[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Melanoma;
DOI=10.1038/301214a0; PubMed=6337343 [NCBI, ExPASy, EBI, Israel, Japan]
Pennica D.,
Holmes W.E.,
Kohr W.J.,
Harkins R.N.,
Vehar G.A.,
Ward C.A.,
Bennett W.F.,
Yelverton E.,
Seeburg P.H.,
Heyneker H.L.,
Goeddel D.V.,
Collen D.;
"Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli.";
Nature 301:214-221(1983).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=6089198 [NCBI, ExPASy, EBI, Israel, Japan]
Ny T.,
Elgh F.,
Lund B.;
"The structure of the human tissue-type plasminogen activator gene: correlation of intron and exon structures to functional and structural domains.";
Proc. Natl. Acad. Sci. U.S.A. 81:5355-5359(1984).
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[3]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3009482 [NCBI, ExPASy, EBI, Israel, Japan]
Friezner Degen S.J.,
Rajput B.,
Reich E.;
"The human tissue plasminogen activator gene.";
J. Biol. Chem. 261:6972-6985(1986).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=3090401 [NCBI, ExPASy, EBI, Israel, Japan]
Harris T.J.,
Patel T.,
Marston F.A.,
Little S.,
Emtage J.S.,
Opdenakker G.,
Volckaert G.,
Rombauts W.,
Billiau A.,
Somer P.;
"Cloning of cDNA coding for human tissue-type plasminogen activator and its expression in Escherichia coli.";
Mol. Biol. Med. 3:279-292(1986).
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[5]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=2824147 [NCBI, ExPASy, EBI, Israel, Japan]
Reddy V.B.,
Garramone A.J.,
Sasak H.,
Wei C.-M.,
Watkins P.,
Galli J.,
Hsiung N.;
"Expression of human uterine tissue-type plasminogen activator in mouse cells using BPV vectors.";
DNA 6:461-472(1987).
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[6]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Fetal lung;
DOI=10.1093/nar/16.12.5695; PubMed=3133640 [NCBI, ExPASy, EBI, Israel, Japan]
Sasaki H.,
Saito Y.,
Hayashi M.,
Otsuka K.,
Niwa M.;
"Nucleotide sequence of the tissue-type plasminogen activator cDNA from human fetal lung cells.";
Nucleic Acids Res. 16:5695-5695(1988).
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[7]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
TISSUE=Umbilical vein;
DOI=10.1093/nar/18.4.1086; PubMed=2107528 [NCBI, ExPASy, EBI, Israel, Japan]
Siebert P.D.,
Fong K.;
"Variant tissue-type plasminogen activator (PLAT) cDNA obtained from human endothelial cells.";
Nucleic Acids Res. 18:1086-1086(1990).
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[8]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
Dou D.;
"A brain-type plasminogen activator.";
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
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[9]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Liu Y.,
Xu L.,
Zeng Y.,
He X.;
"cDNA of tissue plasminogen activator.";
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
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[10]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T.,
Suzuki Y.,
Nishikawa T.,
Otsuki T.,
Sugiyama T.,
Irie R.,
Wakamatsu A.,
Hayashi K.,
Sato H.,
Nagai K.,
Kimura K.,
Makita H.,
Sekine M.,
Obayashi M.,
Nishi T.,
Shibahara T.,
Tanaka T.,
Ishii S.,
Yamamoto J., ![]()
Saito K.,
Kawai Y.,
Isono Y.,
Nakamura Y.,
Nagahari K.,
Murakami K.,
Yasuda T.,
Iwayanagi T.,
Wagatsuma M.,
Shiratori A.,
Sudo H.,
Hosoiri T.,
Kaku Y.,
