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UniProtKB/Swiss-Prot entry P01179

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NEU1_RAT
Primary accession number P01179
Secondary accession number Q53WU2
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on July 1, 1989 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 82)
Name and origin of the protein
Protein name Oxytocin-neurophysin 1 [Precursor]
Synonym OT-NPI
Contains Oxytocin
     (Ocytocin)
Neurophysin 1
Gene name
Name: Oxt
Synonyms: Ot
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1073/pnas.81.7.2006; PubMed=6326097 [NCBI, ExPASy, EBI, Israel, Japan]
Ivell R., Richter D.;
"Structure and comparison of the oxytocin and vasopressin genes from rat.";
Proc. Natl. Acad. Sci. U.S.A. 81:2006-2010(1984).
[2]
 NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3768139 [NCBI, ExPASy, EBI, Israel, Japan]
Rehbein M., Hillers M., Mohr E., Ivell R., Morley S., Schmale H., Richter D.;
"The neurohypophyseal hormones vasopressin and oxytocin. Precursor structure, synthesis and regulation.";
Biol. Chem. Hoppe-Seyler 367:695-704(1986).
[3]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0014-5793(88)81003-2; PubMed=3203740 [NCBI, ExPASy, EBI, Israel, Japan]
Mohr E., Bahnsen U., Kiessling C., Richter D.;
"Expression of the vasopressin and oxytocin genes in rats occurs in mutually exclusive sets of hypothalamic neurons.";
FEBS Lett. 242:144-148(1988).
[4]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Wistar;
TISSUE=Liver;
DOI=10.1089/dna.1991.10.81; PubMed=1706187 [NCBI, ExPASy, EBI, Israel, Japan]
Schmitz E., Mohr E., Richter D.;
"Rat vasopressin and oxytocin genes are linked by a long interspersed repeated DNA element (LINE): sequence and transcriptional analysis of LINE.";
DNA Cell Biol. 10:81-91(1991).
[5]
 PROTEIN SEQUENCE OF 32-125.
DOI=10.1016/0006-291X(81)90493-9; PubMed=7036996 [NCBI, ExPASy, EBI, Israel, Japan]
Chauvet M.-T., Chauvet J., Acher R.;
"Identification of rat neurophysins: complete amino acid sequences of MSEL- and VLDV-neurophysins.";
Biochem. Biophys. Res. Commun. 103:595-603(1981).
[6]
 PROTEIN SEQUENCE OF 32-100.
DOI=10.1016/0014-5793(81)81028-9; PubMed=7238864 [NCBI, ExPASy, EBI, Israel, Japan]
North W.G., Mitchell T.I.;
"Evolution of neurophysin proteins: partial amino acid sequences of rat neurophysins.";
FEBS Lett. 126:41-44(1981).
[7]
 PROTEIN SEQUENCE OF 32-64.
DOI=10.1016/0014-5793(77)80478-X; PubMed=891987 [NCBI, ExPASy, EBI, Israel, Japan]
Schlesinger D.H., Pickering B.T., Watkins W.B., Peek J.C., Moore L.G., Audhya T.K., Walter R.;
"A comparative study of partial neurophysin protein sequences of cod, guinea pig, rat and sheep.";
FEBS Lett. 80:371-373(1977).
[8]
 PROTEIN SEQUENCE OF 20-28.
PubMed=5150741 [NCBI, ExPASy, EBI, Israel, Japan]
Chauvet J., Chauvet M.-T., Acher R.;
"Evolution of neurohypophyseal hormones: isolation of active principles from rabbits and rats.";
Biochimie 53:1099-1104(1971).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
K01701; AAA98733.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M25649; AAA41773.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X12792; CAA31281.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X59496; CAA42085.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00210940; -.
PIR A21183; NFRT1.
RefSeq NP_037128.1; -.
UniGene Rn.48915
3D structure databases
ModBase P01179.
Organism-specific databases
RGD 3238; Oxt.
Gene expression databases
ArrayExpress P01179; -.
GermOnline ENSRNOG00000021225; Rattus norvegicus.
Ontologies
GO
GO:0005615; Cellular component: extracellular space (inferred from direct assay from RGD).
GO:0030141; Cellular component: secretory granule (inferred from direct assay from RGD).
GO:0043195; Cellular component: terminal button (inferred from direct assay from RGD).
GO:0005185; Molecular function: neurohypophyseal hormone activity (inferred from electronic annotation from InterPro).
GO:0031855; Molecular function: oxytocin receptor binding (inferred from direct assay from RGD).
GO:0042756; Biological process: drinking behavior (inferred from direct assay from RGD).
GO:0042755; Biological process: eating behavior (inferred from direct assay from RGD).
GO:0007204; Biological process: elevation of cytosolic calcium ion concentration (inferred from direct assay from RGD).
GO:0007565; Biological process: female pregnancy (inferred from expression pattern from RGD).
GO:0001696; Biological process: gastric acid secretion (inferred from direct assay from RGD).
GO:0007625; Biological process: grooming behavior (inferred from direct assay from RGD).
GO:0007507; Biological process: heart development (inferred from expression pattern from RGD).
GO:0042538; Biological process: hyperosmotic salinity response (inferred from expression pattern from RGD).
GO:0007595; Biological process: lactation (traceable author statement from RGD).
GO:0060179; Biological process: male mating behavior (inferred from expression pattern from RGD).
GO:0002125; Biological process: maternal aggressive behavior (inferred from expression pattern from RGD).
GO:0042711; Biological process: maternal behavior (inferred from direct assay from RGD).
GO:0007613; Biological process: memory (inferred from expression pattern from RGD).
GO:0045776; Biological process: negative regulation of blood pressure (inferred from mutant phenotype from RGD).
GO:0003077; Biological process: negative regulation of diuresis (inferred from direct assay from RGD).
