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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Venom gland;
DOI=10.1093/nar/18.15.4609; PubMed=2388842 [NCBI, ExPASy, EBI, Israel, Japan]
Danse J.-M.,
Toussaint J.L.,
Kempf J.;
"Nucleotide sequence encoding beta-bungarotoxin A2-chain from the venom glands of Bungarus multicinctus.";
Nucleic Acids Res. 18:4609-4609(1990).
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[2]
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PROTEIN SEQUENCE OF 26-145.
TISSUE=Venom;
PubMed=7096305 [NCBI, ExPASy, EBI, Israel, Japan]
Kondo K.,
Toda H.,
Narita K.,
Lee C.-Y.;
"Amino acid sequences of three beta-bungarotoxins (beta 3-, beta 4-, and beta 5-bungarotoxins) from Bungarus multicinctus venom. Amino acid substitutions in the A chains.";
J. Biochem. 91:1531-1548(1982).
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[3]
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REVIEW.
DOI=10.1016/S0041-0101(00)00159-8; PubMed=10936627 [NCBI, ExPASy, EBI, Israel, Japan]
Rowan E.G.;
"What does beta-bungarotoxin do at the neuromuscular junction?";
Toxicon 39:107-118(2001).
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- FUNCTION: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. Acts presynaptically.
- CATALYTIC ACTIVITY: Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
- COFACTOR: Binds 1 calcium ion (By similarity).
- SUBUNIT: Heterodimer; disulfide-linked. The A chains have phospholipase A2 activity and the B chains show homology with the basic protease inhibitors. The A2 chain is found in beta-3 and beta-4 bungarotoxins.
- SUBCELLULAR LOCATION: Secreted.
- TISSUE SPECIFICITY: Expressed by the venom gland.
- TOXIC DOSE: LD50 is 0.066 mg/kg by intraperitoneal injection in beta-3 bungarotoxin and 0.073 mg/kg in beta-4.
- SIMILARITY: Belongs to the phospholipase A2 family. Group I subfamily.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 145 AA [This is the length of the unprocessed precursor] |
Molecular weight: 16296 Da [This is the MW of the unprocessed precursor] |
CRC64: 08CD9D0E84E57581 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MLIFLWCGAV CVSLLGAANI PPHPLNLINF MEMIRYTIPC EKTWGEYADY GCYCGAGGSG
70 80 90 100 110 120
RPIDALDRCC YVHDNCYGDA EKKHKCNPKT QSYSYKLTKR TIICYGAAGT CARIVCDCDR
130 140
TAALCFGNSE YIERHKNIDT KRHCR
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P00618 in FASTA format |
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