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UniProtKB/Swiss-Prot entry P00543

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FES_FSVST
Primary accession number P00543
Secondary accession numbers None
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on July 21, 1986 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 69)
Name and origin of the protein
Protein name Tyrosine-protein kinase transforming protein Fes
Synonym EC 2.7.10.2
Gene name
Name: V-FES
From
Feline sarcoma virus (strain Snyder-Theilen) [TaxID: 11780] 
Taxonomy Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Gammaretrovirus.
Virus host Felidae (cat family) [TaxID: 9681]
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC RNA].
DOI=10.1016/0092-8674(82)90282-3; PubMed=6183005 [NCBI, ExPASy, EBI, Israel, Japan]
Hampe A., Laprevotte I., Galibert F., Fedele L.A., Sherr C.J.;
"Nucleotide sequences of feline retroviral oncogenes (v-fes) provide evidence for a family of tyrosine-specific protein kinase genes.";
Cell 30:775-785(1982).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
J02088; AAA43046.2; ALT_INIT; Genomic_RNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A00652; TVMVCS.
3D structure databases
HSSP P11362; 1FGK. [HSSP ENTRY / PDB]
ModBase P00543.
Ontologies
GO
GO:0004715; Molecular function: non-membrane spanning protein tyrosine kinase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR000980; SH2.
IPR001245; Tyr_pkinase.
IPR008266; Tyr_pkinase_AS.
Graphical view of domain structure.
Gene3D G3DSA:3.30.505.10; SH2; 1.
Pfam PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
Pfam graphical view of domain structure.
PRINTS PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
ProDom PD000001; Prot_kinase; 1.
PD000093; SH2; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00252; SH2; 1.
SM00219; TyrKc; 1.
SMART graphical view of domain structure.
PROSITE PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P00543.
ProtoNet P00543.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Kinase; Nucleotide-binding; Oncogene; Phosphoprotein; SH2 domain; Transferase; Tyrosine-protein kinase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   477  477     Tyrosine-protein kinase transforming protein Fes. PRO_0000088086
DOMAIN   115   204  90     SH2. 
DOMAIN   216   477  262     Protein kinase. 
NP_BIND   222   230  9     ATP (By similarity). 
ACT_SITE   338   338        Proton acceptor (By similarity). 
BINDING   245   245        ATP (By similarity). 
MOD_RES   368   368        Phosphotyrosine; by autocatalysis (By similarity). 
Sequence information
Length: 477 AA [This is the length of the unprocessed precursor] Molecular weight: 53757 Da [This is the MW of the unprocessed precursor] CRC64: BB87EDB4E7A3BEB5 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
HPREQVQLLA KKQVLQEALQ ALQVALCSQA KLQAQRELLQ AKLEQLGPGE PPPVLLLQDD 

        70         80         90        100        110        120 
RHSTSSSEQE REGGRTPTLE ILKSHISGIF RPKFSLPPPL QLVPEVQKPL HEQLWYHGAL 

       130        140        150        160        170        180 
PRAEVAELLT HSGDFLVRES QGKQEYVLSV LWDGQPRHFI IQSADNLYRP EGDGFASIPL 

       190        200        210        220        230        240 
LVDHLLRSQQ PLTKKSGIVL NRAVPKDKWV LNHEDLVLGE QIGRGNFGEV FSGRLRADNT 

       250        260        270        280        290        300 
LVAVKSCRET LPPDIKAKFL QEAKILKQYS HPNIVRLIGV CTQKQPIYIV MELVQGGDFL 

       310        320        330        340        350        360 
TFLRTEGARL RMKTLLQMVG DAAAGMEYLE SKCCIHRDLA ARNCLVTEKN VLKISDFGMS 

       370        380        390        400        410        420 
REEADGVYAA SGGLRLVPVK WTAPEALNYG RYSSESDVWS FGILLWETFS LGASPYPNLS 

       430        440        450        460        470 
NQQTREFVEK GGRLPCPELC PDAVFRLMEQ CWAYEPGQRP SFSAFYQELQ SIRKRHR
P00543 in FASTA format

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