[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=Sprague-Dawley; DOI=10.1006/mpev.1993.1007; PubMed=8081549 [NCBI, ExPASy, EBI, Israel, Japan] Yeh T.C., Wilson A.C., Irwin D.M.; "Evolution of rodent lysozymes: isolation and sequence of the rat lysozyme genes."; Mol. Phylogenet. Evol. 2:65-75(1993).
[2]	PROTEIN SEQUENCE OF 19-148. STRAIN=Wistar; DOI=10.1021/bi00626a030; PubMed=851497 [NCBI, ExPASy, EBI, Israel, Japan] White T.J., Mross G.A., Osserman E.F., Wilson A.C.; "Primary structure of rat lysozyme."; Biochemistry 16:1430-1436(1977).

Comments

FUNCTION: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. In the intestine they may also have a digestive function.
CATALYTIC ACTIVITY: Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
SUBUNIT: Monomer.
TISSUE SPECIFICITY: Expressed in lung, small intestine and spleen.
MISCELLANEOUS: Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.
MISCELLANEOUS: Rat has two lysozymes, type 1 and type 2 of which only type 1 is expressed; type 2 being probably a pseudogene.
SIMILARITY: Belongs to the glycosyl hydrolase 22 family [view classification].

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L12459; AAA41551.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A40729; LZRT.

UniGene

Rn.2283

3D structure databases

HSSP

P08905; 1IVM. [HSSP ENTRY / PDB]

SMR

P00697; 19-148.

ModBase

P00697.

Organism-specific databases

RGD

3026; Lyz.

Gene expression databases

ArrayExpress

P00697; -.

GermOnline

ENSRNOG00000005825; Rattus norvegicus.

Ontologies

GO:0019835;	Biological process: cytolysis (inferred from electronic annotation from UniProtKB-KW).
GO:0042742;	Biological process: defense response to bacterium (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR001916; Glyco_hydro_22.
IPR000974; Glyco_hydro_22_lys.
Graphical view of domain structure.

Pfam

PF00062; Lys; 1.
Pfam graphical view of domain structure.

PRINTS

PR00137; LYSOZYME.
PR00135; LYZLACT.

SMART

SM00263; LYZ1; 1.
SMART graphical view of domain structure.

PROSITE

PS00128; LACTALBUMIN_LYSOZYME_1; 1.
PS51348; LACTALBUMIN_LYSOZYME_2; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

Ensembl

ENSRNOG00000005825; Rattus norvegicus. [Contig view]

Phylogenomic databases

HOVERGEN

P00697; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Antimicrobial; Bacteriolytic enzyme; Direct protein sequencing; Glycosidase; Hydrolase; Milk protein; Signal.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 18`	`18`
`CHAIN`	`19 148`	`130`	`Lysozyme C-1.`	`PRO_0000018484`
`ACT_SITE`	`53 53`		`By similarity.`
`ACT_SITE`	`71 71`		`By similarity.`
`DISULFID`	`24 146`		`By similarity.`
`DISULFID`	`48 134`		`By similarity.`
`DISULFID`	`83 99`		`By similarity.`
`DISULFID`	`95 113`		`By similarity.`
`CONFLICT`	`20 20`		`I -> T (in Ref. 2; AA sequence).`
`CONFLICT`	`64 64`		`N -> D (in Ref. 2; AA sequence).`

Sequence information

Length: 148 AA [This is the length of the unprocessed precursor]

Molecular weight: 16729 Da [This is the MW of the unprocessed precursor]

CRC64: 8E6E986539BD3EEE [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKALLVLGFL LLSASVQAKI YERCQFARTL KRNGMSGYYG VSLADWVCLA QHESNYNTQA 

        70         80         90        100        110        120 
RNYNPGDQST DYGIFQINSR YWCNDGKTPR AKNACGIPCS ALLQDDITQA IQCAKRVVRD 

       130        140 
PQGIRAWVAW QRHCKNRDLS GYIRNCGV

P00697 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools