[1]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1093/nar/15.11.4687; PubMed=3108857 [NCBI, ExPASy, EBI, Israel, Japan] Montgomery J.C., Venta P.J., Tashian R.E., Hewett-Emmett D.; "Nucleotide sequence of human liver carbonic anhydrase II cDNA."; Nucleic Acids Res. 15:4687-4687(1987).
[2]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1016/0888-7543(87)90008-5; PubMed=3121496 [NCBI, ExPASy, EBI, Israel, Japan] Murakami H., Marelich G.P., Grubb J.H., Kyle J.W., Sly W.S.; "Cloning, expression, and sequence homologies of cDNA for human carbonic anhydrase II."; Genomics 1:159-166(1987).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.; "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."; Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[4]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Ovary; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[5]	PROTEIN SEQUENCE OF 2-260. PubMed=4207120 [NCBI, ExPASy, EBI, Israel, Japan] Lin K.-T.D., Deutsch H.F.; "Human carbonic anhydrases. XII. The complete primary structure of the C isozyme."; J. Biol. Chem. 249:2329-2337(1974).
[6]	PROTEIN SEQUENCE OF 2-260. PubMed=823150 [NCBI, ExPASy, EBI, Israel, Japan] Henderson L.E., Henriksson D., Nyman P.O.; "Primary structure of human carbonic anhydrase C."; J. Biol. Chem. 251:5457-5463(1976).
[7]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-77. DOI=10.1016/0167-4781(85)90006-5; PubMed=3000449 [NCBI, ExPASy, EBI, Israel, Japan] Venta P.J., Montgomery J.C., Hewett-Emmett D., Tashian R.E.; "Comparison of the 5' regions of human and mouse carbonic anhydrase II genes and identification of possible regulatory elements."; Biochim. Biophys. Acta 826:195-201(1985).
[8]	INTERACTION WITH SLC4A4. DOI=10.1021/bi0353124; PubMed=14567693 [NCBI, ExPASy, EBI, Israel, Japan] Alvarez B.V., Loiselle F.B., Supuran C.T., Schwartz G.J., Casey J.R.; "Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter."; Biochemistry 42:12321-12329(2003).
[9]	INTERACTION WITH SLC4A7. DOI=10.1152/ajpcell.00382.2003; PubMed=14736710 [NCBI, ExPASy, EBI, Israel, Japan] Loiselle F.B., Morgan P.E., Alvarez B.V., Casey J.R.; "Regulation of the human NBC3 Na+/HCO3- cotransporter by carbonic anhydrase II and PKA."; Am. J. Physiol. 286:C1423-C1433(2004).
[10]	INTERACTION WITH SLC4A4. DOI=10.1113/jphysiol.2004.065110; PubMed=15218065 [NCBI, ExPASy, EBI, Israel, Japan] Pushkin A., Abuladze N., Gross E., Newman D., Tatishchev S., Lee I., Fedotoff O., Bondar G., Azimov R., Ngyuen M., Kurtz I.; "Molecular mechanism of kNBC1-carbonic anhydrase II interaction in proximal tubule cells."; J. Physiol. (Lond.) 559:55-65(2004).
[11]	X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS). PubMed=4621826 [NCBI, ExPASy, EBI, Israel, Japan] Liljas A., Kannan K.K., Bergsten P.-C., Waara I., Fridborg K., Strandberg B., Carlbom U., Jaerup L., Loevgren S., Petef M.; "Crystal structure of human carbonic anhydrase C."; Nature New Biol. 235:131-137(1972).
[12]	X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS). DOI=10.1002/prot.340040406; PubMed=3151019 [NCBI, ExPASy, EBI, Israel, Japan] Eriksson A.E., Jones T.A., Liljas A.; "Refined structure of human carbonic anhydrase II at 2.0-A resolution."; Proteins 4:274-282(1988).
[13]	X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS). DOI=10.1002/prot.340040407; PubMed=3151020 [NCBI, ExPASy, EBI, Israel, Japan] Eriksson A.E., Kylsten P.M., Jones T.A., Liljas A.; "Crystallographic studies of inhibitor binding sites in human carbonic anhydrase II: a pentacoordinated binding of the SCN-ion to the zinc at high pH."; Proteins 4:283-293(1988).
