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UniProtKB/Swiss-Prot entry P00541

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FPS_AVISP
Primary accession number P00541
Secondary accession numbers None
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on July 21, 1986 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 72)
Name and origin of the protein
Protein name Tyrosine-protein kinase transforming protein Fps
Synonym EC 2.7.10.2
Gene name
Name: V-FPS
From
Avian sarcoma virus (strain PRCII) [TaxID: 11880] 
Taxonomy Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Alpharetrovirus.
Virus host Galliformes [TaxID: 8976]
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC RNA].
PubMed=6321783 [NCBI, ExPASy, EBI, Israel, Japan]
Huang C.-C., Hammond C., Bishop J.M.;
"Nucleotide sequence of v-fps in the PRCII strain of avian sarcoma virus.";
J. Virol. 50:125-131(1984).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
K01690; AAA42415.1; -; Genomic_RNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A00650; TVFVFP.
3D structure databases
HSSP P11362; 1FGK. [HSSP ENTRY / PDB]
ModBase P00541.
Ontologies
GO
GO:0004715; Molecular function: non-membrane spanning protein tyrosine kinase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR001060; Cdc15_Fes_CIP4.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR000980; SH2.
IPR001245; Tyr_pkinase.
IPR008266; Tyr_pkinase_AS.
Graphical view of domain structure.
Gene3D G3DSA:3.30.505.10; SH2; 1.
Pfam PF00611; FCH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
Pfam graphical view of domain structure.
PRINTS PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
ProDom PD000001; Prot_kinase; 1.
PD000093; SH2; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00055; FCH; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 1.
SMART graphical view of domain structure.
PROSITE PS50133; FCH; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P00541.
ProtoNet P00541.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Kinase; Nucleotide-binding; Oncogene; Phosphoprotein; SH2 domain; Transferase; Tyrosine-protein kinase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   533  533     Tyrosine-protein kinase transforming protein Fps. PRO_0000088094
DOMAIN   50   127  78     FCH. 
DOMAIN   171   260  90     SH2. 
DOMAIN   272   525  254     Protein kinase. 
NP_BIND   278   286  9     ATP (By similarity). 
ACT_SITE   394   394        Proton acceptor (By similarity). 
BINDING   301   301        ATP (By similarity). 
MOD_RES   424   424        Phosphotyrosine; by autocatalysis (By similarity). 
Sequence information
Length: 533 AA [This is the length of the unprocessed precursor] Molecular weight: 60506 Da [This is the MW of the unprocessed precursor] CRC64: 2F765877C2522D8A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
ASGQLHRPQP QEHTSTSAAA GTWRHTQASE SRHRLPHCSA APSHQDHSAM GFGPELWCPK 

        70         80         90        100        110        120 
GHSELLRLQD SELRLLELMK KWMSERAKSD REYAGMLHHM FSQLGSEEPP PALPLQEDRQ 

       130        140        150        160        170        180 
SVCSTDQERS GVTALETIKN HISGIFSPRF SLPPPVPLIP EVQKPLCQQA WYHGAIPRSE 

       190        200        210        220        230        240 
VQELLKCSGD FLVRESQGKQ EYVLSVLWDG QPRHFIIQAA DNLYRLEGDG FPTIPLLIDH 

       250        260        270        280        290        300 
LLQSQQPITR KSGIVLTRAV LKDKWVLNHE DVLLGERIGR GNFGEVFSGR LRADNTPVAV 

       310        320        330        340        350        360 
KSCRETLPPE LKAKFLQEAR ILKQYNHPNI VRLIGVCTQK QPIYIVMELV QGGDFLSFLR 

       370        380        390        400        410        420 
SKGPHLKMKE LIKMMENAAA GMEYLESKHC IHRDLAARNC LVTEKNTLKI SDFGMSRQEE 

       430        440        450        460        470        480 
DGVYASTGGM KQIPVKWTAP EALNYGRYSS ESDVWSFGIL LWEAFSLGAV PYANLSNQQT 

       490        500        510        520        530 
REAIEQGVRL EPPEQCPEDV YRLMQRCWEY DPRRRPSFGA VHQDLIAIRK RHR
P00541 in FASTA format

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