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UniProtKB/Swiss-Prot entry P01029


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CO4B_MOUSE
Primary accession number P01029
Secondary accession numbers O70346 Q31201 Q3TYY1 Q3TZC9 Q61372 Q61859 Q62353 Q6NWV8
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on February 20, 2007 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 96)
Name and origin of the protein
Protein name Complement C4-B [Precursor]
Synonyms None
Contains Complement C4 beta chain
Complement C4 alpha chain
C4a anaphylatoxin
Complement C4 gamma chain
Gene name
Name: C4b
Synonyms: C4
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=FM;
PubMed=2993295 [NCBI, ExPASy, EBI, Israel, Japan]
Nonaka M., Nakayama K., Yeul Y.D., Takahashi M.;
"Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.";
J. Biol. Chem. 260:10936-10943(1985).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=B10.WR;
PubMed=3862104 [NCBI, ExPASy, EBI, Israel, Japan]
Sepich D.S., Noonan D.J., Ogata R.T.;
"Complete cDNA sequence of the fourth component of murine complement.";
Proc. Natl. Acad. Sci. U.S.A. 82:5895-5899(1985).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=B10.WR;
PubMed=2777798 [NCBI, ExPASy, EBI, Israel, Japan]
Ogata R.T., Rosa P.A., Zepf N.E.;
"Sequence of the gene for murine complement component C4.";
J. Biol. Chem. 264:16565-16572(1989).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=129;
DOI=10.1101/gr.1736803; PubMed=14656967 [NCBI, ExPASy, EBI, Israel, Japan]
Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.;
"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.";
Genome Res. 13:2621-2636(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
TISSUE=Inner ear;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J, and CD-1;
TISSUE=Germ cell, and Neural stem cell;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-128.
STRAIN=FM;
PubMed=2997024 [NCBI, ExPASy, EBI, Israel, Japan]
Nonaka M., Nakayama K., Yeul Y.D., Shimizu A., Takahashi M.;
"Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.";
Immunol. Rev. 87:81-99(1985).
[8]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21.
PubMed=3464002 [NCBI, ExPASy, EBI, Israel, Japan]
Nonaka M., Kimura H., Yeul Y.D., Yokoyama S., Nakayama K., Takahashi M.;
"Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.";
Proc. Natl. Acad. Sci. U.S.A. 83:7883-7887(1986).
[9]
NUCLEOTIDE SEQUENCE [MRNA] OF 591-1738.
STRAIN=C57BL/10 X DBA/2;
DOI=10.1093/nar/14.6.2539; PubMed=3008092 [NCBI, ExPASy, EBI, Israel, Japan]
Hemenway C., Kalff M., Stavenhagen J., Walthall D., Robins D.;
"Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp).";
Nucleic Acids Res. 14:2539-2554(1986).
[10]
NUCLEOTIDE SEQUENCE [MRNA] OF 651-810 AND 924-1083.
PubMed=6208559 [NCBI, ExPASy, EBI, Israel, Japan]
Nonaka M., Takahashi M., Natsuume-Sakai S., Nonaka M., Tanaka S., Shimizu A., Honjo T.;
"Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.";
Proc. Natl. Acad. Sci. U.S.A. 81:6822-6826(1984).
[11]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 961-1290.
PubMed=2459207 [NCBI, ExPASy, EBI, Israel, Japan]
Taillon-Miller P.A., Shreffler D.C.;
"Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.";
J. Immunol. 141:2382-2387(1988).
[12]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1099-1142.
STRAIN=B10.BR, B10.WR, C3H/He, C57BL/6, CBA/J, and DBA/2;
PubMed=2387317 [NCBI, ExPASy, EBI, Israel, Japan]
Ogata R.T., Zepf N.E.;
"C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.";
Eur. J. Immunol. 20:1607-1610(1990).
[13]
NUCLEOTIDE SEQUENCE [MRNA] OF 1105-1449.
PubMed=3856857 [NCBI, ExPASy, EBI, Israel, Japan]
Levi-Strauss M., Tosi M., Steinmetz M., Klein J., Meo T.;
"Multiple duplications of complement C4 gene correlate with H-2-controlled testosterone-independent expression of its sex-limited isoform, C4-Slp.";
Proc. Natl. Acad. Sci. U.S.A. 82:1746-1750(1985).
[14]
NUCLEOTIDE SEQUENCE [MRNA] OF 1257-1376.
PubMed=6149581 [NCBI, ExPASy, EBI, Israel, Japan]
Tosi M., Levi-Strauss M., Duponchel C., Meo T.;
"Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.";
Philos. Trans. R. Soc. Lond., B, Biol. Sci. 306:389-394(1984).
