[1]
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PROTEIN SEQUENCE.
Dodt J.,
Mueller H.-P.,
Seemueller U.,
Chang J.-Y.;
"The complete amino acid sequence of hirudin, a thrombin specific inhibitor. Application of colour carboxymethylation.";
FEBS Lett. 165:180-183(1984).
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[2]
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PROTEIN SEQUENCE.
Petersen T.E.,
Roberts H.R.,
Sottrup-Jensen L.,
Magnusson S.,
Bagdy D.;
(In) Peeters H. (eds.); Protides of the biological fluids, Proc. 23th colloquium, pp.145-149, Pergamon Press, New York (1976).
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[3]
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PROTEIN SEQUENCE OF 1-17 AND 28-65.
DOI=10.1016/0014-5793(89)81070-1; PubMed=2792365 [NCBI, ExPASy, EBI, Israel, Japan]
Scharf M.,
Engels J.,
Tripier D.;
"Primary structures of new 'iso-hirudins'.";
FEBS Lett. 255:105-110(1989).
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[4]
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MUTAGENESIS OF PHE-56; PRO-60 AND TYR-63.
DOI=10.1021/bi00105a006; PubMed=1911777 [NCBI, ExPASy, EBI, Israel, Japan]
Betz A.,
Hofsteenge J.,
Stone S.R.;
"Role of interactions involving C-terminal nonpolar residues of hirudin in the formation of the thrombin-hirudin complex.";
Biochemistry 30:9848-9853(1991).
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[5]
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MUTAGENESIS OF VAL-1; VAL-2; TYR-3; THR-4 AND ASP-5.
DOI=10.1021/bi00134a004; PubMed=1581311 [NCBI, ExPASy, EBI, Israel, Japan]
Betz A.,
Hofsteenge J.,
Stone S.R.;
"Interaction of the N-terminal region of hirudin with the active-site cleft of thrombin.";
Biochemistry 31:4557-4562(1992).
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[6]
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MUTAGENESIS OF LEU-15; ASN-20 AND VAL-21.
PubMed=8135762 [NCBI, ExPASy, EBI, Israel, Japan]
Betz A.,
Hopkins P.C.R.,
Le Bonniec B.F.,
Stone S.R.;
"Contribution of interactions with the core domain of hirudin to the stability of its complex with thrombin.";
Biochem. J. 298:507-510(1994).
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[7]
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STRUCTURE BY NMR, AND DISULFIDE BONDS.
DOI=10.1021/bi00432a038; PubMed=2567183 [NCBI, ExPASy, EBI, Israel, Japan]
Folkers P.J.M.,
Clore G.M.,
Driscoll P.C.,
Dodt J.,
Koehler S.,
Gronenborn A.M.;
"Solution structure of recombinant hirudin and the Lys-47-->Glu mutant: a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study.";
Biochemistry 28:2601-2617(1989).
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[8]
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STRUCTURE BY NMR.
DOI=10.1021/bi00436a027; PubMed=2765488 [NCBI, ExPASy, EBI, Israel, Japan]
Haruyama H.,
Wuethrich K.;
"Conformation of recombinant desulfatohirudin in aqueous solution determined by nuclear magnetic resonance.";
Biochemistry 28:4301-4312(1989).
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[9]
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X-RAY CRYSTALLOGRAPHY (2.95 ANGSTROMS) IN COMPLEX WITH THROMBIN.
PubMed=2369893 [NCBI, ExPASy, EBI, Israel, Japan]
Gruetter M.G.,
Priestle J.P.,
Rahuel J.,
Grossenbacher H.,
Bode W.,
Hofsteenge J.,
Stone S.R.;
"Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition.";
EMBO J. 9:2361-2365(1990).
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[10]
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X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 51-65 IN COMPLEX WITH THROMBIN.
PubMed=1517214 [NCBI, ExPASy, EBI, Israel, Japan]
Vitali J.,
Martin P.D.,
Malkowski M.G.,
Robertson W.D.,
Lazar J.B.,
Winant R.C.,
Johnson P.H.,
Edwards B.F.P.;
"The structure of a complex of bovine alpha-thrombin and recombinant hirudin at 2.8-A resolution.";
J. Biol. Chem. 267:17670-17678(1992).
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[11]
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STRUCTURE BY NMR OF 1-51.
DOI=10.1016/0022-2836(92)90325-E; PubMed=1335515 [NCBI, ExPASy, EBI, Israel, Japan]
Szyperski T.,
Guentert P.,
Stone S.R.,
Wuethrich K.;
"Nuclear magnetic resonance solution structure of hirudin(1-51) and comparison with corresponding three-dimensional structures determined using the complete 65-residue hirudin polypeptide chain.";
J. Mol. Biol. 228:1193-1205(1992).
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[12]
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X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 54-65 IN COMPLEX WITH THROMBIN, AND SULFATION AT TYR-63.
PubMed=8251938 [NCBI, ExPASy, EBI, Israel, Japan]
Priestle J.P.,
Rahuel J.,
Rink H.,
Tones M.,
Gruetter M.G.;
"Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms.";
Protein Sci. 2:1630-1642(1993).
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[13]
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STRUCTURE BY NMR OF 1-57 OF MUTANT 32-R--D-34, FUNCTION, AND DISULFIDE BONDS.
DOI=10.1016/j.bbrc.2007.06.014; PubMed=17585879 [NCBI, ExPASy, EBI, Israel, Japan]
Song X.,
Mo W.,
Liu X.,
Zhu L.,
Yan X.,
Song H.,
Dai L.;
"The NMR solution structure of recombinant RGD-hirudin.";
Biochem. Biophys. Res. Commun. 360:103-108(2007).
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[14]
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X-RAY CRYSTALLOGRAPHY (1.84 ANGSTROMS), DISULFIDE BONDS, AND SULFATION AT TYR-63.
DOI=10.1021/ja0735002; PubMed=17685615 [NCBI, ExPASy, EBI, Israel, Japan]
Liu C.C.,
Brustad E.,
Liu W.,
Schultz P.G.;
"Crystal structure of a biosynthetic sulfo-hirudin complexed to thrombin.";
J. Am. Chem. Soc. 129:10648-10649(2007).
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