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UniProtKB/Swiss-Prot entry P00544

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FGR_FSVGR
Primary accession number P00544
Secondary accession numbers None
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on July 21, 1986 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 73)
Name and origin of the protein
Protein name Tyrosine-protein kinase transforming protein Fgr
Synonym EC 2.7.10.2
Gene name
Name: V-FGR
Synonyms: SRC-2
From
Feline sarcoma virus (strain Gardner-Rasheed) [TaxID: 11775] 
Taxonomy Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Gammaretrovirus.
Virus host Felidae (cat family) [TaxID: 9681]
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=6318314 [NCBI, ExPASy, EBI, Israel, Japan]
Naharro G., Robbins K.C., Reddy E.P.;
"Gene product of v-fgr onc: hybrid protein containing a portion of actin and a tyrosine-specific protein kinase.";
Science 223:63-66(1984).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X00255; CAA25063.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A00653; TVMVRR.
3D structure databases
HSSP P10983; 1D4X. [HSSP ENTRY / PDB]
SMR P00544; 26-164, 147-543.
ModBase P00544.
Ontologies
GO
GO:0004715; Molecular function: non-membrane spanning protein tyrosine kinase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR004001; Actin_CS.
IPR004000; Actin_like.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR000980; SH2.
IPR001245; Tyr_pkinase.
IPR008266; Tyr_pkinase_AS.
Graphical view of domain structure.
Gene3D G3DSA:3.30.505.10; SH2; 1.
Pfam PF00022; Actin; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
Pfam graphical view of domain structure.
PRINTS PR00190; ACTIN.
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
ProDom PD000001; Prot_kinase; 1.
PD000093; SH2; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00268; ACTIN; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 1.
SMART graphical view of domain structure.
PROSITE PS00406; ACTINS_1; 1.
PS01132; ACTINS_ACT_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P00544.
ProtoNet P00544.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Kinase; Nucleotide-binding; Oncogene; Phosphoprotein; SH2 domain; Transferase; Tyrosine-protein kinase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   545  545     Tyrosine-protein kinase transforming protein Fgr. PRO_0000088090
DOMAIN   167   264  98     SH2. 
DOMAIN   286   539  254     Protein kinase. 
NP_BIND   292   300  9     ATP (By similarity). 
REGION   23   157  135     Actin. 
ACT_SITE   405   405        Proton acceptor (By similarity). 
BINDING   314   314        ATP (By similarity). 
MOD_RES   435   435        Phosphotyrosine; by autocatalysis (By similarity). 
Sequence information
Length: 545 AA [This is the length of the unprocessed precursor] Molecular weight: 61516 Da [This is the MW of the unprocessed precursor] CRC64: 7F4742EB7A7C413E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
ARALCRPAVC RPRPLPPLPP TAMEEEVAAL VIDNGSGMCK AGFAGDDAPR AVFPSIVGRP 

        70         80         90        100        110        120 
RHQGVMVGMG QKDSYVGDEA QSKRGILTLK YPIEHGIVTN WDDMEKIWHH TFYNELRVAP 

       130        140        150        160        170        180 
EEHPVLLTEA PLNPKANREK MTQIMFETFN IPSNYVAPVD SIQAEEWYFG KIGRKDAERQ 

       190        200        210        220        230        240 
LLSPGNARGA FLVRESETTK GAYSLSIRDW DEARGDHVKH YKIRKLDTGG YYITTRAQFN 

       250        260        270        280        290        300 
SVQELVQHYV EVNDGLCHLL TAACTTMKPQ TMGLAKDAWE ISRSSITLQR RLGTGCFGDV 

       310        320        330        340        350        360 
WLGMWNGSTK VAVKTLKPGT MSPKASLEEA QIMKLLRHDK LVQLYAVVPE EPIYIVTEFM 

       370        380        390        400        410        420 
CHGSLLEFLK DQEGQDLTLP QLVDMAAQVA EGMAYMERMD YIHRDLRAAN ILVGERLVCK 

       430        440        450        460        470        480 
IADFGLARLI EDNEYNPRQG AKFPIKWTAP EAALFGRFTI KSDVWSFGIL LTELISKGRV 

       490        500        510        520        530        540 
PYPGMNNREV LEQVEHGYHM PCPPGCPASL YEAMEQTWRL DPEERPTFEY LQSFLEDYFN 


GPQQN
P00544 in FASTA format

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