GO:0007567; Biological process: parturition (traceable author statement from RGD).
GO:0045777; Biological process: positive regulation of blood pressure (inferred from direct assay from RGD).
GO:0045925; Biological process: positive regulation of female receptivity (inferred from direct assay from RGD).
GO:0003079; Biological process: positive regulation of natriuresis (inferred from direct assay from RGD).
GO:0010701; Biological process: positive regulation of norepinephrine secretion (inferred from direct assay from RGD).
GO:0045778; Biological process: positive regulation of ossification (inferred from direct assay from RGD).
GO:0060406; Biological process: positive regulation of penile erection (inferred from direct assay from RGD).
GO:0032308; Biological process: positive regulation of prostaglandin secretion (inferred from direct assay from RGD).
GO:0050806; Biological process: positive regulation of synaptic transmission (inferred from direct assay from RGD).
GO:0051965; Biological process: positive regulation of synaptogenesis (inferred from direct assay from RGD).
GO:0070474; Biological process: positive regulation of uterine smooth muscle contraction (inferred from direct assay from RGD).
GO:0044058; Biological process: regulation of digestive system process (inferred from direct assay from RGD).
GO:0002027; Biological process: regulation of heart rate (inferred from direct assay from RGD).
GO:0051930; Biological process: regulation of sensory perception of pain (inferred from direct assay from RGD).
GO:0014823; Biological process: response to activity (inferred from expression pattern from RGD).
GO:0001975; Biological process: response to amphetamine (inferred from expression pattern from RGD).
GO:0051591; Biological process: response to cAMP (inferred from expression pattern from RGD).
GO:0042220; Biological process: response to cocaine (inferred from expression pattern from RGD).
GO:0051602; Biological process: response to electrical stimulus (inferred from expression pattern from RGD).
GO:0032355; Biological process: response to estradiol stimulus (inferred from expression pattern from RGD).
GO:0045472; Biological process: response to ether (inferred from expression pattern from RGD).
GO:0051384; Biological process: response to glucocorticoid stimulus (inferred from expression pattern from RGD).
GO:0043434; Biological process: response to peptide hormone stimulus (inferred from expression pattern from RGD).
GO:0032570; Biological process: response to progesterone stimulus (inferred from direct assay from RGD).
GO:0034695; Biological process: response to prostaglandin E stimulus (inferred from expression pattern from RGD).
GO:0051789; Biological process: response to protein stimulus (inferred from expression pattern from RGD).
GO:0032526; Biological process: response to retinoic acid (inferred from expression pattern from RGD).
GO:0009744; Biological process: response to sucrose stimulus (inferred from expression pattern from RGD).
GO:0030431; Biological process: sleep (inferred from direct assay from RGD).
GO:0035176; Biological process: social behavior (inferred from direct assay from RGD).
GO:0042713; Biological process: sperm ejaculation (inferred from direct assay from RGD).
QuickGo view.
Family and domain databases
InterPro IPR000981; Neurhyp_horm.
IPR016321; Nonapeptide_hormone_prcur.
Graphical view of domain structure.
Gene3D G3DSA:2.60.9.10; Neurhyp_horm; 1.
Pfam PF00220; Hormone_4; 1.
PF00184; Hormone_5; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001815; Nonapeptide_hormone_precursor; 1.
PRINTS PR00831; NEUROPHYSIN.
ProDom PD001676; Neurhyp_horm; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00003; NH; 1.
SMART graphical view of domain structure.
PROSITE PS00264; NEUROHYPOPHYS_HORM; 1.
Genome annotation databases
Ensembl ENSRNOG00000021225; Rattus norvegicus. [Contig view]
GeneID 25504; -.
KEGG rno:25504; -.
Phylogenomic databases
HOVERGEN P01179; -.
OMA P01179; DGCRTDP.
Other
NextBio 606917; -.
PMAP-CutDB P01179; -.
ProtoNet P01179.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amidation; Cleavage on pair of basic residues; Direct protein sequencing; Disulfide bond; Hormone; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    19  19      
PEPTIDE   20    28  9     Oxytocin. PRO_0000020503
CHAIN   32   125  94     Neurophysin 1. PRO_0000020504
MOD_RES   28    28        Glycine amide. 
DISULFID   20    25         
DISULFID   41    85        By similarity. 
DISULFID   44    58        By similarity. 
DISULFID   52    75        By similarity. 
DISULFID   59    65        By similarity. 
DISULFID   92   104        By similarity. 
DISULFID   98   116        By similarity. 
DISULFID   105   110        By similarity. 
CONFLICT   100   100        T -> A (in Ref. 6; AA sequence). 
CONFLICT   124   125        ER -> Q (in Ref. 5; AA sequence). 
Sequence information
Length: 125 AA [This is the length of the unprocessed precursor] Molecular weight: 12823 Da [This is the MW of the unprocessed precursor] CRC64: DC98F90BADC5551F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MACPSLACCL LGLLALTSAC YIQNCPLGGK RAALDLDMRK CLPCGPGGKG RCFGPSICCA 

        70         80         90        100        110        120 
DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAT AGICCSPDGC RTDPACDPES 


AFSER
P01179 in FASTA format

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