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UniProtKB/Swiss-Prot entry P00542

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FES_FSVGA
Primary accession number P00542
Secondary accession numbers None
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on July 21, 1986 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 71)
Name and origin of the protein
Protein name Tyrosine-protein kinase transforming protein Fes
Synonym EC 2.7.10.2
Gene name
Name: V-FES
From
Feline sarcoma virus (strain Gardner-Arnstein) (Ga-FeSV) (Gardner-Arnstein feline leukemia oncovirus B) [TaxID: 11774] 
Taxonomy Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Gammaretrovirus.
Virus host Felidae (cat family) [TaxID: 9681]
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC RNA].
DOI=10.1016/0092-8674(82)90282-3; PubMed=6183005 [NCBI, ExPASy, EBI, Israel, Japan]
Hampe A., Laprevotte I., Galibert F., Fedele L.A., Sherr C.J.;
"Nucleotide sequences of feline retroviral oncogenes (v-fes) provide evidence for a family of tyrosine-specific protein kinase genes.";
Cell 30:775-785(1982).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
J02087; AAA43041.1; ALT_INIT; Genomic_RNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A00651; TVMVGC.
3D structure databases
HSSP P11362; 1FGK. [HSSP ENTRY / PDB]
ModBase P00542.
Ontologies
GO
GO:0004715; Molecular function: non-membrane spanning protein tyrosine kinase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR001060; Cdc15_Fes_CIP4.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR000980; SH2.
IPR001245; Tyr_pkinase.
IPR008266; Tyr_pkinase_AS.
Graphical view of domain structure.
Gene3D G3DSA:3.30.505.10; SH2; 1.
Pfam PF00611; FCH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
Pfam graphical view of domain structure.
PRINTS PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
ProDom PD000001; Prot_kinase; 1.
PD000093; SH2; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00055; FCH; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 1.
SMART graphical view of domain structure.
PROSITE PS50133; FCH; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P00542.
ProtoNet P00542.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Kinase; Nucleotide-binding; Oncogene; Phosphoprotein; SH2 domain; Transferase; Tyrosine-protein kinase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   609  609     Tyrosine-protein kinase transforming protein Fes. PRO_0000088087
DOMAIN   8   101  94     FCH. 
DOMAIN   247   336  90     SH2. 
DOMAIN   348   609  262     Protein kinase. 
NP_BIND   354   362  9     ATP (By similarity). 
ACT_SITE   470   470        Proton acceptor (By similarity). 
BINDING   377   377        ATP (By similarity). 
MOD_RES   500   500        Phosphotyrosine; by autocatalysis (By similarity). 
Sequence information
Length: 609 AA [This is the length of the unprocessed precursor] Molecular weight: 68769 Da [This is the MW of the unprocessed precursor] CRC64: 53D4919757CF73A3 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
AARADGTMGF SSELCSPQGH GAEQQMQEAE LRLLEGMRKW MAQRVKSDRE YAGLLHHMSL 

        70         80         90        100        110        120 
QDGGGRGTGP YSPISQSWAE ITSQTEGLSR LLRQHAEDLN SGPLSKLGLL IRERQQLRKT 

       130        140        150        160        170        180 
YSEQWQQLQQ ELTKTHNQDI EKLKSQYRAL ARDSAQARRK YQEASKDKDR DKAKLEQLGP 

       190        200        210        220        230        240 
GEPPPVLLLQ DDRHSTSSSE QEREGGRTPT LEILKSHISG IFRPKFSLPP PLQLVPEVQK 

       250        260        270        280        290        300 
PLHEQLWYHG ALPRAEVAEL LTHSGDFLVR ESQGKQEYVL SVLWDGQPRH FIIQSADNLY 

       310        320        330        340        350        360 
RPEGDGFASI PLLVDHLLRS QQPLTKKSGI VLNRAVPKDK WVLNHEDLVL GEQIGRGNFG 

       370        380        390        400        410        420 
EVFSGRLRAD NTLVAVKSCR ETLPPDIKAK FLQEAKILKQ YSHPNIVRLI GVCTQKQPIY 

       430        440        450        460        470        480 
IVMELVQGGD FLTFLRTEGA RLRMKTLLQM VGDAAAGMEY LESKCCIHRD LAARNCLVTE 

       490        500        510        520        530        540 
KNVLKISDFG MSREAADGIY AASGGLRQVP VKWTAPEALN YGRYSSESDV WSFGILLWET 

       550        560        570        580        590        600 
FSLGASPYPN LSNQQTREFV EKGGRLPCPE LCPDAVFRLM EQCWAYEPGQ RPSFSAIYQE 


LQSIRKRHR
P00542 in FASTA format

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