[15]
NUCLEOTIDE SEQUENCE [MRNA] OF 1360-1511.
PubMed=6192448 [NCBI, ExPASy, EBI, Israel, Japan]
Ogata R.T., Shreffler D.C., Sepich D.S., Lilly S.P.;
"cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).";
Proc. Natl. Acad. Sci. U.S.A. 80:5061-5065(1983).
[16]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1324, AND MASS SPECTROMETRY.
TISSUE=Plasma;
DOI=10.1021/pr0604559; PubMed=17330941 [NCBI, ExPASy, EBI, Israel, Japan]
Bernhard O.K., Kapp E.A., Simpson R.J.;
"Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides.";
J. Proteome Res. 6:987-995(2007).
Comments
  • FUNCTION: C4 plays a central role in the activation of the classical pathway of the complement system. It is processed by activated C1 which removes from the alpha chain the C4a anaphylatoxin. The remaining alpha chain fragment C4b is the major activation product and is an essential subunit of the C3 convertase (C4b2a) and the C5 convertase (C3bC4b2a) enzymes of the classical complement pathway.
  • SUBUNIT: Circulates in blood as a disulfide-linked trimer of an alpha, beta and gamma chain.
  • SUBCELLULAR LOCATION: Secreted.
  • PTM: Prior to secretion, the single-chain precursor is enzymatically cleaved to yield the non-identical chains (alpha, beta and gamma). During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase.
  • MISCELLANEOUS: C4 is a major histocompatibility complex class-III protein.
  • SIMILARITY: Contains 1 anaphylatoxin-like domain.
  • SIMILARITY: Contains 1 NTR domain.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M11789; AAA39557.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M11729; AAA39506.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M17440; AAA39561.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF049850; AAC05279.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK157954; BAE34280.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK158256; BAE34429.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC067394; AAH67394.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC067409; AAH67409.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M12969; AAA39559.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M14225; AAA39563.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X05314; CAA28936.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M12970; AAA39555.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M12972; AAA39556.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M23186; AAA40487.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X55493; CAA39112.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X55495; CAA39114.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
K02798; AAC42021.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
K02799; AAC42022.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
K00019; AAA39554.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M12968; AAA39558.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A24558; A24558.
A29176; A29176.
RefSeq NP_033910.2; -.
UniGene Mm.439678
3D structure databases
HSSP P01031; 1KJS. [HSSP ENTRY / PDB]
SMR P01029; 992-1317.
ModBase P01029.
Protein family/group databases
MEROPS I39.951; -.
Organism-specific databases
MGI MGI:88228; C4b.
Gene expression databases
ArrayExpress P01029; -.
CleanEx MM_C4B; -.
GermOnline ENSMUSG00000073418; Mus musculus.
Ontologies
GO
GO:0006956; Biological process: complement activation (inferred from mutant phenotype from MGI).
GO:0016064; Biological process: immunoglobulin mediated immune response (inferred from mutant phenotype from MGI).
QuickGo view.
Family and domain databases
InterPro IPR009048; A-macroglobulin_rcpt-bd.
IPR011626; A2M_comp.
IPR002890; A2M_N.
IPR011625; A2M_N_2.
IPR000020; Anaphylatoxin.
IPR001840; Anaphylatoxn.
IPR001599; MacrogloblnA2.
IPR001134; Netrin_C.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.690; A-macroglobulin_rcpt-bd; 1.
G3DSA:1.20.91.20; Anaphylatoxin; 1.
Pfam PF00207; A2M; 1.
PF07678; A2M_comp; 1.
PF01835; A2M_N; 1.
PF07703; A2M_N_2; 1.
PF07677; A2M_recep; 1.
PF01821; ANATO; 1.
PF01759; NTR; 1.
Pfam graphical view of domain structure.