Kodaira H.,
Kondo H.,
Sugawara M.,
Takahashi M.,
Kanda K.,
Yokoi T.,
Furuya T.,
Kikkawa E.,
Omura Y.,
Abe K.,
Kamihara K.,
Katsuta N.,
Sato K.,
Tanikawa M.,
Yamazaki M.,
Ninomiya K.,
Ishibashi T.,
Yamashita H.,
Murakawa K.,
Fujimori K.,
Tanai H.,
Kimata M.,
Watanabe M.,
Hiraoka S.,
Chiba Y.,
Ishida S.,
Ono Y.,
Takiguchi S.,
Watanabe S.,
Yosida M.,
Hotuta T.,
Kusano J.,
Kanehori K.,
Takahashi-Fujii A.,
Hara H.,
Tanase T.-O.,
Nomura Y.,
Togiya S.,
Komai F.,
Hara R.,
Takeuchi K.,
Arita M.,
Imose N.,
Musashino K.,
Yuuki H.,
Oshima A.,
Sasaki N.,
Aotsuka S.,
Yoshikawa Y.,
Matsunawa H.,
Ichihara T.,
Shiohata N.,
Sano S.,
Moriya S.,
Momiyama H.,
Satoh N.,
Takami S.,
Terashima Y.,
Suzuki O.,
Nakagawa S.,
Senoh A.,
Mizoguchi H.,
Goto Y.,
Shimizu F.,
Wakebe H.,
Hishigaki H.,
Watanabe T.,
Sugiyama A.,
Takemoto M.,
Kawakami B.,
Yamazaki M.,
Watanabe K.,
Kumagai A.,
Itakura S.,
Fukuzumi Y.,
Fujimori Y.,
Komiyama M.,
Tashiro H.,
Tanigami A.,
Fujiwara T.,
Ono T.,
Yamada K.,
Fujii Y.,
Ozaki K.,
Hirao M.,
Ohmori Y.,
Kawabata A.,
Hikiji T.,
Kobatake N.,
Inagaki H.,
Ikema Y.,
Okamoto S.,
Okitani R.,
Kawakami T.,
Noguchi S.,
Itoh T.,
Shigeta K.,
Senba T.,
Matsumura K.,
Nakajima Y.,
Mizuno T.,
Morinaga M.,
Sasaki M.,
Togashi T.,
Oyama M.,
Hata H.,
Watanabe M.,
Komatsu T.,
Mizushima-Sugano J.,
Satoh T.,
Shirai Y.,
Takahashi Y.,
Nakagawa K.,
Okumura K.,
Nagase T.,
Nomura N.,
Kikuchi H.,
Masuho Y.,
Yamashita R.,
Nakai K.,
Yada T.,
Nakamura Y.,
Ohara O.,
Isogai T.,
Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
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[11]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Kalnine N.,
Chen X.,
Rolfs A.,
Halleck A.,
Hines L.,
Eisenstein S.,
Koundinya M.,
Raphael J.,
Moreira D.,
Kelley T.,
LaBaer J.,
Lin Y.,
Phelan M.,
Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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[12]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ASP-34; SER-136; THR-146 AND TRP-164.
SeattleSNPs program for genomic applications;
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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[13]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J.,
Istrail S.,
Sutton G.G.,
Florea L.,
Halpern A.L.,
Mobarry C.M.,
Lippert R.,
Walenz B.,
Shatkay H.,
Dew I.,
Miller J.R.,
Flanigan M.J.,
Edwards N.J.,
Bolanos R.,
Fasulo D.,
Halldorsson B.V.,
Hannenhalli S.,
Turner R.,
Yooseph S., ![]()
Lu F.,
Nusskern D.R.,
Shue B.C.,
Zheng X.H.,
Zhong F.,
Delcher A.L.,
Huson D.H.,
Kravitz S.A.,
Mouchard L.,
Reinert K.,
Remington K.A.,
Clark A.G.,
Waterman M.S.,
Eichler E.E.,
Adams M.D.,
Hunkapiller M.W.,
Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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[14]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
TISSUE=Brain, Placenta, and Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[15]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-36.
PubMed=3161893 [NCBI, ExPASy, EBI, Israel, Japan]
Fisher R.,
Waller E.K.,
Grossi G.,
Thompson D.,
Tizard R.,
Schleuning W.-D.;
"Isolation and characterization of the human tissue-type plasminogen activator structural gene including its 5' flanking region.";
J. Biol. Chem. 260:11223-11230(1985).
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[16]
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NUCLEOTIDE SEQUENCE [MRNA] OF 31-562.
