[1]	PROTEIN SEQUENCE, AND DISULFIDE BONDS. STRAIN=ATCC 29487 / DSM 2043 / LMG 8762 / UASM 495 / VKM B-2235; Damaglou A.P., Allen L.C., Whitaker D.R.; Submitted (MAR-1974) to the PIR data bank.

Comments

CATALYTIC ACTIVITY: Cleavage of N-acetylmuramoyl-|-Ala, and of the insulin B chain at 23-Gly-|-Phe-24 > 18-Val-|-Cys(SO₃H).
COFACTOR: Binds 1 zinc ion per subunit.
SIMILARITY: Belongs to the peptidase M23A family [view classification].

Copyright

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Cross-references

Sequence databases

PIR

A00994; LYYXB4.

3D structure databases

ModBase

P00801.

Protein family/group databases

MEROPS

M23.001; -.

Ontologies

GO:0008270;	Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR000841; Pept_M23A_Blytic.
Graphical view of domain structure.

PRINTS

PR00933; BLYTICPTASE.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; Hydrolase; Metal-binding; Metalloprotease; Protease; Zinc.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 178`	`178`	`Beta-lytic metalloendopeptidase.`	`PRO_0000165903`
`METAL`	`120 120`		`Zinc (Potential).`
`METAL`	`122 122`		`Zinc (Potential).`
`DISULFID`	`65 111`
`DISULFID`	`155 168`

Sequence information

Length: 178 AA [This is the length of the unprocessed precursor]

Molecular weight: 19100 Da [This is the MW of the unprocessed precursor]

CRC64: 9EFCD3DD45FD2870 [This is a checksum on the sequence]

        10         20         30         40         50         60 
SPNGLLQFPF PRGASWHVGG AHTNTGSGNY PMSSLDMSRG GGSNQNGNWV SASAAGGSFK 

        70         80         90        100        110        120 
RHSSCFAEIV HTGGWSTTYY HLMNIQYNTG ANVSMNTAIA NAPNTQAQAL CNGGQSTGPH 

       130        140        150        160        170 
QHWSLKQNGS FYHLNGTYLS GYRITATGSS YDTNCSRFYL TKNGQNYCYG YYVNPGPN

P00801 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools