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- FUNCTION: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
- CATALYTIC ACTIVITY: ATP + creatine = ADP + phosphocreatine.
- SUBUNIT: Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.
- SUBCELLULAR LOCATION: Cytoplasm.
- MISCELLANEOUS: This electric ray muscle-specific creatine kinase (MM isozyme) is isolated from the electric organ, which derives embryologically from skeletal muscle. It may be involved in the electrical discharge process.
- SIMILARITY: Belongs to the ATP:guanido phosphotransferase family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 381 AA [This is the length of the unprocessed precursor] |
Molecular weight: 42974 Da [This is the MW of the unprocessed precursor] |
CRC64: AE0217EB65B8772C [This is a checksum on the sequence] |
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10 20 30 40 50 60
MPFGNTHNKW KLNYSAAEEF PDLSKHNNHM AKALTLDIYK KLRDKETPSG FTLDDVIQTG
70 80 90 100 110 120
VDNPGHPFIM TVGCVAGDEE CYEVFKDLFD PVIEDRHGGY KPTDKHKTDL NQDNLKGGDD
130 140 150 160 170 180
LDPNYVLSSR VRTGRSIKGI ALPPHCSRGE RRLVEKLCIE GLATLTGEFQ GKYYPLSTMS
190 200 210 220 230 240
DAEQQQLIDD HFLFDKPISP LLLASGMARD WPDGRGIWHN NDKSFLVWVN EEDHLRVISM
250 260 270 280 290 300
QKGGNMKEVF RRFCVGLKKI EEIFVKAGRG FMWNEHLGYV LTCPSNLGTG LRGGVHVKIP
310 320 330 340 350 360
HLCKHEKFSE VLKRTRLQKR GTGGVDTEAV GSIYDISNAD RLGFSEVEQV QMVVDGVKLM
370 380
VEMEKRLENG KSIDDLIPAQ K
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P00566 in FASTA format |
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