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UniProtKB/Swiss-Prot entry P00755


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name K1KB1_MOUSE
Primary accession number P00755
Secondary accession numbers None
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on July 21, 1986 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 79)
Name and origin of the protein
Protein name Kallikrein 1-related peptidase b1 [Precursor]
Synonyms EC 3.4.21.35
Glandular kallikrein K1
mGK-1
Tissue kallikrein-1
Gene name
Name: Klk1b1
Synonyms: Klk-1, Klk1
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Quakenbush inbred;
DOI=10.1038/303300a0; PubMed=6602295 [NCBI, ExPASy, EBI, Israel, Japan]
Mason A.J., Evans B.A., Cox D.R., Shine J., Richards R.I.;
"Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides.";
Nature 303:300-307(1983).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3036794 [NCBI, ExPASy, EBI, Israel, Japan]
Evans B.A., Drinkwater C.C., Richards R.I.;
"Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus.";
J. Biol. Chem. 262:8027-8034(1987).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Salivary gland;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
V00829; CAA24213.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
J00390; AAA39349.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC026378; AAH26378.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A00941; KQMS1.
RefSeq NP_034775.1; -.
UniGene Mm.447819
3D structure databases
HSSP P00757; 1SGF. [HSSP ENTRY / PDB]
SMR P00755; 25-261.
ModBase P00755.
Protein family/group databases
MEROPS S01.164; -.
PTM databases
PhosphoSite P00755; -.
Organism-specific databases
MGI MGI:892019; Klk1b1.
Gene expression databases
ArrayExpress P00755; -.
CleanEx MM_KLK1; -.
MM_KLK1B1; -.
GermOnline ENSMUSG00000063133; Mus musculus.
Family and domain databases
InterPro IPR001254; Peptidase_S1_S6.
IPR001314; Peptidase_S1A.
Graphical view of domain structure.
Pfam PF00089; Trypsin; 1.
Pfam graphical view of domain structure.
PRINTS PR00722; CHYMOTRYPSIN.
SMART SM00020; Tryp_SPc; 1.
SMART graphical view of domain structure.
PROSITE PS50240; TRYPSIN_DOM; 1.
PS00134; TRYPSIN_HIS; 1.
PS00135; TRYPSIN_SER; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P00755.
ProtoNet P00755.
Genome annotation databases
Ensembl ENSMUSG00000063133; Mus musculus. [Contig view]
GeneID 16623; -.
KEGG mmu:16623; -.
Phylogenomic databases
HOVERGEN P00755; -.
Other
NextBio 290235; -.
SOURCE Klk1b1; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Glycoprotein; Hydrolase; Protease; Serine protease; Signal; Zymogen.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    18  18     Probable. 
PROPEP   19    24  6     Activation peptide (Probable). PRO_0000027966
CHAIN   25   261  237     Kallikrein 1-related peptidase b1. PRO_0000027967
DOMAIN   25   258  234     Peptidase S1. 
ACT_SITE   65    65        Charge relay system. 
ACT_SITE   120   120        Charge relay system. 
ACT_SITE   213   213        Charge relay system. 
CARBOHYD   102   102        N-linked (GlcNAc...) (Probable). 
DISULFID   31   173        By similarity. 
DISULFID   50    66        By similarity. 
DISULFID   152   219        By similarity. 
DISULFID   184   198        By similarity. 
DISULFID   209   234        By similarity. 
Sequence information
Length: 261 AA [This is the length of the unprocessed precursor] Molecular weight: 29022 Da [This is the MW of the unprocessed precursor] CRC64: 15DC946600AF1604 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MWFLILFLAL SLGGIDAAPP VQSRIVGGFK CEKNSQPWHV AVYRYKEYIC GGVLLDANWV 

        70         80         90        100        110        120 
LTAAHCYYEK NNVWLGKNNL YQDEPSAQHR LVSKSFLHPC YNMSLHRNRI QNPQDDYSYD 

       130        140        150        160        170        180 
LMLLRLSKPA DITDVVKPIA LPTEEPKLGS TCLASGWGSI IPVKFQYAKD LQCVNLKLLP 

       190        200        210        220        230        240 
NEDCDKAYVQ KVTDVMLCAG VKGGGKDTCK GDSGGPLICD GVLQGLTSWG YNPCGEPKKP 

       250        260 
GVYTKLIKFT SWIKDTLAQN P 

P00755 in FASTA format

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