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UniProtKB/Swiss-Prot entry P00548

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name KPYK_CHICK
Primary accession number P00548
Secondary accession numbers None
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 64)
Name and origin of the protein
Protein name Pyruvate kinase muscle isozyme
Synonym EC 2.7.1.40
Gene name
Name: PKM2
From
Gallus gallus (Chicken) [TaxID: 9031] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
PubMed=6574503 [NCBI, ExPASy, EBI, Israel, Japan]
Lonberg N., Gilbert W.;
"Primary structure of chicken muscle pyruvate kinase mRNA.";
Proc. Natl. Acad. Sci. U.S.A. 80:3661-3665(1983).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0092-8674(85)90311-3; PubMed=2981634 [NCBI, ExPASy, EBI, Israel, Japan]
Lonberg N., Gilbert W.;
"Intron/exon structure of the chicken pyruvate kinase gene.";
Cell 40:81-90(1985).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
J00903; AAA49021.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M18793; AAA49020.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M10619; AAA49020.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M18788; AAA49020.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M18789; AAA49020.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M18790; AAA49020.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M18791; AAA49020.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M18792; AAA49020.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR I50408; KICHPM.
RefSeq NP_990800.1; -.
UniGene Gga.4299
3D structure databases
HSSP P11974; 1PKN. [HSSP ENTRY / PDB]
SMR P00548; 10-530.
ModBase P00548.
Family and domain databases
InterPro IPR001697; Pyr_Knase.
IPR015813; Pyrv/PenolPyrv_Kinase_cat.
IPR015794; Pyrv_Knase_a/b.
IPR015793; Pyrv_Knase_brl.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.60; Pyrv/PenolPyrv_Kinase_cat; 1.
G3DSA:3.40.1380.20; Pyrv_Knase_a/b; 1.
PANTHER PTHR11817; Pyruvate_kinase; 1.
Pfam PF00224; PK; 1.
PF02887; PK_C; 1.
Pfam graphical view of domain structure.
ProDom PD001009; Pyruvate_kinase; 2.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01064; pyruv_kin; 1.
PROSITE PS00110; PYRUVATE_KINASE; 1.
BLOCKS P00548.
ProtoNet P00548.
Genome annotation databases
Ensembl ENSGALG00000001992; Gallus gallus. [Contig view]
GeneID 396456; -.
KEGG gga:396456; -.
Phylogenomic databases
HOVERGEN P00548; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Glycolysis; Kinase; Magnesium; Metal-binding; Phosphoprotein; Pyruvate; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   530  529     Pyruvate kinase muscle isozyme. PRO_0000112097
ACT_SITE   269   269        By similarity. 
METAL   271   271        Magnesium (Potential). 
METAL   292   292        Magnesium (Potential). 
METAL   293   293        Magnesium (Potential). 
Sequence information
Length: 530 AA [This is the length of the unprocessed precursor] Molecular weight: 58015 Da [This is the MW of the unprocessed precursor] CRC64: 8B0DF09FD82EB72F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSKHHDAGTA FIQTQQLHAA MADTFLEHMC RLDIDSEPTI ARNTGIICTI GPASRSVDKL 

        70         80         90        100        110        120 
KEMIKSGMNV ARLNFSHGTH EYHEGTIKNV REATESFASD PITYRPVAIA LDTKGPEIRT 

       130        140        150        160        170        180 
GLIKGSGTAE VELKKGAALK VTLDNAFMEN CDENVLWVDY KNLIKVIDVG SKIYVDDGLI 

       190        200        210        220        230        240 
SLLVKEKGKD FVMTEVENGG MLGSKKGVNL PGAAVDLPAV SEKDIQDLKF GVEQNVDMVF 

       250        260        270        280        290        300 
ASFIRKAADV HAVRKVLGEK GKHIKIISKI ENHEGVRRFD EIMEASDGIM VARGDLGIEI 

       310        320        330        340        350        360 
PAEKVFLAQK MMIGRCNRAG KPIICATQML ESMIKKPRPT RAEGSDVANA VLDGADCIML 

       370        380        390        400        410        420 
SGETAKGDYP LEAVRMQHAI AREAEAAMFH RQQFEEILRH SVHHREPADA MAAGAVEASF 

       430        440        450        460        470        480 
KCLAAALIVM TESGRSAHLV SRYRPRAPII AVTRNDQTAR QAHLYRGVFP VLCKQPAHDA 

       490        500        510        520        530 
WAEDVDLRVN LGMNVGKARG FFKTGDLVIV LTGWRPGSGY TNTMRVVPVP
P00548 in FASTA format

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