PRINTS PR00004; ANAPHYLATOXN.
ProDom PD003264; Anaphylatoxin; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00104; ANATO; 1.
SM00643; C345C; 1.
SMART graphical view of domain structure.
PROSITE PS00477; ALPHA_2_MACROGLOBULIN; 1.
PS01177; ANAPHYLATOXIN_1; 1.
PS01178; ANAPHYLATOXIN_2; 1.
PS50189; NTR; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P01029.
ProtoNet P01029.
Genome annotation databases
Ensembl ENSMUSG00000073418; Mus musculus. [Contig view]
GeneID 12268; -.
KEGG mmu:12268; -.
Phylogenomic databases
HOVERGEN P01029; -.
Other
NextBio 280722; -.
SOURCE C4b; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cleavage on pair of basic residues; Complement pathway; Glycoprotein; Immune response; Inflammatory response; Innate immunity; Secreted; Signal; Sulfation; Thioester bond.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
SIGNAL   1     19  19      
CHAIN   20    673  654     Complement C4 beta chain. PRO_0000005973
PROPEP   674    677  4      PRO_0000005974
CHAIN   678   1443  766     Complement C4 alpha chain. PRO_0000005975
CHAIN   678    753  76     C4a anaphylatoxin. PRO_0000005976
PROPEP   1444   1447  4      PRO_0000005977
CHAIN   1448   1738  291     Complement C4 gamma chain. PRO_0000005978
DOMAIN   700    734  35     Anaphylatoxin-like. 
DOMAIN   1589   1736  148     NTR. 
MOD_RES   1413   1413        Sulfotyrosine. 
MOD_RES   1416   1416        Sulfotyrosine. 
MOD_RES   1417   1417        Sulfotyrosine. 
CARBOHYD   224    224        N-linked (GlcNAc...) (Potential). 
CARBOHYD   743    743        N-linked (GlcNAc...). 
CARBOHYD   1324   1324        N-linked (GlcNAc...). 
CARBOHYD   1387   1387        N-linked (GlcNAc...) (Potential). 
DISULFID   700    726        By similarity. 
DISULFID   701    733        By similarity. 
DISULFID   714    734        By similarity. 
DISULFID   1589   1667        By similarity. 
DISULFID   1612   1736        By similarity. 
CROSSLNK   1006   1009        Isoglutamyl cysteine thioester (Cys-Gln) (By similarity). 
CONFLICT   132    132        F -> Y (in Ref. 3; AAA39557). 
CONFLICT   177    177        E -> G (in Ref. 5; BAE34429). 
CONFLICT   283    283        A -> V (in Ref. 5; BAE34429). 
CONFLICT   327    327        G -> E (in Ref. 3; AAA39557). 
CONFLICT   440    440        E -> K (in Ref. 6; AAH67409/AAH67394). 
CONFLICT   570    570        Q -> E (in Ref. 3; AAA39557 and 5; BAE34280). 
CONFLICT   604    604        T -> M (in Ref. 4; AAC05279 and 9; CAA28936). 
CONFLICT   639    639        D -> G (in Ref. 5; BAE34429). 
CONFLICT   720    720        R -> G (in Ref. 10). 
CONFLICT   739    740        DL -> AI (in Ref. 10). 
CONFLICT   758    758        M -> I (in Ref. 5; BAE34280). 
CONFLICT   838    838        P -> R (in Ref. 3; AAA39557). 
CONFLICT   916    916        V -> I (in Ref. 5; BAE34280). 
CONFLICT   993    993        P -> L (in Ref. 10). 
CONFLICT   1043   1043        D -> E (in Ref. 10). 
CONFLICT   1077   1077        F -> S (in Ref. 6; AAH67409/AAH67394). 
CONFLICT   1119   1119        V -> A (in Ref. 13; AAC42021). 
CONFLICT   1190   1190        A -> T (in Ref. 13; AAC42021). 
CONFLICT   1206   1206        R -> Q (in Ref. 11, 5; BAE34429/BAE34280 and 6; AAH67409/AAH67394). 
CONFLICT   1290   1290        S -> N (in Ref. 14; AAC42022). 
CONFLICT   1324   1324        N -> K (in Ref. 1; AAA39506, 2; AAA39561 and 13; AAC42021). 
CONFLICT   1365   1365        K -> E (in Ref. 5; BAE34429). 
CONFLICT   1401   1401        G -> S (in Ref. 15; AAA39554). 
CONFLICT   1442   1442        R -> K (in Ref. 3; AAA39557). 
CONFLICT   1453   1453        V -> A (in Ref. 1; AAA39506, 2; AAA39561, 5; BAE34429 and 15; AAA39554). 
CONFLICT   1456   1456        Q -> R (in Ref. 5; BAE34429). 
CONFLICT   1586   1586        E -> Q (in Ref. 9; CAA28936). 
CONFLICT   1611   1611        A -> T (in Ref. 4; AAC05279). 
Sequence information
Length: 1738 AA [This is the length of the unprocessed precursor] Molecular weight: 192885 Da [This is the MW of the unprocessed precursor] CRC64: B249D52195D5AF10 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MRLLWGLAWV FSFCASSLQK PRLLLFSPSV VNLGTPLSVG VQLLDAPPGQ EVKGSVFLRN 