PubMed=1368681 [NCBI, ExPASy, EBI, Israel, Japan]
Itagaki Y.,
Yasuda H.,
Morinaga T.,
Mitsuda S.,
Higashio K.;
"Purification and characterization of tissue plasminogen activator secreted by human embryonic lung diploid fibroblasts, IMR-90 cells.";
Agric. Biol. Chem. 55:1225-1232(1991).
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[17]
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PROTEIN SEQUENCE OF 33-52 AND 311-330.
TISSUE=Melanoma;
PubMed=6682760 [NCBI, ExPASy, EBI, Israel, Japan]
Wallen P.,
Pohl G.,
Bergsdorf N.,
Raanby M.,
Ny T.,
Joernvall H.;
"Purification and characterization of a melanoma cell plasminogen activator.";
Eur. J. Biochem. 132:681-686(1983).
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[18]
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PROTEIN SEQUENCE OF 36-562.
TISSUE=Melanoma;
DOI=10.1021/bi00311a020; PubMed=6433976 [NCBI, ExPASy, EBI, Israel, Japan]
Pohl G.,
Kaellstroem M.,
Bergsdorf N.,
Wallen P.,
Joernvall H.;
"Tissue plasminogen activator: peptide analyses confirm an indirectly derived amino acid sequence, identify the active site serine residue, establish glycosylation sites, and localize variant differences.";
Biochemistry 23:3701-3707(1984).
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[19]
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NUCLEOTIDE SEQUENCE [MRNA] OF 251-358.
PubMed=6572897 [NCBI, ExPASy, EBI, Israel, Japan]
Edlund T.,
Ny T.,
Raanby M.,
Heden L.-O.,
Palm G.,
Holmgren E.,
Josephson S.;
"Isolation of cDNA sequences coding for a part of human tissue plasminogen activator.";
Proc. Natl. Acad. Sci. U.S.A. 80:349-352(1983).
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[20]
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PARTIAL PROTEIN SEQUENCE, AND SIGNAL SEQUENCE CLEAVAGE SITE.
Jalah R.,
Pavlakis G.N.,
Felber B.J.;
Submitted (JUL-2007) to UniProtKB.
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[21]
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STRUCTURE OF CARBOHYDRATES.
PubMed=2513186 [NCBI, ExPASy, EBI, Israel, Japan]
Pfeiffer G.,
Schmidt M.,
Strube K.-H.,
Geyer R.;
"Carbohydrate structure of recombinant human uterine tissue plasminogen activator expressed in mouse epithelial cells.";
Eur. J. Biochem. 186:273-286(1989).
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[22]
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GLYCOSYLATION AT THR-96.
DOI=10.1021/bi00223a004; PubMed=1900431 [NCBI, ExPASy, EBI, Israel, Japan]
Harris R.J.,
Leonard C.K.,
Guzzetta A.W.,
Spellman M.W.;
"Tissue plasminogen activator has an O-linked fucose attached to threonine-61 in the epidermal growth factor domain.";
Biochemistry 30:2311-2314(1991).
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[23]
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DISULFIDE BONDS IN KRINGLE 2.
PubMed=1645336 [NCBI, ExPASy, EBI, Israel, Japan]
Vlahos C.J.,
Wilhelm O.G.,
Hassell T.,
Jaskunas S.R.,
Bang N.U.;
"Disulfide pairing of the recombinant kringle-2 domain of tissue plasminogen activator produced in Escherichia coli.";
J. Biol. Chem. 266:10070-10072(1991).
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[24]
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INTERACTION WITH LRP1B.
DOI=10.1074/jbc.M102727200; PubMed=11384978 [NCBI, ExPASy, EBI, Israel, Japan]
Liu C.-X.,
Li Y.,
Obermoeller-McCormick L.M.,
Schwartz A.L.,
Bu G.;
"The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein.";
J. Biol. Chem. 276:28889-28896(2001).
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[25]
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SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
DOI=10.1186/gb-2004-5-2-r8; PubMed=14759258 [NCBI, ExPASy, EBI, Israel, Japan]
Hillman R.T.,
Green R.E.,
Brenner S.E.;
"An unappreciated role for RNA surveillance.";
Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004).
