMed=10448091 [NCBI, ExPASy, EBI, Israel, Japan]
Nlend M.-C.,
Cauvi D.,
Venot N.,
Chabaud O.;
"Sulfated tyrosines of thyroglobulin are involved in thyroid hormone synthesis.";
Biochem. Biophys. Res. Commun. 262:193-197(1999).
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[17]
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SULFATION AT TYR-24.
DOI=10.1016/S0006-291X(02)02425-7; PubMed=12387814 [NCBI, ExPASy, EBI, Israel, Japan]
Venot N.,
Nlend M.-C.,
Cauvi D.,
Chabaud O.;
"The hormonogenic tyrosine 5 of porcine thyroglobulin is sulfated.";
Biochem. Biophys. Res. Commun. 298:193-197(2002).
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[18]
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VARIANT GOITER HIS-870.
DOI=10.1016/0140-6736(93)90209-Y; PubMed=8094490 [NCBI, ExPASy, EBI, Israel, Japan]
Corral J.,
Martin C.,
Perez R.,
Sanchez I.,
Mories M.T.,
San Millan J.L.,
Miralles J.M.,
Gonzalez-Sarmiento R.;
"Thyroglobulin gene point mutation associated with non-endemic simple goitre.";
Lancet 341:462-464(1993).
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[19]
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VARIANTS GOITER ARG-1264 AND SER-1996, AND VARIANTS HIS-135; ASP-604; ASP-653; ALA-734; GLU-830; GLN-985 DEL; VAL-1028; TYR-1043; THR-1059; ARG-1437; HIS-1463; ASN-1838; THR-1936; TRP-1999; GLU-2091; LEU-2149; ARG-2170; HIS-2242; ARG-2501 AND GLN-2530.
DOI=10.1210/jc.84.4.1438; PubMed=10199792 [NCBI, ExPASy, EBI, Israel, Japan]
Hishinuma A.,
Takamatsu J.,
Ohyama Y.,
Yokozawa T.,
Kanno Y.,
Kuma K.,
Yoshida S.,
Matsuura N.,
Ieiri T.;
"Two novel cysteine substitutions (C1263R and C1995S) of thyroglobulin cause a defect in intracellular transport of thyroglobulin in patients with congenital goiter and the variant type of adenomatous goiter.";
J. Clin. Endocrinol. Metab. 84:1438-1444(1999).
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[20]
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VARIANTS ALA-734; VAL-1028 AND TRP-1979, AND INVOLVEMENT IN AITD3.
DOI=10.1073/pnas.2434175100; PubMed=14657345 [NCBI, ExPASy, EBI, Israel, Japan]
Ban Y.,
Greenberg D.A.,
Concepcion E.,
Skrabanek L.,
Villanueva R.,
Tomer Y.;
"Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease.";
Proc. Natl. Acad. Sci. U.S.A. 100:15119-15124(2003).
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