[14]	X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS). PubMed=9541386 [NCBI, ExPASy, EBI, Israel, Japan] Stams T., Chen Y., Boriack-Sjodin P.A., Hurt J.D., Liao J., May J.A., Dean T., Laipis P., Silverman D.N., Christianson D.W.; "Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination."; Protein Sci. 7:556-563(1998).
[15]	X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS). DOI=10.1021/bi001649j; PubMed=11076507 [NCBI, ExPASy, EBI, Israel, Japan] Cox J.D., Hunt J.A., Compher K.M., Fierke C.A., Christianson D.W.; "Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II."; Biochemistry 39:13687-13694(2000).
[16]	VARIANT JOGJAKARTA GLU-18. DOI=10.1007/BF00484072; PubMed=6817747 [NCBI, ExPASy, EBI, Israel, Japan] Jones G.L., Sofro A.S.M., Shaw D.C.; "Chemical and enzymological characterization of an Indonesian variant of human erythrocyte carbonic anhydrase II, CAII Jogjakarta (17 Lys leads to Glu)."; Biochem. Genet. 20:979-1000(1982).
[17]	VARIANT MELBOURNE HIS-236. DOI=10.1007/BF00274768; PubMed=6407977 [NCBI, ExPASy, EBI, Israel, Japan] Jones G.L., Shaw D.C.; "A chemical and enzymological comparison of the common major human erythrocyte carbonic anhydrase II, its minor component, and a new genetic variant, CA II Melbourne (237 Pro leads to His)."; Hum. Genet. 63:392-399(1983).
[18]	VARIANT OPTB3 TYR-107. PubMed=1928091 [NCBI, ExPASy, EBI, Israel, Japan] Venta P.J., Welty R.J., Johnson T.M., Sly W.S., Tashian R.E.; "Carbonic anhydrase II deficiency syndrome in a Belgian family is caused by a point mutation at an invariant histidine residue (107 His-->Tyr): complete structure of the normal human CA II gene."; Am. J. Hum. Genet. 49:1082-1090(1991).
[19]	VARIANT OPTB3 TYR-107. PubMed=1542674 [NCBI, ExPASy, EBI, Israel, Japan] Roth D.E., Venta P.J., Tashian R.E., Sly W.S.; "Molecular basis of human carbonic anhydrase II deficiency."; Proc. Natl. Acad. Sci. U.S.A. 89:1804-1808(1992).
[20]	VARIANT OPTB3 TYR-107. DOI=10.1007/s004390050068; PubMed=8834238 [NCBI, ExPASy, EBI, Israel, Japan] Soda H., Yukizane S., Yoshida I., Koga Y., Aramaki S., Kato H.; "A point mutation in exon 3 (His 107-->Tyr) in two unrelated Japanese patients with carbonic anhydrase II deficiency with central nervous system involvement."; Hum. Genet. 97:435-437(1996).
[21]	VARIANT OPTB3 PRO-92. DOI=10.1002/(SICI)1098-1004(1997)9:5<383::AID-HUMU1>3.3.CO;2-K; PubMed=9143915 [NCBI, ExPASy, EBI, Israel, Japan] Hu P.Y., Lim E.J., Ciccolella J., Strisciuglio P., Sly W.S.; "Seven novel mutations in carbonic anhydrase II deficiency syndrome identified by SSCP and direct sequencing analysis."; Hum. Mutat. 9:383-387(1997).
[22]	VARIANTS OPTB3 PRO-92; TYR-94; TYR-107 AND ARG-144, AND CHARACTERIZATION OF VARIANTS TYR-94 AND ARG-144. DOI=10.1002/humu.9266; PubMed=15300855 [NCBI, ExPASy, EBI, Israel, Japan] Shah G.N., Bonapace G., Hu P.Y., Strisciuglio P., Sly W.S.; "Carbonic anhydrase II deficiency syndrome (osteopetrosis with renal tubular acidosis and brain calcification): novel mutations in CA2 identified by direct sequencing expand the opportunity for genotype-phenotype correlation."; Hum. Mutat. 24:272-272(2004).

