[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1093/nar/13.8.2759; PubMed=2987867 [NCBI, ExPASy, EBI, Israel, Japan]
Riccio A.,
Grimaldi G.,
Verde P.,
Sebastio G.,
Boast S.,
Blasi F.;
"The human urokinase-plasminogen activator gene and its promoter.";
Nucleic Acids Res. 13:2759-2771(1985).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
Holmes W.E.,
Pennica D.,
Blaber M.,
Rey M.W.,
Guenzler W.A.,
Steffens G.J.,
Heyneker H.L.;
"Cloning and expression of the gene for pro-urokinase in Escherichia coli.";
Biotechnology (N.Y.) 3:923-929(1985).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0378-1119(85)90084-8; PubMed=2415429 [NCBI, ExPASy, EBI, Israel, Japan]
Nagai M.,
Hiramatsu R.,
Kaneda T.,
Hayasuke N.,
Arimura H.,
Nishida M.,
Suyama T.;
"Molecular cloning of cDNA coding for human preprourokinase.";
Gene 36:183-188(1985).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3888571 [NCBI, ExPASy, EBI, Israel, Japan]
Jacobs P.,
Cravador A.,
Loriau R.,
Brockly F.,
Colau B.,
Chuchana P.,
van Elsen A.,
Herzog A.,
Bollen A.;
"Molecular cloning, sequencing, and expression in Escherichia coli of human preprourokinase cDNA.";
DNA 4:139-146(1985).
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[5]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS LEU-15; LEU-141 AND GLN-231.
SeattleSNPs program for genomic applications;
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
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[6]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[7]
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PROTEIN SEQUENCE OF 21-43, GLYCOSYLATION AT THR-38, AND MASS SPECTROMETRY.
PubMed=2023947 [NCBI, ExPASy, EBI, Israel, Japan]
Buko A.M.,
Kentzer E.J.,
Petros A.,
Menon G.,
Zuiderweg E.R.,
Sarin V.K.;
"Characterization of a posttranslational fucosylation in the growth factor domain of urinary plasminogen activator.";
Proc. Natl. Acad. Sci. U.S.A. 88:3992-3996(1991).
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[8]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 66-431.
PubMed=6589620 [NCBI, ExPASy, EBI, Israel, Japan]
Verde P.,
Stoppelli M.P.,
Galeffi P.,
di Nocera P.,
Blasi F.;
"Identification and primary sequence of an unspliced human urokinase poly(A)+ RNA.";
Proc. Natl. Acad. Sci. U.S.A. 81:4727-4731(1984).
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[9]
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PROTEIN SEQUENCE OF 21-177.
PubMed=6754569 [NCBI, ExPASy, EBI, Israel, Japan]
Gunzler W.A.,
Steffens G.J.,
Otting F.,
Kim S.-M.A.,
Frankus E.,
Flohe L.;
"The primary structure of high molecular mass urokinase from human urine. The complete amino acid sequence of the A chain.";
Hoppe-Seyler's Z. Physiol. Chem. 363:1155-1165(1982).
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[10]
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PROTEIN SEQUENCE OF 156-176 AND 179-224.
PubMed=6749491 [NCBI, ExPASy, EBI, Israel, Japan]
Schaller J.,
Nick H.,
Rickli E.E.,
Gillessen D.,
Lergier W.,
Studer R.O.;
"Human low-molecular-weight urinary urokinase. Partial characterization and preliminary sequence data of the two polypeptide chains.";
Eur. J. Biochem. 125:251-257(1982).
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[11]
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PROTEIN SEQUENCE OF 158-410.
PubMed=6754572 [NCBI, ExPASy, EBI, Israel, Japan]
Steffens G.J.,
Gunzler W.A.,
Otting F.,
Frankus E.,
Flohe L.;
"The complete amino acid sequence of low molecular mass urokinase from human urine.";
Hoppe-Seyler's Z. Physiol. Chem. 363:1043-1058(1982).
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[12]
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PHOSPHORYLATION AT SER-158 AND SER-323, AND MUTAGENESIS OF SER-158 AND SER-323.
DOI=10.1083/jcb.137.3.779; PubMed=9151681 [NCBI, ExPASy, EBI, Israel, Japan]
Franco P.,
Iaccarino C.,
Chiaradonna F.,
Brandazza A.,
Iavarone C.,
Mastronicola M.R.,
Nolli M.L.,
Stoppelli M.P.;
"Phosphorylation of human pro-urokinase on Ser138/303 impairs its receptor-dependent ability to promote myelomonocytic adherence and motility.";
J. Cell Biol. 137:779-791(1997).
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[13]
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INTERACTION WITH MRC2.
DOI=10.1074/jbc.275.3.1993; PubMed=10636902 [NCBI, ExPASy, EBI, Israel, Japan]
Behrendt N.,
Jensen O.N.,
Engelholm L.H.,
Moertz E.,
Mann M.,
Danoe K.;
"A urokinase receptor-associated protein with specific collagen binding properties.";
J. Biol. Chem. 275:1993-2002(2000).
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[14]
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INTERACTION WITH LRP1B.
