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UniProtKB/Swiss-Prot entry P00530

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FPS_FUJSV
Primary accession number P00530
Secondary accession numbers None
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on July 21, 1986 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 76)
Name and origin of the protein
Protein name Tyrosine-protein kinase transforming protein FPS
Synonym EC 2.7.10.2
Gene name
Name: V-FPS
From
Fujinami sarcoma virus [TaxID: 11885] 
Taxonomy Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Alpharetrovirus.
Virus host Gallus gallus (Chicken) [TaxID: 9031]
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC RNA].
DOI=10.1016/0092-8674(82)90283-5; PubMed=6291784 [NCBI, ExPASy, EBI, Israel, Japan]
Shibuya M., Hanafusa H.;
"Nucleotide sequence of Fujinami sarcoma virus: evolutionary relationship of its transforming gene with transforming genes of other sarcoma viruses.";
Cell 30:787-795(1982).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC RNA] (CLONE TS).
DOI=10.1016/0042-6822(86)90172-8; PubMed=2877522 [NCBI, ExPASy, EBI, Israel, Japan]
Chen L.H., Hatada E., Wheatley W., Lee W.H.;
"Single amino acid substitution, from Glu1025 to Asp, of the fps oncogenic protein causes temperature sensitivity in transformation and kinase activity.";
Virology 155:106-119(1986).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
J02194; AAA42402.1; ALT_INIT; Genomic_RNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M14930; AAA42403.1; -; Genomic_RNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A00636; TVFVF.
A26898; TVFVFS.
RefSeq NP_955606.1; -.
3D structure databases
HSSP P11362; 1FGK. [HSSP ENTRY / PDB]
ModBase P00530.
Ontologies
GO
GO:0004715; Molecular function: non-membrane spanning protein tyrosine kinase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR001060; Cdc15_Fes_CIP4.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR000980; SH2.
IPR001245; Tyr_pkinase.
IPR008266; Tyr_pkinase_AS.
IPR016250; TyrPK_fps.
Graphical view of domain structure.
Gene3D G3DSA:3.30.505.10; SH2; 1.
Pfam PF00611; FCH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000632; TyrPK_fps; 1.
PRINTS PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
ProDom PD000001; Prot_kinase; 1.
PD000093; SH2; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00055; FCH; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 1.
SMART graphical view of domain structure.
PROSITE PS50133; FCH; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P00530.
ProtoNet P00530.
Genome annotation databases
GeneID 1491921; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Kinase; Nucleotide-binding; Oncogene; Phosphoprotein; SH2 domain; Transferase; Tyrosine-protein kinase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   873  873     Tyrosine-protein kinase transforming protein FPS. PRO_0000088096
DOMAIN   50   122  73     FCH. 
DOMAIN   511   600  90     SH2. 
DOMAIN   612   865  254     Protein kinase. 
NP_BIND   618   626  9     ATP (By similarity). 
ACT_SITE   734   734        Proton acceptor (By similarity). 
BINDING   641   641        ATP (By similarity). 
MOD_RES   764   764        Phosphotyrosine; by autocatalysis (By similarity). 
VARIANT   63    63  1     T -> S (in clone TS). 
VARIANT   251   251  1     H -> R (in clone TS). 
VARIANT   300   300  1     K -> E (in clone TS). 
VARIANT   343   343  1     N -> S (in clone TS). 
VARIANT   438   438  1     A -> T (in clone TS). 
VARIANT   447   447  1     E -> D (in clone TS). 
VARIANT   463   463  1     R -> C (in clone TS). 
VARIANT   716   716  1     E -> D (in clone TS). 
Sequence information
Length: 873 AA [This is the length of the unprocessed precursor] Molecular weight: 99536 Da [This is the MW of the unprocessed precursor] CRC64: 1D774D48B18466B6 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
ASGQLHRPQP QEHTSTSAAA GTWRLTQASE SRHRLPHCSA APSHQDHSAM GFGPELWCPK 

        70         80         90        100        110        120 
GHTELLRLQD SELRLLELMK KWMSQRAKSD REYAGMLHHM FSQLEKQEGL GHLRATDHSS 

       130        140        150        160        170        180 
QIGESWWVLA SQTETLSQTL RRHAEELAAG PLAKLSILIR DKQQLRKVFS EQWQQLSQEY 

       190        200        210        220        230        240 
AWTTQQEVEK LKAQYRSLVR DSTQAKRKYQ EASKDKEREK AKEKYVRSLS KLYALHNQYV 

       250        260        270        280        290        300 
LAVQAAALHH HHHYQRALPT LHESLYSLQQ EMVLVLKEIL GEYCSITSLV QEDVLAIHQK 

       310        320        330        340        350        360 
VAHAVEMIDP ATEYSSFVQC HRYDSEVPPA VTFDESLLEE AENLEPGELQ LNELTIESVQ 

       370        380        390        400        410        420 
HSLTSIEEEL LASRKAVSSK EQRVWELQVE LRGEELALSP GERVHLLGKR QGLREAQQQL 

       430        440        450        460        470        480 
QGLVCAQAKL QAQRDMLANK LAELGSEEPP PALPLQEDRQ SARSTDQERS GVTALKTIKN 

       490        500        510        520        530        540 
HISGIFSPRF SLPPPVPLIP EVQKPLCQQA WYHGAIPRSE VQELLKYSGD FLVRESQGKQ 

       550        560        570        580        590        600 
EYVLSVLWDG QPRHFIIQAA DNLYRLEDDG LPTIPLLIDH LLQSQRPITR KSGIVLTRAV 

       610        620        630        640        650        660 
LKDKWVLNHE DVLLGERIGR GNFGEVFSGR LRADNTPVAV KSCRETLPPE LKAKFLQEAR 

       670        680        690        700        710        720 
ILKQCNHPNI VRLIGVCTQK QPIYIVMELV QGGDFLSFLR SKGPRLKMKK LIKMMENAAA 

       730        740        750        760        770        780 
GMEYLESKHC IHRDLAARNC LVTEKNTLKI SDFGMSRQEE DGVYASTGGM KQIPVKWTAP 

       790        800        810        820        830        840 
EALNYGWYSS ESDVWSFGIL LWEAFSLGAV PYANLSNQQT REAIEQGVRL EPPEQCPEDV 

       850        860        870 
YRLMQRCWEY DPHRRPSFGA VHQDLIAIRK RHR
P00530 in FASTA format

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