Comments

FUNCTION: Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide.
CATALYTIC ACTIVITY: H₂CO₃ = CO₂ + H₂O.
COFACTOR: Zinc.
SUBUNIT: Interacts with SLC4A4. Interaction with SLC4A7 regulates SLC4A7 transporter activity.
SUBCELLULAR LOCATION: Cytoplasm.
DISEASE: Defects in CA2 are the cause of autosomal recessive osteopetrosis type 3 (OPTB3) [MIM:259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.
SIMILARITY: Belongs to the alpha-carbonic anhydrase family.
WEB RESOURCE: Name=GeneReviews; URL="http://www.genetests.org/query?gene=CA2";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M77181; AAA51909.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M77176; AAA51909.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M77177; AAA51909.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M77178; AAA51909.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M77179; AAA51909.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M77180; AAA51909.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
Y00339; CAA68426.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X03251; CAA27012.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
J03037; AAA51908.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
CR536526; CAG38763.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
CR541875; CAG46673.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC011949; AAH11949.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M36532; AAA51911.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

A27175; CRHU2.

NP_000058.1; -.

3D structure databases

PDB

12CA; X-ray; 2.40 A; A=1-260.	[ExPASy / RCSB / EBI]
1A42; X-ray; 2.25 A; A=1-260.	[ExPASy / RCSB / EBI]
1AM6; X-ray; 2.00 A; A=1-260.	[ExPASy / RCSB / EBI]
1AVN; X-ray; 2.00 A; A=1-260.	[ExPASy / RCSB / EBI]
1BCD; X-ray; 1.90 A; A=1-260.	[ExPASy / RCSB / EBI]
1BIC; X-ray; 1.90 A; A=1-260.	[ExPASy / RCSB / EBI]
1BN1; X-ray; 2.10 A; A=1-260.	[ExPASy / RCSB / EBI]
1BN3; X-ray; 2.20 A; A=1-260.	[ExPASy / RCSB / EBI]
1BN4; X-ray; 2.10 A; A=1-260.	[ExPASy / RCSB / EBI]
1BNM; X-ray; 2.60 A; A=1-260.	[ExPASy / RCSB / EBI]
1BNN; X-ray; 2.30 A; A=1-260.	[ExPASy / RCSB / EBI]
1BNQ; X-ray; 2.40 A; A=1-260.	[ExPASy / RCSB / EBI]
1BNT; X-ray; 2.15 A; A=1-260.	[ExPASy / RCSB / EBI]
1BNU; X-ray; 2.15 A; A=1-260.	[ExPASy / RCSB / EBI]
1BNV; X-ray; 2.40 A; A=1-260.	[ExPASy / RCSB / EBI]
1BNW; X-ray; 2.25 A; A=1-260.	[ExPASy / RCSB / EBI]
1BV3; X-ray; 1.85 A; A=1-260.	[ExPASy / RCSB / EBI]
1CA2; X-ray; 2.00 A; A=1-260.	[ExPASy / RCSB / EBI]
1CA3; X-ray; 2.30 A; A=1-260.	[ExPASy / RCSB / EBI]
1CAH; X-ray; 1.88 A; A=1-260.	[ExPASy / RCSB / EBI]
1CAI; X-ray; 1.80 A; A=1-260.	[ExPASy / RCSB / EBI]
1CAJ; X-ray; 1.90 A; A=1-260.	[ExPASy / RCSB / EBI]
1CAK; X-ray; 1.90 A; A=1-260.	[ExPASy / RCSB / EBI]
1CAL; X-ray; 2.20 A; A=1-260.	[ExPASy / RCSB / EBI]
1CAM; X-ray; 1.70 A; A=1-260.	[ExPASy / RCSB / EBI]
1CAN; X-ray; 1.90 A; A=1-260.	[ExPASy / RCSB / EBI]
1CAO; X-ray; 1.90 A; A=1-260.	[ExPASy / RCSB / EBI]
1CAY; X-ray; 2.10 A; A=1-260.	[ExPASy / RCSB / EBI]
1CAZ; X-ray; 1.90 A; A=1-260.	[ExPASy / RCSB / EBI]
1CCS; X-ray; 2.35 A; A=1-260.	[ExPASy / RCSB / EBI]
1CCT; X-ray; 2.20 A; A=1-260.	[ExPASy / RCSB / EBI]
1CCU; X-ray; 2.25 A; A=1-260.	[ExPASy / RCSB / EBI]
1CIL; X-ray; 1.60 A; A=1-260.	[ExPASy / RCSB / EBI]
1CIM; X-ray; 2.10 A; A=1-260.	[ExPASy / RCSB / EBI]
1CIN; X-ray; 2.10 A; A=1-260.	[ExPASy / RCSB / EBI]
1CNB; X-ray; 2.35 A; A=1-260.	[ExPASy / RCSB / EBI]
1CNC; X-ray; 2.20 A; A=1-260.	[ExPASy / RCSB / EBI]
1CNG; X-ray; 1.90 A; A=1-260.	[ExPASy / RCSB / EBI]
1CNH; X-ray; 2.05 A; A=1-260.	[ExPASy / RCSB / EBI]
1CNI; X-ray; 1.80 A; A=1-260.	[ExPASy / RCSB / EBI]
1CNJ; X-ray; 1.80 A; A=1-260.	[ExPASy / RCSB / EBI]
1CNK; X-ray; 2.15 A; A=1-260.	[ExPASy / RCSB / EBI]
1CNW; X-ray; 2.00 A; A=1-260.	[ExPASy / RCSB / EBI]
1CNX; X-ray; 1.90 A; A=1-260.	[ExPASy / RCSB / EBI]
1CNY; X-ray; 2.30 A; A=1-260.	[ExPASy / RCSB / EBI]
1CRA; X-ray; 1.90 A; A=1-260.	[ExPASy / RCSB / EBI]
1CVA; X-ray; 2.25 A; A=1-260.	[ExPASy / RCSB / EBI]
1CVB; X-ray; 2.40 A; A=1-260.	[ExPASy / RCSB / EBI]
1CVC; X-ray; 2.30 A; A=1-260.	[ExPASy / RCSB / EBI]
1CVD; X-ray; 2.20 A; A=5-259.	[ExPASy / RCSB / EBI]
1CVE; X-ray; 2.25 A; A=1-260.	[ExPASy / RCSB / EBI]
1CVF; X-ray; 2.25 A; A=1-260.	[ExPASy / RCSB / EBI]
1CVH; X-ray; 2.30 A; A=5-259.	[ExPASy / RCSB / EBI]
1DCA; X-ray; 2.20 A; A=1-260.	[ExPASy / RCSB / EBI]
1DCB; X-ray; 2.10 A; A=1-260.	[ExPASy / RCSB / EBI]
1EOU; X-ray; 2.10 A; A=1-260.	[ExPASy / RCSB / EBI]
