[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Pancreas;
DOI=10.1093/nar/15.9.3743; PubMed=3295782 [NCBI, ExPASy, EBI, Israel, Japan]
de Geus P.,
van den Bergh C.J.,
Kuipers O.,
Verheij H.M.,
Hoekstra W.P.M.,
de Haas G.H.;
"Expression of porcine pancreatic phospholipase A2. Generation of active enzyme by sequence-specific cleavage of a hybrid protein from Escherichia coli.";
Nucleic Acids Res. 15:3743-3759(1987).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Pancreas;
PubMed=3028739 [NCBI, ExPASy, EBI, Israel, Japan]
Seilhamer J.J.,
Randall T.L.,
Yamanaka M.,
Johnson L.K.;
"Pancreatic phospholipase A2: isolation of the human gene and cDNAs from porcine pancreas and human lung.";
DNA 5:519-527(1986).
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[3]
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PROTEIN SEQUENCE OF 16-146.
PubMed=5528841 [NCBI, ExPASy, EBI, Israel, Japan]
de Haas G.H.,
Slotboom A.J.,
Bonsen P.P.M.,
van Deenen L.L.M.,
Maroux S.,
Puigserver A.,
Desnuelle P.;
"Studies on phospholipase A and its zymogen from porcine pancreas. I. The complete amino acid sequence.";
Biochim. Biophys. Acta 221:31-53(1970).
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[4]
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SEQUENCE REVISION.
DOI=10.1016/0005-2795(77)90076-9; PubMed=884127 [NCBI, ExPASy, EBI, Israel, Japan]
Puijk W.C.,
Verheij H.M.,
de Haas G.H.;
"The primary structure of phospholipase A2 from porcine pancreas. A reinvestigation.";
Biochim. Biophys. Acta 492:254-259(1977).
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[5]
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DISULFIDE BONDS.
PubMed=4919729 [NCBI, ExPASy, EBI, Israel, Japan]
de Haas G.H.,
Slotboom A.J.,
Bonsen P.P.M.,
Nieuwenhuizen W.,
van Deenen L.L.M.,
Maroux S.,
Dlouha V.,
Desnuelle P.;
"Studies on phospholipase A and its zymogen from porcine pancreas. II. The assignment of the position of the six disulfide bridges.";
Biochim. Biophys. Acta 221:54-61(1970).
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[6]
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PALMITOYLATION AT LYS-78.
TISSUE=Pancreas;
PubMed=2498336 [NCBI, ExPASy, EBI, Israel, Japan]
Tomasselli A.G.,
Hui J.,
Fisher J.,
Zuercher-Neely H.,
Reardon H.M.,
Oriaku E.,
Kezdy F.J.,
Heinrikson R.L.;
"Dimerization and activation of porcine pancreatic phospholipase A2 via substrate level acylation of lysine 56.";
J. Biol. Chem. 264:10041-10047(1989).
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[7]
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X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS), AND ACTIVE AND BINDING SITES.
DOI=10.1016/S0022-2836(83)80328-3; PubMed=6876174 [NCBI, ExPASy, EBI, Israel, Japan]
Dijkstra B.W.,
Renetseder R.,
Kalk K.H.,
Hol W.G.J.,
Drenth J.;
"Structure of porcine pancreatic phospholipase A2 at 2.6-A resolution and comparison with bovine phospholipase A2.";
J. Mol. Biol. 168:163-179(1983).
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[8]
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X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
DOI=10.1016/S0022-2836(05)80332-8; PubMed=2254938 [NCBI, ExPASy, EBI, Israel, Japan]
Thunnissen M.M.G.M.,
Kalk K.H.,
Drenth J.,
Dijkstra B.W.;
"Structure of an engineered porcine phospholipase A2 with enhanced activity at 2.1-A resolution. Comparison with the wild-type porcine and Crotalus atrox phospholipase A2.";
J. Mol. Biol. 216:425-439(1990).
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[9]
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X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
DOI=10.1038/347689a0; PubMed=2215698 [NCBI, ExPASy, EBI, Israel, Japan]
Thunnissen M.M.G.M.,
Ab E.,
Kalk K.H.,
Drenth J.,
Dijkstra B.W.,
Kuipers O.P.,
Dijkman R.,
de Haas G.H.,
Verheij H.M.;
"X-ray structure of phospholipase A2 complexed with a substrate-derived inhibitor.";
Nature 347:689-691(1990).
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[10]
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STRUCTURE BY NMR.
DOI=10.1021/bi00226a022; PubMed=2007145 [NCBI, ExPASy, EBI, Israel, Japan]
Dekker N.,
Peters A.R.,
Slotboom A.J.,
Boelens R.,
Kaptein R.,
de Haas G.H.;
"Porcine pancreatic phospholipase A2: sequence-specific 1H and 15N NMR assignments and secondary structure.";
Biochemistry 30:3135-3147(1991).
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[11]
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STRUCTURE BY NMR.
DOI=10.1038/nsb0595-402; PubMed=7664098 [NCBI, ExPASy, EBI, Israel, Japan]
van den Berg B.,
Tessari M.,
Boelens R.,
Dijkman R.,
de Haas G.H.,
Kaptein R.,
Verheij H.M.;
"NMR structures of phospholipase A2 reveal conformational changes during interfacial activation.";
Nat. Struct. Biol. 2:402-406(1995).
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[12]
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STRUCTURE BY NMR.
PubMed=7556053 [NCBI, ExPASy, EBI, Israel, Japan]
van den Berg B.,
Tessari M.,
de Haas G.H.,
Verheij H.M.,
Boelens R.,
Kaptein R.;
"Solution structure of porcine pancreatic phospholipase A2.";
EMBO J. 14:4123-4131(1995).
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[13]
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STRUCTURE BY NMR.
DOI=10.1007/BF00208802; PubMed=7703697 [NCBI, ExPASy, EBI, Israel, Japan]
van den Berg B.,
Tessari M.,
Boelens R.,
Dijkman R.,
Kaptein R.,
de Haas G.H.,
Verheij H.M.;
"Solution structure of porcine pancreatic phospholipase A2 complexed with micelles and a competitive inhibitor.";
J. Biomol. NMR 5:110-121(1995).
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