        70         80         90        100        110        120 
PKGGSCSPKK DFKLSSGDDF VLLSLEVPLE DVRSCGLFDL RRAPHIQLVA QSPWLRNTAF 

       130        140        150        160        170        180 
KATETQGVNL LFSSRRGHIF VQTDQPIYNP GQRVRYRVFA LDQKMRPSTD FLTITVENSH 

       190        200        210        220        230        240 
GLRVLKKEIF TSTSIFQDAF TIPDISEPGT WKISARFSDG LESNRSTHFE VKKYVLPNFE 

       250        260        270        280        290        300 
VKITPWKPYI LMVPSNSDEI QLDIQARYIY GKPVQGVAYT RFALMDEQGK RTFLRGLETQ 

       310        320        330        340        350        360 
AKLVEGRTHI SISKDQFQAA LDKINIGVRD LEGLRLYAAT AVIESPGGEM EEAELTSWRF 

       370        380        390        400        410        420 
VSSAFSLDLS RTKRHLVPGA HFLLQALVQE MSGSEASNVP VKVSATLVSG SDSQVLDIQQ 

       430        440        450        460        470        480 
STNGIGQVSI SFPIPPTVTE LRLLVSAGSL YPAIARLTVQ APPSRGTGFL SIEPLDPRSP 

       490        500        510        520        530        540 
SVGDTFILNL QPVGIPAPTF SHYYYMIISR GQIMAMGREP RKTVTSVSVL VDHQLAPSFY 

       550        560        570        580        590        600 
FVAYFYHQGH PVANSLLINI QSRDCEGKLQ LKVDGAKEYR NADMMKLRIQ TDSKALVALG 

       610        620        630        640        650        660 
AVDTALYAVG GRSHKPLDMS KVFEVINSYN VGCGPGGGDD ALQVFQDAGL AFSDGDRLTQ 

       670        680        690        700        710        720 
TREDLSCPKE KKSRQKRNVN FQKAVSEKLG QYSSPDAKRC CQDGMTKLPM KRTCEQRAAR 

       730        740        750        760        770        780 
VPQQACREPF LSCCKFAEDL RRNQTRSQAH LARNNHNMLQ EEDLIDEDDI LVRTSFPENW 

       790        800        810        820        830        840 
LWRVEPVDSS KLLTVWLPDS MTTWEIHGVS LSKSKGLCVA KPTRVRVFRK FHLHLRLPIS 

       850        860        870        880        890        900 
IRRFEQFELR PVLYNYLNDD VAVSVHVTPV EGLCLAGGGM MAQQVTVPAG SARPVAFSVV 

       910        920        930        940        950        960 
PTAAANVPLK VVARGVFDLG DAVSKILQIE KEGAIHREEL VYNLDPLNNL GRTLEIPGSS 

       970        980        990       1000       1010       1020 
DPNIVPDGDF SSLVRVTASE PLETMGSEGA LSPGGVASLL RLPQGCAEQT MIYLAPTLTA 

      1030       1040       1050       1060       1070       1080 
SNYLDRTEQW SKLSPETKDH AVDLIQKGYM RIQQFRKNDG SFGAWLHRDS STWLTAFVLK 

      1090       1100       1110       1120       1130       1140 
ILSLAQEQVG NSPEKLQETA SWLLAQQLGD GSFHDPCPVI HRAMQGGLVG SDETVALTAF 

      1150       1160       1170       1180       1190       1200 
VVIALHHGLD VFQDDDAKQL KNRVEASITK ANSFLGQKAS AGLLGAHAAA ITAYALTLTK 

      1210       1220       1230       1240       1250       1260 
ASEDLRNVAH NSLMAMAEET GEHLYWGLVL GSQDKVVLRP TAPRSPTEPV PQAPALWIET 

      1270       1280       1290       1300       1310       1320 
TAYALLHLLL REGKGKMADK AASWLTHQGS FHGAFRSTQD TVVTLDALSA YWIASHTTEE 

      1330       1340       1350       1360       1370       1380 
KALNVTLSSM GRNGLKTHGL HLNNHQVKGL EEELKFSLGS TISVKVEGNS KGTLKILRTY 

      1390       1400       1410       1420       1430       1440 
NVLDMKNTTC QDLQIEVKVT GAVEYAWDAN EDYEDYYDMP AADDPSVPLQ PVTPLQLFEG 

      1450       1460       1470       1480       1490       1500 
RRSRRRREAP KVVEEQESRV QYTVCIWRNG KLGLSGMAIA DITLLSGFHA LRADLEKLTS 

      1510       1520       1530       1540       1550       1560 
LSDRYVSHFE TDGPHVLLYF DSVPTTRECV GFGASQEVVV GLVQPSSAVL YDYYSPDHKC 

      1570       1580       1590       1600       1610       1620 
SVFYAAPTKS QLLATLCSGD VCQCAEGKCP RLLRSLERRV EDKDGYRMRF ACYYPRVEYG 

      1630       1640       1650       1660       1670       1680 
FTVKVLREDG RAAFRLFESK ITQVLHFRKD TMASIGQTRN FLSRASCRLR LEPNKEYLIM 

      1690       1700       1710       1720       1730 
GMDGETSDNK GDPQYLLDSN TWIEEMPSEQ MCKSTRHRAA CFQLKDFLME FSSRGCQV 

P01029 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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