1F2W; X-ray; 1.90 A; A=1-260.	[ExPASy / RCSB / EBI]
1FQL; X-ray; 2.00 A; A=1-260.	[ExPASy / RCSB / EBI]
1FQM; X-ray; 2.00 A; A=1-260.	[ExPASy / RCSB / EBI]
1FQN; X-ray; 2.00 A; A=1-260.	[ExPASy / RCSB / EBI]
1FQR; X-ray; 2.00 A; A=1-260.	[ExPASy / RCSB / EBI]
1FR4; X-ray; 1.60 A; A=1-260.	[ExPASy / RCSB / EBI]
1FR7; X-ray; 1.50 A; A/B=1-260.	[ExPASy / RCSB / EBI]
1FSN; X-ray; 2.00 A; A/B=1-260.	[ExPASy / RCSB / EBI]
1FSQ; X-ray; 2.00 A; A/B=1-260.	[ExPASy / RCSB / EBI]
1FSR; X-ray; 2.00 A; A/B=1-260.	[ExPASy / RCSB / EBI]
1G0E; X-ray; 1.60 A; A=1-260.	[ExPASy / RCSB / EBI]
1G0F; X-ray; 1.60 A; A=1-260.	[ExPASy / RCSB / EBI]
1G1D; X-ray; 2.04 A; A=1-260.	[ExPASy / RCSB / EBI]
1G3Z; X-ray; 1.86 A; A=1-260.	[ExPASy / RCSB / EBI]
1G45; X-ray; 1.83 A; A=1-260.	[ExPASy / RCSB / EBI]
1G46; X-ray; 1.84 A; A=1-260.	[ExPASy / RCSB / EBI]
1G48; X-ray; 1.86 A; A=1-260.	[ExPASy / RCSB / EBI]
1G4J; X-ray; 1.84 A; A=1-260.	[ExPASy / RCSB / EBI]
1G4O; X-ray; 1.96 A; A=1-260.	[ExPASy / RCSB / EBI]
1G52; X-ray; 1.80 A; A=1-260.	[ExPASy / RCSB / EBI]
1G53; X-ray; 1.94 A; A=1-260.	[ExPASy / RCSB / EBI]
1G54; X-ray; 1.86 A; A=1-260.	[ExPASy / RCSB / EBI]
1H4N; X-ray; 2.00 A; A=1-260.	[ExPASy / RCSB / EBI]
1H9N; X-ray; 1.85 A; A=1-260.	[ExPASy / RCSB / EBI]
1H9Q; X-ray; 2.20 A; A=1-260.	[ExPASy / RCSB / EBI]
1HCA; X-ray; 2.30 A; A=1-260.	[ExPASy / RCSB / EBI]
1HEA; X-ray; 2.00 A; A=1-260.	[ExPASy / RCSB / EBI]
1HEB; X-ray; 2.00 A; A=1-260.	[ExPASy / RCSB / EBI]
1HEC; X-ray; 2.00 A; A=1-260.	[ExPASy / RCSB / EBI]
1HED; X-ray; 2.00 A; A=1-260.	[ExPASy / RCSB / EBI]
1HVA; X-ray; 2.30 A; A=1-260.	[ExPASy / RCSB / EBI]
1I8Z; X-ray; 1.93 A; A=1-260.	[ExPASy / RCSB / EBI]
1I90; X-ray; 2.00 A; A=1-260.	[ExPASy / RCSB / EBI]
1I91; X-ray; 2.00 A; A=1-260.	[ExPASy / RCSB / EBI]
1I9L; X-ray; 1.93 A; A=1-260.	[ExPASy / RCSB / EBI]
1I9M; X-ray; 1.84 A; A=1-260.	[ExPASy / RCSB / EBI]
1I9N; X-ray; 1.86 A; A=1-260.	[ExPASy / RCSB / EBI]
1I9O; X-ray; 1.86 A; A=1-260.	[ExPASy / RCSB / EBI]
1I9P; X-ray; 1.92 A; A=1-260.	[ExPASy / RCSB / EBI]
1I9Q; X-ray; 1.80 A; A=1-260.	[ExPASy / RCSB / EBI]
1IF4; X-ray; 1.93 A; A=1-260.	[ExPASy / RCSB / EBI]
1IF5; X-ray; 2.00 A; A=1-260.	[ExPASy / RCSB / EBI]
1IF6; X-ray; 2.09 A; A=1-260.	[ExPASy / RCSB / EBI]
