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UniProtKB/Swiss-Prot entry P00611


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PA21B_LATSE
Primary accession number P00611
Secondary accession number Q9I848
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on November 1, 2002 (Sequence version 3)
Annotations were last modified on    September 2, 2008 (Entry version 71)
Name and origin of the protein
Protein name Phospholipase A2 isozyme 1 [Precursor]
Synonyms EC 3.1.1.4
Phospholipase A2 isozyme I
Phosphatidylcholine 2-acylhydrolase
GL5-1
Gene name None
From
Laticauda semifasciata (Broad-banded blue sea snake) (Erabu sea snake) [TaxID: 8631] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Scleroglossa; Serpentes; Colubroidea; Elapidae; Laticaudinae; Laticauda.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Liver;
DOI=10.1016/S0041-0101(01)00272-0; PubMed=12076640 [NCBI, ExPASy, EBI, Israel, Japan]
Fujimi T.J., Tsuchiya T., Tamiya T.;
"A comparative analysis of invaded sequences from group IA phospholipase A(2) genes provides evidence about the divergence period of genes groups and snake families.";
Toxicon 40:873-884(2002).
[2]
PROTEIN SEQUENCE OF 28-145.
TISSUE=Venom;
PubMed=7165712 [NCBI, ExPASy, EBI, Israel, Japan]
Nishida S., Kim H.S., Tamiya N.;
"Amino acid sequences of three phospholipases A I, III and IV from the venom of the sea snake Laticauda semifasciata.";
Biochem. J. 207:589-594(1982).
[3]
SEQUENCE REVISION TO 97-107.
DOI=10.1016/0041-0101(88)90281-4; PubMed=3188064 [NCBI, ExPASy, EBI, Israel, Japan]
Takasaki C., Kuramochi H., Shimazu T., Tamiya N.;
"Correction of amino acid sequence of phospholipase A2 I from the venom of Laticauda semifasciata (Erabu sea snake).";
Toxicon 26:747-749(1988).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB062440; BAB72247.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A94325; PSLT1E.
3D structure databases
HSSP P00608; 1AE7. [HSSP ENTRY / PDB]
ModBase P00611.
Family and domain databases
InterPro IPR016090; Phospholipase_A2.
IPR013090; Phospholipase_A2_AS.
IPR001211; Phospholipase_A2_euk.
Graphical view of domain structure.
Gene3D G3DSA:1.20.90.10; Phospholipase_A2; 1.
PANTHER PTHR11716; Phospholipase_A2; 1.
Pfam PF00068; Phospholip_A2_1; 1.
Pfam graphical view of domain structure.
PRINTS PR00389; PHPHLIPASEA2.
ProDom PD000303; PhospholipaseA2; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00085; PA2c; 1.
SMART graphical view of domain structure.
PROSITE PS00119; PA2_ASP; 1.
PS00118; PA2_HIS; 1.
BLOCKS P00611.
Phylogenomic databases
HOVERGEN P00611; -.
Other
ProtoNet P00611.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Calcium; Direct protein sequencing; Hydrolase; Lipid degradation; Metal-binding; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    21  21     Potential. 
PROPEP   22    27  6      PRO_0000022896
CHAIN   28   145  118     Phospholipase A2 isozyme 1. PRO_0000022897
ACT_SITE   75    75        By similarity. 
ACT_SITE   119   119        By similarity. 
METAL   55    55        Calcium; via carbonyl oxygen (By similarity). 
METAL   57    57        Calcium; via carbonyl oxygen (By similarity). 
METAL   59    59        Calcium; via carbonyl oxygen (By similarity). 
METAL   76    76        Calcium (By similarity). 
SITE   91    91  1     Specific activity reduced 20-fold by modification. 
DISULFID   38    98        By similarity. 
DISULFID   54   144        By similarity. 
DISULFID   56    72        By similarity. 
DISULFID   71   125        By similarity. 
DISULFID   78   118        By similarity. 
DISULFID   87   111        By similarity. 
DISULFID   105   116        By similarity. 
CONFLICT   39    40        VN -> NV (in Ref. 2; AA sequence). 
CONFLICT   77    77        D -> N (in Ref. 2; AA sequence). 
Sequence information
Length: 145 AA [This is the length of the unprocessed precursor] Molecular weight: 15900 Da [This is the MW of the unprocessed precursor] CRC64: 1F84DF6F7BC5348F [This is a checksum on the sequence]
        10         20         30         40         50         60 
MYPAHLLVLL AVCVSLLGAT AIPPLPLNLV QFSNLIQCVN KGSRASYHYA DYGCYCGAGG 

        70         80         90        100        110        120 
SGTPVDELDR CCKIHDDCYG EAEKMGCYPK WTLYTYDCST EEPNCSTKTG CQGFVCACDL 

       130        140 
EAAKCFARSP YNNKNYNIDT SKRCK 

P00611 in FASTA format

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