DOI=10.1074/jbc.M102727200; PubMed=11384978 [NCBI, ExPASy, EBI, Israel, Japan]
Liu C.-X.,
Li Y.,
Obermoeller-McCormick L.M.,
Schwartz A.L.,
Bu G.;
"The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein.";
J. Biol. Chem. 276:28889-28896(2001).
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[15]
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TISSUE SPECIFICITY.
DOI=10.1128/MCB.25.14.6279-6288.2005; PubMed=15988036 [NCBI, ExPASy, EBI, Israel, Japan]
Ustach C.V.,
Kim H.-R.C.;
"Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells.";
Mol. Cell. Biol. 25:6279-6288(2005).
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[16]
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STRUCTURE BY NMR.
DOI=10.1038/337579a0; PubMed=2536903 [NCBI, ExPASy, EBI, Israel, Japan]
Oswald R.E.,
Bogusky M.J.,
Bamberger M.,
Smith R.A.G.,
Dobson C.M.;
"Dynamics of the multidomain fibrinolytic protein urokinase from two-dimensional NMR.";
Nature 337:579-582(1989).
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[17]
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STRUCTURE BY NMR OF 67-155.
DOI=10.1021/bi00155a008; PubMed=1327118 [NCBI, ExPASy, EBI, Israel, Japan]
Li X.,
Smith R.A.G.,
Dobson C.M.;
"Sequential 1H NMR assignments and secondary structure of the kringle domain from urokinase.";
Biochemistry 31:9562-9571(1992).
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[18]
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STRUCTURE BY NMR OF 67-155.
DOI=10.1006/jmbi.1994.1106; PubMed=8107091 [NCBI, ExPASy, EBI, Israel, Japan]
Li X.,
Bokman A.M.,
Llinas M.,
Smith R.A.G.,
Dobson C.M.;
"Solution structure of the kringle domain from urokinase-type plasminogen activator.";
J. Mol. Biol. 235:1548-1559(1994).
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[19]
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X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
DOI=10.1016/S0969-2126(01)00203-9; PubMed=8591045 [NCBI, ExPASy, EBI, Israel, Japan]
Spraggon G.,
Phillips C.,
Nowak U.K.,
Ponting C.P.,
Saunders D.,
Dobson C.M.,
Stuart D.I.,
Jones E.Y.;
"The crystal structure of the catalytic domain of human urokinase-type plasminogen activator.";
Structure 3:681-691(1995).
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[20]
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X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 159-411.
DOI=10.1073/pnas.97.10.5113; PubMed=10805774 [NCBI, ExPASy, EBI, Israel, Japan]
Sperl S.,
Jacob U.,
Arroyo de Prada N.,
Sturzebecher J.,
Wilhelm O.G.,
Bode W.,
Magdolen V.,
Huber R.,
Moroder L.;
"(4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase.";
Proc. Natl. Acad. Sci. U.S.A. 97:5113-5118(2000).
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[21]
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X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 31-152 IN COMPLEX WITH PLAUR.
DOI=10.1126/science.1121143; PubMed=16456079 [NCBI, ExPASy, EBI, Israel, Japan]
Huai Q.,
Mazar A.P.,
Kuo A.,
Parry G.C.,
Shaw D.E.,
Callahan J.,
Li Y.,
Yuan C.,
Bian C.,
Chen L.,
Furie B.,
Furie B.C.,
Cines D.B.,
Huang M.;
"Structure of human urokinase plasminogen activator in complex with its receptor.";
Science 311:656-659(2006).
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[22]
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VARIANT LEU-141.
PubMed=8652631 [NCBI, ExPASy, EBI, Israel, Japan]
Yoshimoto M.,
Ushiyama Y.,
Sakai M.,
Tamaki S.,
Hara H.,
Takahashi K.,
Sawasaki Y.,
Hanada K.;
"Characterization of single chain urokinase-type plasminogen activator with a novel amino-acid substitution in the kringle structure.";
Biochim. Biophys. Acta 1293:83-89(1996).
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[23]
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VARIANT LEU-141.
PubMed=9065988 [NCBI, ExPASy, EBI, Israel, Japan]
Conne B.,
Berczy M.,
Belin D.;
"Detection of polymorphisms in the human urokinase-type plasminogen activator gene.";
Thromb. Haemost. 77:434-435(1997).
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[24]
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ERRATUM.
Conne B.,
Berczy M.,
Belin D.;
Thromb. Haemost. 78:973-973(1997).
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[25]
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VARIANT LEU-141.
PubMed=9194591 [NCBI, ExPASy, EBI, Israel, Japan]
Turkmen B.,
Schmitt M.,
Schmalfeldt B.,
Trommler P.,
Hell W.,
Creutzburg S.,
Graeff H.,
Magdolen V.;
"Mutational analysis of the genes encoding urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in advanced ovarian cancer.";
Electrophoresis 18:686-689(1997).
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