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UniProtKB/Swiss-Prot entry P00786


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CATH_RAT
Primary accession number P00786
Secondary accession numbers None
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on August 1, 1988 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 82)
Name and origin of the protein
Protein name Cathepsin H [Precursor]
Synonyms EC 3.4.22.16
Cathepsin B3
Cathepsin BA
Contains Cathepsin H mini chain
Cathepsin H heavy chain
Cathepsin H light chain
Gene name
Name: Ctsh
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Wistar;
TISSUE=Kidney;
DOI=10.1016/0014-5793(87)80545-8; PubMed=3691815 [NCBI, ExPASy, EBI, Israel, Japan]
Ishidoh K., Imajoh S., Emori Y., Ohno S., Kawasaki H., Minami Y., Kominami E., Katunuma N., Suzuki K.;
"Molecular cloning and sequencing of cDNA for rat cathepsin H. Homology in pro-peptide regions of cysteine proteinases.";
FEBS Lett. 226:33-37(1987).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
DOI=10.1016/0014-5793(89)80939-1; PubMed=2759235 [NCBI, ExPASy, EBI, Israel, Japan]
Ishidoh K., Kominami E., Katunuma N., Suzuki K.;
"Gene structure of rat cathepsin H.";
FEBS Lett. 253:103-107(1989).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 4-333.
TISSUE=Liver;
DOI=10.1016/0020-711X(90)90237-W; PubMed=2276418 [NCBI, ExPASy, EBI, Israel, Japan]
Qian F., Frankfater A., Miller R.V., Chan S.J., Steiner D.F.;
"Molecular cloning of rat precursor cathepsin H and the expression of five lysosomal cathepsins in normal tissues and in a rat carcinosarcoma.";
Int. J. Biochem. 22:1457-1464(1990).
[5]
PROTEIN SEQUENCE OF 114-333.
TISSUE=Liver;
PubMed=6574504 [NCBI, ExPASy, EBI, Israel, Japan]
Takio K., Towatari T., Katunuma N., Teller D.C., Titani K.;
"Homology of amino acid sequences of rat liver cathepsins B and H with that of papain.";
Proc. Natl. Acad. Sci. U.S.A. 80:3666-3670(1983).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Y00708; CAA68699.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC085352; AAH85352.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M38135; AAA63484.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S00211; KHRTH.
RefSeq NP_037071.1; -.
UniGene Rn.1997
3D structure databases
HSSP O46427; 8PCH. [HSSP ENTRY / PDB]
SMR P00786; 114-333.
ModBase P00786.
Protein family/group databases
MEROPS C01.040; -.
I29.003; -.
Organism-specific databases
RGD 2447; Ctsh.
Gene expression databases
ArrayExpress P00786; -.
GermOnline ENSRNOG00000014064; Rattus norvegicus.
Ontologies
GO
GO:0005764; Cellular component: lysosome (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000169; Pept_cys_AS.
IPR013128; Peptidase_C1A.
IPR000668; Peptidase_C1A_C.
IPR013201; Prot_inhib_I29.
Graphical view of domain structure.
PANTHER PTHR12411; Peptidase_C1A; 1.
Pfam PF08246; Inhibitor_I29; 1.
PF00112; Peptidase_C1; 1.
Pfam graphical view of domain structure.
PRINTS PR00705; PAPAIN.
ProDom PD000158; Peptidase_C1; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00645; Pept_C1; 1.
SMART graphical view of domain structure.
PROSITE PS00640; THIOL_PROTEASE_ASN; 1.
PS00139; THIOL_PROTEASE_CYS; 1.
PS00639; THIOL_PROTEASE_HIS; 1.
BLOCKS P00786.
ProtoNet P00786.
Genome annotation databases
Ensembl ENSRNOG00000014064; Rattus norvegicus. [Contig view]
GeneID 25425; -.
KEGG rno:25425; -.
Phylogenomic databases
HOVERGEN P00786; -.
Other
NextBio 606599; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Glycoprotein; Hydrolase; Lysosome; Protease; Signal; Thiol protease; Zymogen.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    20  20     Potential. 
PROPEP   21    95  75     Activation peptide. PRO_0000026224
CHAIN   96   103  8     Cathepsin H mini chain. PRO_0000026225
PROPEP   104   113  10     Potential. PRO_0000026226
CHAIN   114   333  220     Cathepsin H. PRO_0000026227
CHAIN   114   290  177     Cathepsin H heavy chain. PRO_0000026228
CHAIN   291   333  43     Cathepsin H light chain. PRO_0000026229
ACT_SITE   139   139        By similarity. 
ACT_SITE   279   279        By similarity. 
ACT_SITE   299   299        By similarity. 
CARBOHYD   228   228        N-linked (GlcNAc...). 
DISULFID   100   325        By similarity. 
DISULFID   136   179        By similarity. 
DISULFID   170   212        By similarity. 
DISULFID   270   320        By similarity. 
VARIANT   287   287  1     G -> A. 
Sequence information
Length: 333 AA [This is the length of the unprocessed precursor] Molecular weight: 37104 Da [This is the MW of the unprocessed precursor] CRC64: A90AC66338F0B744 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MWTALPLLCA GAWLLSAGAT AELTVNAIEK FHFTSWMKQH QKTYSSREYS HRLQVFANNW 

        70         80         90        100        110        120 
RKIQAHNQRN HTFKMGLNQF SDMSFAEIKH KYLWSEPQNC SATKSNYLRG TGPYPSSMDW 

       130        140        150        160        170        180 
RKKGNVVSPV KNQGACGSCW TFSTTGALES AVAIASGKMM TLAEQQLVDC AQNFNNHGCQ 

       190        200        210        220        230        240 
GGLPSQAFEY ILYNKGIMGE DSYPYIGKNG QCKFNPEKAV AFVKNVVNIT LNDEAAMVEA 

       250        260        270        280        290        300 
VALYNPVSFA FEVTEDFMMY KSGVYSSNSC HKTPDKVNHA VLAVGYGEQN GLLYWIVKNS 

       310        320        330 
WGSNWGNNGY FLIERGKNMC GLAACASYPI PQV 

P00786 in FASTA format

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