ID   NEU1_HUMAN              Reviewed;         125 AA.
AC   P01178; Q3MIG0;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   22-JUL-2008, entry version 87.
DE   RecName: Full=Oxytocin-neurophysin 1;
DE            Short=OT-NPI;
DE   Contains:
DE     RecName: Full=Oxytocin;
DE     AltName: Full=Ocytocin;
DE   Contains:
DE     RecName: Full=Neurophysin 1;
DE   Flags: Precursor;
GN   Name=OXT; Synonyms=OT;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=87026235; PubMed=3768139;
RA   Rehbein M., Hillers M., Mohr E., Ivell R., Morley S., Schmale H.,
RA   Richter D.;
RT   "The neurohypophyseal hormones vasopressin and oxytocin. Precursor
RT   structure, synthesis and regulation.";
RL   Biol. Chem. Hoppe-Seyler 367:695-704(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=85261445; PubMed=2991279;
RA   Sausville E., Carney D., Battey J.;
RT   "The human vasopressin gene is linked to the oxytocin gene and is
RT   selectively expressed in a cultured lung cancer cell line.";
RL   J. Biol. Chem. 260:10236-10241(1985).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RA   Grunwald W.C. Jr., Cool D.R.;
RT   "Lack of sequence polymorphism in the oxytocin gene of autistic
RT   patients.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=21638749; PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA   Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA   Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA   Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA   Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA   Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA   Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA   Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA   Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA   Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA   Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA   Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 25-110.
RX   MEDLINE=91065270; PubMed=2249637;
RA   Ivell R., Furuya K., Brackmann B., Dawood Y., Khan-Dawood F.;
RT   "Expression of the oxytocin and vasopressin genes in human and baboon
RT   gonadal tissues.";
RL   Endocrinology 127:2990-2996(1990).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 80-125.
RX   MEDLINE=86056283; PubMed=4065330; DOI=10.1016/0014-5793(85)80069-7;
RA   Mohr E., Hillers M., Ivell R., Haulica I.D., Richter D.;
RT   "Expression of the vasopressin and oxytocin genes in human
RT   hypothalami.";
RL   FEBS Lett. 193:12-16(1985).
RN   [8]
RP   PROTEIN SEQUENCE OF 32-125.
RX   MEDLINE=83221497; PubMed=6574452;
RA   Chauvet M.-T., Hurpet D., Chauvet J., Acher R.;
RT   "Identification of human neurophysins: complete amino acid sequences
RT   of MSEL- and VLDV-neurophysins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 80:2839-2843(1983).
RN   [9]
RP   PROTEIN SEQUENCE OF 32-125.
RX   MEDLINE=81261248; PubMed=7262323; DOI=10.1016/0014-5793(81)80109-3;
RA   Schlesinger D.H., Audhya T.K.;
RT   "A comparative study of mammalian neurophysin protein sequences.";
RL   FEBS Lett. 128:325-328(1981).
RN   [10]
RP   PROTEIN SEQUENCE OF 20-28.
RX   PubMed=13591312;
RA   Light A., du Vigneaud V.;
RT   "On the nature of oxytocin and vasopressin from human pituitary.";
RL   Proc. Soc. Exp. Biol. Med. 98:692-696(1958).
CC   -!- FUNCTION: Neurophysin 1 specifically binds oxytocin.
CC   -!- FUNCTION: Oxytocin causes contraction of the smooth muscle of the
CC       uterus and of the mammary gland.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PHARMACEUTICAL: Oxytocin is available under the names Pitocin
CC       (Parke-Davis) and Syntocinon (Sandoz). Used to artificially speed
CC       or induce labor.
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Oxytocin entry;
CC       URL="http://en.wikipedia.org/wiki/Oxytocin";
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DR   EMBL; M25650; AAA59977.1; -; mRNA.
DR   EMBL; M11186; AAA98806.1; -; Genomic_DNA.
DR   EMBL; AY082910; AAL92860.1; -; Genomic_DNA.
DR   EMBL; AL160414; CAC10204.1; -; Genomic_DNA.
DR   EMBL; BC069144; AAH69144.1; -; mRNA.
DR   EMBL; BC101841; AAI01842.1; -; mRNA.
DR   EMBL; BC101843; AAI01844.1; -; mRNA.
DR   EMBL; X03173; CAA26936.1; -; mRNA.
DR   EMBL; M62611; AAA59979.1; -; mRNA.
DR   PIR; A94676; NFHU1.
DR   RefSeq; NP_000906.1; -.
DR   UniGene; Hs.113216; -.
DR   PeptideAtlas; P01178; -.
DR   Ensembl; ENSG00000101405; Homo sapiens.
DR   GeneID; 5020; -.
DR   KEGG; hsa:5020; -.
DR   H-InvDB; HIX0040598; -.
DR   HGNC; HGNC:8528; OXT.
DR   MIM; 167050; gene.
DR   PharmGKB; PA32857; -.
DR   HOGENOM; P01178; -.
DR   HOVERGEN; P01178; -.
DR   DrugBank; DB00107; Oxytocin.
DR   LinkHub; P01178; -.
DR   ArrayExpress; P01178; -.
DR   CleanEx; HS_OXT; -.
DR   GermOnline; ENSG00000101405; Homo sapiens.
DR   GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR   InterPro; IPR000981; Neurhyp_horm.
DR   InterPro; IPR016321; Nonapeptide_hormone_prcur.
DR   Gene3D; G3DSA:2.60.9.10; Neurhyp_horm; 1.
DR   Pfam; PF00220; Hormone_4; 1.
DR   Pfam; PF00184; Hormone_5; 1.
DR   PIRSF; PIRSF001815; Nonapeptide_hormone_precursor; 1.
DR   PRINTS; PR00831; NEUROPHYSIN.
DR   ProDom; PD001676; Neurhyp_horm; 1.
DR   SMART; SM00003; NH; 1.
DR   PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues;
KW   Direct protein sequencing; Hormone; Pharmaceutical; Secreted; Signal.
FT   SIGNAL        1     19
FT   PEPTIDE      20     28       Oxytocin.
FT                                /FTId=PRO_0000020495.
FT   CHAIN        32    125       Neurophysin 1.
FT                                /FTId=PRO_0000020496.
FT   MOD_RES      28     28       Glycine amide.
FT   DISULFID     20     25
FT   DISULFID     41     85       By similarity.
FT   DISULFID     44     58       By similarity.
FT   DISULFID     52     75       By similarity.
FT   DISULFID     59     65       By similarity.
FT   DISULFID     92    104       By similarity.
FT   DISULFID     98    116       By similarity.
FT   DISULFID    105    110       By similarity.
FT   CONFLICT     94     94       S -> G (in Ref. 6; AAA59979).
FT   CONFLICT    100    101       VL -> AA (in Ref. 9; AA sequence).
FT   CONFLICT    100    100       Missing (in Ref. 2; AAA98806).
FT   CONFLICT    124    124       Q -> L (in Ref. 9; AA sequence).
SQ   SEQUENCE   125 AA;  12722 MW;  C65BB544731A0E7C CRC64;
     MAGPSLACCL LGLLALTSAC YIQNCPLGGK RAAPDLDVRK CLPCGPGGKG RCFGPNICCA
     EELGCFVGTA EALRCQEENY LPSPCQSGQK ACGSGGRCAV LGLCCSPDGC HADPACDAEA
     TFSQR
//