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UniProtKB/Swiss-Prot entry P01178


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NEU1_HUMAN
Primary accession number P01178
Secondary accession number Q3MIG0
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on January 1, 1988 (Sequence version 1)
Annotations were last modified on    April 29, 2008 (Entry version 85)
Name and origin of the protein
Protein name Oxytocin-neurophysin 1 [Precursor]
Synonym OT-NPI
Contains Oxytocin
     (Ocytocin)
Neurophysin 1
Gene name
Name: OXT
Synonyms: OT
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE.
PubMed=3768139 [NCBI, ExPASy, EBI, Israel, Japan]
Rehbein M., Hillers M., Mohr E., Ivell R., Morley S., Schmale H., Richter D.;
"The neurohypophyseal hormones vasopressin and oxytocin. Precursor structure, synthesis and regulation.";
Biol. Chem. Hoppe-Seyler 367:695-704(1986).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2991279 [NCBI, ExPASy, EBI, Israel, Japan]
Sausville E., Carney D., Battey J.;
"The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line.";
J. Biol. Chem. 260:10236-10241(1985).
[3]
NUCLEOTIDE SEQUENCE.
Grunwald W.C. Jr., Cool D.R.;
"Lack of sequence polymorphism in the oxytocin gene of autistic patients.";
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/414865a; PubMed=11780052 [NCBI, ExPASy, EBI, Israel, Japan]
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 20.";
Nature 414:865-871(2001).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
NUCLEOTIDE SEQUENCE [MRNA] OF 25-110.
PubMed=2249637 [NCBI, ExPASy, EBI, Israel, Japan]
Ivell R., Furuya K., Brackmann B., Dawood Y., Khan-Dawood F.;
"Expression of the oxytocin and vasopressin genes in human and baboon gonadal tissues.";
Endocrinology 127:2990-2996(1990).
[7]
NUCLEOTIDE SEQUENCE [MRNA] OF 80-125.
DOI=10.1016/0014-5793(85)80069-7; PubMed=4065330 [NCBI, ExPASy, EBI, Israel, Japan]
Mohr E., Hillers M., Ivell R., Haulica I.D., Richter D.;
"Expression of the vasopressin and oxytocin genes in human hypothalami.";
FEBS Lett. 193:12-16(1985).
[8]
PROTEIN SEQUENCE OF 32-125.
PubMed=6574452 [NCBI, ExPASy, EBI, Israel, Japan]
Chauvet M.-T., Hurpet D., Chauvet J., Acher R.;
"Identification of human neurophysins: complete amino acid sequences of MSEL- and VLDV-neurophysins.";
Proc. Natl. Acad. Sci. U.S.A. 80:2839-2843(1983).
[9]
PROTEIN SEQUENCE OF 32-125.
DOI=10.1016/0014-5793(81)80109-3; PubMed=7262323 [NCBI, ExPASy, EBI, Israel, Japan]
Schlesinger D.H., Audhya T.K.;
"A comparative study of mammalian neurophysin protein sequences.";
FEBS Lett. 128:325-328(1981).
[10]
PROTEIN SEQUENCE OF 20-28.
PubMed=13591312 [NCBI, ExPASy, EBI, Israel, Japan]
Light A., du Vigneaud V.;
"On the nature of oxytocin and vasopressin from human pituitary.";
Proc. Soc. Exp. Biol. Med. 98:692-696(1958).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M25650; AAA59977.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M11186; AAA98806.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY082910; AAL92860.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL160414; CAC10204.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC069144; AAH69144.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC101841; AAI01842.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC101843; AAI01844.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X03173; CAA26936.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M62611; AAA59979.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A94676; NFHU1.
RefSeq NP_000906.1; -.
UniGene Hs.113216
3D structure databases
ModBase P01178.
Organism-specific databases
H-InvDB HIX0040598; -.
HGNC HGNC:8528; OXT.
GeneLynx OXT; Homo sapiens.
GenAtlas OXT.
MIM 167050; gene. [NCBI / EBI]
PharmGKB PA32857; -.
GeneCards P01178.
Gene expression databases
ArrayExpress P01178; -.
CleanEx HS_OXT; -.
GermOnline ENSG00000101405; Homo sapiens.
Ontologies
GO
GO:0007165; Biological process: signal transduction (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR000981; Neurhyp_horm.
IPR016321; Nonapeptide_hormone_prcur.
Graphical view of domain structure.
Gene3D G3DSA:2.60.9.10; Neurhyp_horm; 1.
Pfam PF00220; Hormone_4; 1.
PF00184; Hormone_5; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001815; Nonapeptide_hormone_precursor; 1.
PRINTS PR00831; NEUROPHYSIN.
ProDom PD001676; Neurhyp_horm; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00003; NH; 1.
SMART graphical view of domain structure.
PROSITE PS00264; NEUROHYPOPHYS_HORM; 1.
BLOCKS P01178.
Proteomic databases
PeptideAtlas P01178; -.
Genome annotation databases
Ensembl ENSG00000101405; Homo sapiens. [Contig view]
GeneID 5020; -.
KEGG hsa:5020; -.
Other
DrugBank DB00107; Oxytocin.
LinkHub P01178; -.
SOURCE OXT; Homo sapiens.
ProtoNet P01178.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amidation; Cleavage on pair of basic residues; Direct protein sequencing; Hormone; Pharmaceutical; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    19  19      
PEPTIDE   20    28  9     Oxytocin. PRO_0000020495
CHAIN   32   125  94     Neurophysin 1. PRO_0000020496
MOD_RES   28    28        Glycine amide. 
DISULFID   20    25         
DISULFID   41    85        By similarity. 
DISULFID   44    58        By similarity. 
DISULFID   52    75        By similarity. 
DISULFID   59    65        By similarity. 
DISULFID   92   104        By similarity. 
DISULFID   98   116        By similarity. 
DISULFID   105   110        By similarity. 
CONFLICT   94    94        S -> G (in Ref. 6; AAA59979). 
CONFLICT   100   101        VL -> AA (in Ref. 9; AA sequence). 
CONFLICT   100   100        Missing (in Ref. 2; AAA98806). 
CONFLICT   124   124        Q -> L (in Ref. 9; AA sequence). 
Sequence information
Length: 125 AA [This is the length of the unprocessed precursor] Molecular weight: 12722 Da [This is the MW of the unprocessed precursor] CRC64: C65BB544731A0E7C [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAGPSLACCL LGLLALTSAC YIQNCPLGGK RAAPDLDVRK CLPCGPGGKG RCFGPNICCA 

        70         80         90        100        110        120 
EELGCFVGTA EALRCQEENY LPSPCQSGQK ACGSGGRCAV LGLCCSPDGC HADPACDAEA 


TFSQR 

P01178 in FASTA format

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