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UniProtKB/Swiss-Prot entry P00936


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CYAA_ECOLI
Primary accession number P00936
Secondary accession number Q2M8B1
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on June 20, 2003 (Sequence version 5)
Annotations were last modified on    November 4, 2008 (Entry version 79)
Name and origin of the protein
Protein name Adenylate cyclase
Synonyms EC 4.6.1.1
ATP pyrophosphate-lyase
Adenylyl cyclase
Gene name
Name: cyaA
Synonyms: cya
OrderedLocusNames: b3806, JW3778
From
Escherichia coli (strain K12) [TaxID: 83333] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1093/nar/12.24.9427; PubMed=6393056 [NCBI, ExPASy, EBI, Israel, Japan]
Aiba H., Mori K., Tanaka M., Ooi T., Roy A., Danchin A.;
"The complete nucleotide sequence of the adenylate cyclase gene of Escherichia coli.";
Nucleic Acids Res. 12:9427-9440(1984).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2982847 [NCBI, ExPASy, EBI, Israel, Japan]
Aiba H.;
"Transcription of the Escherichia coli adenylate cyclase gene is negatively regulated by cAMP-cAMP receptor protein.";
J. Biol. Chem. 260:3063-3070(1985).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0300-9084(96)82192-4; PubMed=8874804 [NCBI, ExPASy, EBI, Israel, Japan]
Trotot P., Sismeiro O., Vivares C., Glaser P., Bresson-Roy A., Danchin A.;
"Comparative analysis of the cya locus in enterobacteria and related Gram-negative facultative anaerobes.";
Biochimie 78:277-287(1996).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=1379743 [NCBI, ExPASy, EBI, Israel, Japan]
Daniels D.L., Plunkett G. III, Burland V.D., Blattner F.R.;
"Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes.";
Science 257:771-778(1992).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
DOI=10.1126/science.277.5331.1453; PubMed=9278503 [NCBI, ExPASy, EBI, Israel, Japan]
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.;
"The complete genome sequence of Escherichia coli K-12.";
Science 277:1453-1474(1997).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
DOI=10.1038/msb4100049; PubMed=16738553 [NCBI, ExPASy, EBI, Israel, Japan]
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.";
Mol. Syst. Biol. 2:E1-E5(2006).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-183.
PubMed=6357786 [NCBI, ExPASy, EBI, Israel, Japan]
Roy A., Haziza C., Danchin A.;
"Regulation of adenylate cyclase synthesis in Escherichia coli: nucleotide sequence of the control region.";
EMBO J. 2:791-797(1983).
[8]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-88.
DOI=10.1093/nar/11.11.3451; PubMed=6344011 [NCBI, ExPASy, EBI, Israel, Japan]
Aiba H., Kawamukai M., Ishihama A.;
"Cloning and promoter analysis of the Escherichia coli adenylate cyclase gene.";
Nucleic Acids Res. 11:3451-3465(1983).
[9]
REVIEW.
PubMed=8418825 [NCBI, ExPASy, EBI, Israel, Japan]
Danchin A.;
"Phylogeny of adenylyl cyclases.";
Adv. Second Messenger Phosphoprotein Res. 27:109-162(1993).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X01653; CAA25817.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X66782; CAA47280.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M87049; AAA67602.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U00096; AAC76809.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AP009048; BAE77495.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR G65184; OYEC.
RefSeq AP_003994.1; -.
NP_418250.1; -.
3D structure databases
ModBase P00936.
Enzyme and pathway databases
BioCyc EcoCyc:ADENYLATECYC-MON; -.
MetaCyc:ADENYLATECYC-MON; -.
Organism-specific databases
EchoBASE EB0168; -.
EcoGene EG10170; cyaA.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000274; Adenylt_cyclse_1.
Graphical view of domain structure.
Pfam PF01295; Adenylate_cycl; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001444; Adenylate_cycl; 1.
PROSITE PS01092; ADENYLATE_CYCLASE_1_1; 1.
PS01093; ADENYLATE_CYCLASE_1_2; 1.
BLOCKS P00936.
ProtoNet P00936.
Genome annotation databases
GeneID 947755; -.
GenomeReviews U00096_GR; b3806.
AP009048_GR; JW3778.
KEGG ecj:JW3778; -.
eco:b3806; -.
Phylogenomic databases
HOGENOM P00936; -.
Genome annotation databases
CMR P00936; b3806.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
cAMP biosynthesis; Complete proteome; Cytoplasm; Lyase; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   848  848     Adenylate cyclase. PRO_0000195669
REGION   1   535  535     Catalytic. 
REGION   541   848  308     Regulatory. 
MOD_RES   609   609        Phosphohistidine; by CRR (Potential). 
CONFLICT   223   223        V -> G (in Ref. 1 and 3). 
Sequence information
Length: 848 AA [This is the length of the unprocessed precursor] Molecular weight: 97586 Da [This is the MW of the unprocessed precursor] CRC64: F0400E3406B15018 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MYLYIETLKQ RLDAINQLRV DRALAAMGPA FQQVYSLLPT LLHYHHPLMP GYLDGNVPKG 

        70         80         90        100        110        120 
ICLYTPDETQ RHYLNELELY RGMSVQDPPK GELPITGVYT MGSTSSVGQS CSSDLDIWVC 

       130        140        150        160        170        180 
HQSWLDSEER QLLQRKCSLL ENWAASLGVE VSFFLIDENR FRHNESGSLG GEDCGSTQHI 

       190        200        210        220        230        240 
LLLDEFYRTA VRLAGKRILW NMVPCDEEEH YDDYVMTLYA QGVLTPNEWL DLGGLSSLSA 

       250        260        270        280        290        300 
EEYFGASLWQ LYKSIDSPYK AVLKTLLLEA YSWEYPNPRL LAKDIKQRLH DGEIVSFGLD 

       310        320        330        340        350        360 
PYCMMLERVT EYLTAIEDFT RLDLVRRCFY LKVCEKLSRE RACVGWRRAV LSQLVSEWGW 

       370        380        390        400        410        420 
DEARLAMLDN RANWKIDQVR EAHNELLDAM MQSYRNLIRF ARRNNLSVSA SPQDIGVLTR 

       430        440        450        460        470        480 
KLYAAFEALP GKVTLVNPQI SPDLSEPNLT FIYVPPGRAN RSGWYLYNRA PNIESIISHQ 

       490        500        510        520        530        540 
PLEYNRYLNK LVAWAWFNGL LTSRTRLYIK GNGIVDLPKL QEMVADVSHH FPLRLPAPTP 

       550        560        570        580        590        600 
KALYSPCEIR HLAIIVNLEY DPTAAFRNQV VHFDFRKLDV FSFGENQNCL VGSVDLLYRN 

       610        620        630        640        650        660 
SWNEVRTLHF NGEQSMIEAL KTILGKMHQD AAPPDSVEVF CYSQHLRGLI RTRVQQLVSE 

       670        680        690        700        710        720 
CIELRLSSTR QETGRFKALR VSGQTWGLFF ERLNVSVQKL ENAIEFYGAI SHNKLHGLSV 

       730        740        750        760        770        780 
QVETNHVKLP AVVDGFASEG IIQFFFEETQ DENGFNIYIL DESNRVEVYH HCEGSKEELV 

       790        800        810        820        830        840 
RDVSRFYSSS HDRFTYGSSF INFNLPQFYQ IVKVDGREQV IPFRTKSIGN MPPANQDHDT 


PLLQQYFS 

P00936 in FASTA format

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