1IF7; X-ray; 1.98 A; A=1-260.	[ExPASy / RCSB / EBI]
1IF8; X-ray; 1.94 A; A=1-260.	[ExPASy / RCSB / EBI]
1IF9; X-ray; 2.00 A; A=1-260.	[ExPASy / RCSB / EBI]
1KWQ; X-ray; 2.60 A; A=1-260.	[ExPASy / RCSB / EBI]
1KWR; X-ray; 2.25 A; A=1-260.	[ExPASy / RCSB / EBI]
1LG5; X-ray; 1.75 A; A=1-260.	[ExPASy / RCSB / EBI]
1LG6; X-ray; 2.20 A; A=1-260.	[ExPASy / RCSB / EBI]
1LGD; X-ray; 1.90 A; A=1-260.	[ExPASy / RCSB / EBI]
1LUG; X-ray; 0.95 A; A=2-260.	[ExPASy / RCSB / EBI]
1LZV; X-ray; 2.30 A; A=1-260.	[ExPASy / RCSB / EBI]
1MOO; X-ray; 1.05 A; A=1-260.	[ExPASy / RCSB / EBI]
1MUA; X-ray; 1.70 A; A=4-259.	[ExPASy / RCSB / EBI]
1OKL; X-ray; 2.10 A; A=1-260.	[ExPASy / RCSB / EBI]
1OKM; X-ray; 2.20 A; A=1-260.	[ExPASy / RCSB / EBI]
1OKN; X-ray; 2.40 A; A=1-260.	[ExPASy / RCSB / EBI]
1OQ5; X-ray; 1.50 A; A=1-260.	[ExPASy / RCSB / EBI]
1RAY; X-ray; 1.80 A; A=1-260.	[ExPASy / RCSB / EBI]
1RAZ; X-ray; 1.90 A; A=1-260.	[ExPASy / RCSB / EBI]
1RZA; X-ray; 1.90 A; A=1-260.	[ExPASy / RCSB / EBI]
1RZB; X-ray; 1.80 A; A=1-260.	[ExPASy / RCSB / EBI]
1RZC; X-ray; 1.90 A; A=1-260.	[ExPASy / RCSB / EBI]
1RZD; X-ray; 1.90 A; A=1-260.	[ExPASy / RCSB / EBI]
1RZE; X-ray; 1.90 A; A=1-260.	[ExPASy / RCSB / EBI]
1T9N; X-ray; 2.00 A; A=1-260.	[ExPASy / RCSB / EBI]
1TB0; X-ray; 2.00 A; X=1-260.	[ExPASy / RCSB / EBI]
1TBT; X-ray; 2.00 A; X=1-260.	[ExPASy / RCSB / EBI]
1TE3; X-ray; 2.00 A; X=1-260.	[ExPASy / RCSB / EBI]
1TEQ; X-ray; 2.00 A; X=1-260.	[ExPASy / RCSB / EBI]
1TEU; X-ray; 2.00 A; X=1-260.	[ExPASy / RCSB / EBI]
1TG3; X-ray; 1.80 A; A=1-260.	[ExPASy / RCSB / EBI]
1TG9; X-ray; 1.90 A; A=1-260.	[ExPASy / RCSB / EBI]
1TH9; X-ray; 1.63 A; A=1-260.	[ExPASy / RCSB / EBI]
1THK; X-ray; 1.80 A; A=1-260.	[ExPASy / RCSB / EBI]
1TTM; X-ray; 1.95 A; A=1-260.	[ExPASy / RCSB / EBI]
1UGA; X-ray; 2.00 A; A=3-260.	[ExPASy / RCSB / EBI]
1UGB; X-ray; 2.00 A; A=3-260.	[ExPASy / RCSB / EBI]
1UGC; X-ray; 2.00 A; A=3-260.	[ExPASy / RCSB / EBI]
1UGD; X-ray; 2.00 A; A=3-260.	[ExPASy / RCSB / EBI]
1UGE; X-ray; 1.90 A; A=3-260.	[ExPASy / RCSB / EBI]
1UGF; X-ray; 2.00 A; A=3-260.	[ExPASy / RCSB / EBI]
1UGG; X-ray; 2.20 A; A=3-260.	[ExPASy / RCSB / EBI]
1XEG; X-ray; 1.81 A; A=1-260.	[ExPASy / RCSB / EBI]
1XEV; X-ray; 2.20 A; A/B/C/D=1-260.	[ExPASy / RCSB / EBI]