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[26]
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STRUCTURE BY NMR OF KRINGLE 2.
DOI=10.1021/bi00450a016; PubMed=2558718 [NCBI, ExPASy, EBI, Israel, Japan]
Byeon I.-J.L.,
Kelley R.F.,
Llinas M.;
"1H NMR structural characterization of a recombinant kringle 2 domain from human tissue-type plasminogen activator.";
Biochemistry 28:9350-9360(1989).
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[27]
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STRUCTURE BY NMR OF KRINGLE 2.
PubMed=1901789 [NCBI, ExPASy, EBI, Israel, Japan]
Byeon I.-J.L.,
Kelley R.F.,
Llinas M.;
"Kringle-2 domain of the tissue-type plasminogen activator. 1H-NMR assignments and secondary structure.";
Eur. J. Biochem. 197:155-165(1991).
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[28]
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STRUCTURE BY NMR OF KRINGLE 2.
DOI=10.1016/0022-2836(91)90592-T; PubMed=1762144 [NCBI, ExPASy, EBI, Israel, Japan]
Byeon I.-J.L.,
Llinas M.;
"Solution structure of the tissue-type plasminogen activator kringle 2 domain complexed to 6-aminohexanoic acid an antifibrinolytic drug.";
J. Mol. Biol. 222:1035-1051(1991).
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[29]
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X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF KRINGLE 2.
DOI=10.1021/bi00116a037; PubMed=1310033 [NCBI, ExPASy, EBI, Israel, Japan]
de Vos A.,
Ultsch M.H.,
Kelley R.F.,
Padmanabhan K.,
Tulinskly A.,
Westbrook M.L.,
Kossiakof A.A.;
"Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution.";
Biochemistry 31:270-279(1992).
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[30]
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STRUCTURE BY NMR OF 38-85.
DOI=10.1016/0022-2836(92)90403-7; PubMed=1602484 [NCBI, ExPASy, EBI, Israel, Japan]
Downing A.K.,
Driscoll P.C.,
Harvey T.S.,
Dudgeon T.J.,
Smith B.O.,
Baron M.,
Campbell I.D.;
"Solution structure of the fibrin binding finger domain of tissue-type plasminogen activator determined by 1H nuclear magnetic resonance.";
J. Mol. Biol. 225:821-833(1992).
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[31]
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STRUCTURE BY NMR OF 36-126.
DOI=10.1016/S0969-2126(01)00217-9; PubMed=7582899 [NCBI, ExPASy, EBI, Israel, Japan]
Smith B.O.,
Downing A.K.,
Driscoll P.C.,
Dudgeon T.J.,
Campbell I.D.;
"The solution structure and backbone dynamics of the fibronectin type I and epidermal growth factor-like pair of modules of tissue-type plasminogen activator.";
Structure 3:823-833(1995).
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[32]
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X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF CATALYTIC DOMAIN.
DOI=10.1006/jmbi.1996.0238; PubMed=8613982 [NCBI, ExPASy, EBI, Israel, Japan]
Lamba D.,
Bauer M.,
Huber R.,
Fischer S.,
Rudolph R.,
Kohnert U.,
Bode W.;
"The 2.3 A crystal structure of the catalytic domain of recombinant two-chain human tissue-type plasminogen activator.";
J. Mol. Biol. 258:117-135(1996).
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[33]
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X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF CATALYTIC DOMAIN.
DOI=10.1093/emboj/16.16.4797; PubMed=9305622 [NCBI, ExPASy, EBI, Israel, Japan]
Renatus M.,
Engh R.A.,
Stubbs M.T.,
Huber R.,
Fischer S.,
Kohnert U.,
Bode W.;
"Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA.";
EMBO J. 16:4797-4805(1997).
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