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UniProtKB/Swiss-Prot entry P00758


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name KLK1_RAT
Primary accession number P00758
Secondary accession number Q68G17
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on June 1, 1994 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 76)
Name and origin of the protein
Protein name Kallikrein-1 [Precursor]
Synonyms EC 3.4.21.35
Gamma-NGF
Tissue kallikrein
True tissue kallikrein
True kallikrein
PS kallikrein
RGK-1
rK-1
Pancreatic kallikrein
Nerve growth factor gamma chain
Contains Nerve growth factor gamma chain 1
Nerve growth factor gamma chain 2
Gene name
Name: Ngfg
Synonyms: Klk-1, Klk1
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Pancreas;
PubMed=6961406 [NCBI, ExPASy, EBI, Israel, Japan]
Swift G.H., Dagorn J.-C., Ashley P.L., Cummings S.W., MacDonald R.J.;
"Rat pancreatic kallikrein mRNA: nucleotide sequence and amino acid sequence of the encoded preproenzyme.";
Proc. Natl. Acad. Sci. U.S.A. 79:7263-7267(1982).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Submandibular gland;
DOI=10.1021/bi00338a005; PubMed=2998455 [NCBI, ExPASy, EBI, Israel, Japan]
Ashley P.L., MacDonald R.J.;
"Kallikrein-related mRNAs of the rat submaxillary gland: nucleotide sequences of four distinct types including tonin.";
Biochemistry 24:4512-4520(1985).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Kidney;
PubMed=2753879 [NCBI, ExPASy, EBI, Israel, Japan]
Inoue H., Fukui K., Miyake Y.;
"Identification and structure of the rat true tissue kallikrein gene expressed in the kidney.";
J. Biochem. 105:834-840(1989).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2708383 [NCBI, ExPASy, EBI, Israel, Japan]
Wines D.R., Brady J.M., Pritchett D.B., Roberts J.L., MacDonald R.J.;
"Organization and expression of the rat kallikrein gene family.";
J. Biol. Chem. 264:7653-7662(1989).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
NUCLEOTIDE SEQUENCE [MRNA] OF 48-261.
TISSUE=Submandibular gland;
DOI=10.1016/0167-4781(86)90093-X; PubMed=3004582 [NCBI, ExPASy, EBI, Israel, Japan]
Gerald W.L., Chao J., Chao L.;
"Immunological identification of rat tissue kallikrein cDNA and characterization of the kallikrein gene family.";
Biochim. Biophys. Acta 866:1-14(1986).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
J00758; -; NOT_ANNOTATED_CDS; mRNA.[EMBL / GenBank / DDBJ]
M11563; AAA41464.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D00448; BAA00346.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M23876; AAA41462.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M23874; AAA41462.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M23875; AAA41462.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC078784; AAH78784.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X03560; CAA27247.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A00944; KQRTP.
RefSeq NP_113711.1; -.
UniGene Rn.11331
3D structure databases
HSSP P00757; 1SGF. [HSSP ENTRY / PDB]
SMR P00758; 25-261.
ModBase P00758.
Protein family/group databases
MEROPS S01.405; -.
Organism-specific databases
RGD 3175; Ngfg.
Gene expression databases
ArrayExpress P00758; -.
GermOnline ENSRNOG00000029221; Rattus norvegicus.
Family and domain databases
InterPro IPR001254; Peptidase_S1_S6.
IPR001314; Peptidase_S1A.
Graphical view of domain structure.
Pfam PF00089; Trypsin; 1.
Pfam graphical view of domain structure.
PRINTS PR00722; CHYMOTRYPSIN.
SMART SM00020; Tryp_SPc; 1.
SMART graphical view of domain structure.
PROSITE PS50240; TRYPSIN_DOM; 1.
PS00134; TRYPSIN_HIS; 1.
PS00135; TRYPSIN_SER; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P00758.
ProtoNet P00758.
Genome annotation databases
Ensembl ENSRNOG00000029221; Rattus norvegicus. [Contig view]
GeneID 24594; -.
KEGG rno:24594; -.
Phylogenomic databases
HOVERGEN P00758; -.
Other
NextBio 603788; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Glycoprotein; Hydrolase; Protease; Serine protease; Signal; Zymogen.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    18  18     Probable. 
PROPEP   19    24  6     Activation peptide (Probable). PRO_0000027999
CHAIN   25   261  237     Kallikrein-1. PRO_0000028000
CHAIN   25   111  87     Nerve growth factor gamma chain 1. PRO_0000028001
CHAIN   112   261  150     Nerve growth factor gamma chain 2. PRO_0000028002
DOMAIN   25   258  234     Peptidase S1. 
ACT_SITE   65    65        Charge relay system. 
ACT_SITE   120   120        Charge relay system. 
ACT_SITE   213   213        Charge relay system. 
CARBOHYD   108   108        N-linked (GlcNAc...) (Probable). 
DISULFID   31   173        By similarity. 
DISULFID   50    66        By similarity. 
DISULFID   152   219        By similarity. 
DISULFID   184   198        By similarity. 
DISULFID   209   234        By similarity. 
Sequence information
Length: 261 AA [This is the length of the unprocessed precursor] Molecular weight: 28852 Da [This is the MW of the unprocessed precursor] CRC64: F2F99C0227A7882B [This is a checksum on the sequence]
        10         20         30         40         50         60 
MWFLILFLAL SLGRNDAAPP VQSRVVGGYN CEMNSQPWQV AVYYFGEYLC GGVLIDPSWV 

        70         80         90        100        110        120 
ITAAHCATDN YQVWLGRNNL YEDEPFAQHR LVSQSFPHPG FNQDLIWNHT RQPGDDYSND 

       130        140        150        160        170        180 
LMLLHLSQPA DITDGVKVID LPIEEPKVGS TCLASGWGSI TPDGLELSDD LQCVNIDLLS 

       190        200        210        220        230        240 
NEKCVEAHKE EVTDLMLCAG EMDGGKDTCK GDSGGPLICN GVLQGITSWG FNPCGEPKKP 

       250        260 
GIYTKLIKFT PWIKEVMKEN P 

P00758 in FASTA format

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