1XPZ; X-ray; 2.02 A; A=3-260.	[ExPASy / RCSB / EBI]
1XQ0; X-ray; 1.76 A; A=1-260.	[ExPASy / RCSB / EBI]
1YDA; X-ray; 2.10 A; A=1-260.	[ExPASy / RCSB / EBI]
1YDB; X-ray; 1.90 A; A=1-260.	[ExPASy / RCSB / EBI]
1YDC; X-ray; 1.95 A; A=1-260.	[ExPASy / RCSB / EBI]
1YDD; X-ray; 2.10 A; A=1-260.	[ExPASy / RCSB / EBI]
1YO0; X-ray; 1.80 A; A=1-260.	[ExPASy / RCSB / EBI]
1YO1; X-ray; 1.70 A; A=1-260.	[ExPASy / RCSB / EBI]
1YO2; X-ray; 1.80 A; A=1-260.	[ExPASy / RCSB / EBI]
1Z9Y; X-ray; 1.66 A; A=1-260.	[ExPASy / RCSB / EBI]
1ZE8; X-ray; 2.00 A; A=1-260.	[ExPASy / RCSB / EBI]
1ZFK; X-ray; 1.56 A; A=1-260.	[ExPASy / RCSB / EBI]
1ZFQ; X-ray; 1.55 A; A=1-260.	[ExPASy / RCSB / EBI]
1ZGE; X-ray; 1.65 A; A=1-260.	[ExPASy / RCSB / EBI]
1ZGF; X-ray; 1.75 A; A=1-260.	[ExPASy / RCSB / EBI]
1ZH9; X-ray; 1.70 A; A=1-260.	[ExPASy / RCSB / EBI]
1ZSA; X-ray; 2.50 A; A=1-260.	[ExPASy / RCSB / EBI]
1ZSB; X-ray; 2.00 A; A=1-260.	[ExPASy / RCSB / EBI]
1ZSC; X-ray; 1.80 A; A=1-260.	[ExPASy / RCSB / EBI]
2ABE; X-ray; 2.00 A; A=1-260.	[ExPASy / RCSB / EBI]
2AW1; X-ray; 1.46 A; A=2-260.	[ExPASy / RCSB / EBI]
2AX2; X-ray; 1.50 A; A=1-260.	[ExPASy / RCSB / EBI]
2CA2; X-ray; 1.90 A; A=1-260.	[ExPASy / RCSB / EBI]
2CBA; X-ray; 1.54 A; A=1-260.	[ExPASy / RCSB / EBI]
2CBB; X-ray; 1.67 A; A=1-260.	[ExPASy / RCSB / EBI]
2CBC; X-ray; 1.88 A; A=1-260.	[ExPASy / RCSB / EBI]
2CBD; X-ray; 1.67 A; A=1-260.	[ExPASy / RCSB / EBI]
2CBE; X-ray; 1.82 A; A=1-260.	[ExPASy / RCSB / EBI]
2EU2; X-ray; 1.15 A; A=1-260.	[ExPASy / RCSB / EBI]
2EU3; X-ray; 1.60 A; A=1-260.	[ExPASy / RCSB / EBI]
2EZ7; X-ray; 2.00 A; A=1-260.	[ExPASy / RCSB / EBI]
2F14; X-ray; 1.71 A; A=1-260.	[ExPASy / RCSB / EBI]
2FMG; X-ray; 1.60 A; A=1-260.	[ExPASy / RCSB / EBI]
2FMZ; X-ray; 1.60 A; A=1-260.	[ExPASy / RCSB / EBI]
2FNK; X-ray; 1.80 A; A=1-260.	[ExPASy / RCSB / EBI]
2FNM; X-ray; 1.80 A; A=1-260.	[ExPASy / RCSB / EBI]
2FNN; X-ray; 1.80 A; A=1-260.	[ExPASy / RCSB / EBI]
2FOQ; X-ray; 1.25 A; A=1-260.	[ExPASy / RCSB / EBI]
2FOS; X-ray; 1.10 A; A=1-260.	[ExPASy / RCSB / EBI]
2FOU; X-ray; 0.99 A; A=1-260.	[ExPASy / RCSB / EBI]
2FOV; X-ray; 1.15 A; A=1-260.	[ExPASy / RCSB / EBI]
2GD8; X-ray; 1.46 A; A=2-260.	[ExPASy / RCSB / EBI]
2GEH; X-ray; 2.00 A; A=1-260.	[ExPASy / RCSB / EBI]
2H15; X-ray; 1.90 A; A=1-260.	[ExPASy / RCSB / EBI]
2H4N; X-ray; 1.90 A; A=1-260.	[ExPASy / RCSB / EBI]
2HD6; X-ray; 1.80 A; A=2-260.	[ExPASy / RCSB / EBI]
2HKK; X-ray; 1.90 A; A=1-260.	[ExPASy / RCSB / EBI]
2HL4; X-ray; 1.55 A; A=2-260.	[ExPASy / RCSB / EBI]
2HNC; X-ray; 1.55 A; A=2-260.	[ExPASy / RCSB / EBI]
2HOC; X-ray; 2.10 A; A=1-260.	[ExPASy / RCSB / EBI]
2ILI; X-ray; 1.05 A; A=2-260.	[ExPASy / RCSB / EBI]
2NNG; X-ray; 1.20 A; A=1-260.	[ExPASy / RCSB / EBI]
2NNO; X-ray; 1.01 A; A=1-260.	[ExPASy / RCSB / EBI]
2NNS; X-ray; 1.03 A; A=1-260.	[ExPASy / RCSB / EBI]
2NNV; X-ray; 1.10 A; A=1-260.	[ExPASy / RCSB / EBI]
2NWO; X-ray; 1.70 A; A=1-260.	[ExPASy / RCSB / EBI]
2NWP; X-ray; 1.80 A; A=1-260.	[ExPASy / RCSB / EBI]
2NWY; X-ray; 1.65 A; A=1-260.	[ExPASy / RCSB / EBI]
2NWZ; X-ray; 1.80 A; A=1-260.	[ExPASy / RCSB / EBI]
2NXR; X-ray; 1.70 A; A=1-260.	[ExPASy / RCSB / EBI]
2NXS; X-ray; 1.80 A; A=1-260.	[ExPASy / RCSB / EBI]
2NXT; X-ray; 1.15 A; A=1-260.	[ExPASy / RCSB / EBI]
2O4Z; X-ray; 2.10 A; A=1-260.	[ExPASy / RCSB / EBI]
2OSF; X-ray; 1.60 A; A=2-260.	[ExPASy / RCSB / EBI]
2OSM; X-ray; 1.60 A; A=2-260.	[ExPASy / RCSB / EBI]
2POU; X-ray; 1.60 A; A=1-260.	[ExPASy / RCSB / EBI]
2POV; X-ray; 1.60 A; A=1-259.	[ExPASy / RCSB / EBI]
2POW; X-ray; 1.75 A; A=1-260.	[ExPASy / RCSB / EBI]
2Q1B; X-ray; 1.70 A; A=1-260.	[ExPASy / RCSB / EBI]
2Q38; X-ray; 1.95 A; A=1-260.	[ExPASy / RCSB / EBI]
2QO8; X-ray; 1.40 A; A=2-260.	[ExPASy / RCSB / EBI]
2QOA; X-ray; 1.60 A; A=2-260.	[ExPASy / RCSB / EBI]
2QP6; X-ray; 1.45 A; A=2-260.	[ExPASy / RCSB / EBI]
3B4F; X-ray; 1.89 A; A=1-260.	[ExPASy / RCSB / EBI]
3BL0; X-ray; 1.90 A; A=1-260.	[ExPASy / RCSB / EBI]
3BL1; X-ray; 2.10 A; A=1-260.	[ExPASy / RCSB / EBI]
3CA2; X-ray; 2.00 A; A=1-260.	[ExPASy / RCSB / EBI]
3CAJ; X-ray; 1.80 A; A=1-260.	[ExPASy / RCSB / EBI]
3CYU; X-ray; 1.70 A; A=1-260.	[ExPASy / RCSB / EBI]
4CA2; X-ray; 2.10 A; A=1-260.	[ExPASy / RCSB / EBI]
4CAC; X-ray; 2.20 A; A=1-260.	[ExPASy / RCSB / EBI]
5CA2; X-ray; 2.10 A; A=1-260.	[ExPASy / RCSB / EBI]
5CAC; X-ray; 2.20 A; A=1-260.	[ExPASy / RCSB / EBI]
6CA2; X-ray; 2.50 A; A=1-260.	[ExPASy / RCSB / EBI]
7CA2; X-ray; 2.40 A; A=1-260.	[ExPASy / RCSB / EBI]
8CA2; X-ray; 2.40 A; A=1-260.	[ExPASy / RCSB / EBI]
9CA2; X-ray; 2.80 A; A=1-260.	[ExPASy / RCSB / EBI]