[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM I).
TISSUE=Testis;
PubMed=3317402 [NCBI, ExPASy, EBI, Israel, Japan]
Oppi C.,
Shore S.K.,
Reddy E.P.;
"Nucleotide sequence of testis-derived c-abl cDNAs: implications for testis-specific transcription and abl oncogene activation.";
Proc. Natl. Acad. Sci. U.S.A. 84:8200-8204(1987).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM I).
STRAIN=ICR;
TISSUE=Embryo;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P.,
Kasukawa T.,
Katayama S.,
Gough J.,
Frith M.C.,
Maeda N.,
Oyama R.,
Ravasi T.,
Lenhard B.,
Wells C.,
Kodzius R.,
Shimokawa K.,
Bajic V.B.,
Brenner S.E.,
Batalov S.,
Forrest A.R.,
Zavolan M.,
Davis M.J.,
Wilming L.G., ![]()
Aidinis V.,
Allen J.E.,
Ambesi-Impiombato A.,
Apweiler R.,
Aturaliya R.N.,
Bailey T.L.,
Bansal M.,
Baxter L.,
Beisel K.W.,
Bersano T.,
Bono H.,
Chalk A.M.,
Chiu K.P.,
Choudhary V.,
Christoffels A.,
Clutterbuck D.R.,
Crowe M.L.,
Dalla E.,
Dalrymple B.P.,
de Bono B.,
Della Gatta G.,
di Bernardo D.,
Down T.,
Engstrom P.,
Fagiolini M.,
Faulkner G.,
Fletcher C.F.,
Fukushima T.,
Furuno M.,
Futaki S.,
Gariboldi M.,
Georgii-Hemming P.,
Gingeras T.R.,
Gojobori T.,
Green R.E.,
Gustincich S.,
Harbers M.,
Hayashi Y.,
Hensch T.K.,
Hirokawa N.,
Hill D.,
Huminiecki L.,
Iacono M.,
Ikeo K.,
Iwama A.,
Ishikawa T.,
Jakt M.,
Kanapin A.,
Katoh M.,
Kawasawa Y.,
Kelso J.,
Kitamura H.,
Kitano H.,
Kollias G.,
Krishnan S.P.,
Kruger A.,
Kummerfeld S.K.,
Kurochkin I.V.,
Lareau L.F.,
Lazarevic D.,
Lipovich L.,
Liu J.,
Liuni S.,
McWilliam S.,
Madan Babu M.,
Madera M.,
Marchionni L.,
Matsuda H.,
Matsuzawa S.,
Miki H.,
Mignone F.,
Miyake S.,
Morris K.,
Mottagui-Tabar S.,
Mulder N.,
Nakano N.,
Nakauchi H.,
Ng P.,
Nilsson R.,
Nishiguchi S.,
Nishikawa S.,
Nori F.,
Ohara O.,
Okazaki Y.,
Orlando V.,
Pang K.C.,
Pavan W.J.,
Pavesi G.,
Pesole G.,
Petrovsky N.,
Piazza S.,
Reed J.,
Reid J.F.,
Ring B.Z.,
Ringwald M.,
Rost B.,
Ruan Y.,
Salzberg S.L.,
Sandelin A.,
Schneider C.,
Schoenbach C.,
Sekiguchi K.,
Semple C.A.,
Seno S.,
Sessa L.,
Sheng Y.,
Shibata Y.,
Shimada H.,
Shimada K.,
Silva D.,
Sinclair B.,
Sperling S.,
Stupka E.,
Sugiura K.,
Sultana R.,
Takenaka Y.,
Taki K.,
Tammoja K.,
Tan S.L.,
Tang S.,
Taylor M.S.,
Tegner J.,
Teichmann S.A.,
Ueda H.R.,
van Nimwegen E.,
Verardo R.,
Wei C.L.,
Yagi K.,
Yamanishi H.,
Zabarovsky E.,
Zhu S.,
Zimmer A.,
Hide W.,
Bult C.,
Grimmond S.M.,
Teasdale R.D.,
Liu E.T.,
Brusic V.,
Quackenbush J.,
Wahlestedt C.,
Mattick J.S.,
Hume D.A.,
Kai C.,
Sasaki D.,
Tomaru Y.,
Fukuda S.,
Kanamori-Katayama M.,
Suzuki M.,
Aoki J.,
Arakawa T.,
Iida J.,
Imamura K.,
Itoh M.,
Kato T.,
Kawaji H.,
Kawagashira N.,
Kawashima T.,
Kojima M.,
Kondo S.,
Konno H.,
Nakano K.,
Ninomiya N.,
Nishio T.,
Okada M.,
Plessy C.,
Shibata K.,
Shiraki T.,
Suzuki S.,
Tagami M.,
Waki K.,
Watahiki A.,
Okamura-Oho Y.,
Suzuki H.,
Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM IV).
STRAIN=C57BL/6;
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[4]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-187 (ISOFORMS I; II; III AND IV).
DOI=10.1006/geno.1995.1008; PubMed=7665185 [NCBI, ExPASy, EBI, Israel, Japan]
Chissoe S.L.,
Bodenteich A.,
Wang Y.-F.,
Wang Y.-P.,
Burian D.,
Clifton S.W.,
Crabtree J.,
Freeman A.,
Iyer K.,
Jian L.,
Ma Y.,
McLaury H.-J.,
Pan H.-Q.,
Sarhan O.H.,
Toth S.,
Wang Z.,
Zhang G.,
Heisterkamp N.,
Groffen J.,
Roe B.A.;
"Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation.";
Genomics 27:67-82(1995).
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[5]
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NUCLEOTIDE SEQUENCE OF 85-182.
DOI=10.1016/0092-8674(84)90228-9; PubMed=6319018 [NCBI, ExPASy, EBI, Israel, Japan]
Wang J.Y.J.,
Ledley F.,
Goff S.,
Lee R.,
Groner Y.,
Baltimore D.;
"The mouse c-abl locus: molecular cloning and characterization.";
Cell 36:349-356(1984).
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[6]
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ALTERNATIVE SPLICING.
PubMed=3283651 [NCBI, ExPASy, EBI, Israel, Japan]
Bernards A.,
Paskind M.,
Baltimore D.;
"Four murine c-abl mRNAs arise by usage of two transcriptional promoters and alternative splicing.";
Oncogene 2:297-304(1988).
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[7]
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FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCALIZATION, PHOSPHORYLATION AT SER-446, AND MUTAGENESIS OF SER-446.
DOI=10.1038/386732a0; PubMed=9109492 [NCBI, ExPASy, EBI, Israel, Japan]
Kharbanda S.,
Pandey P.,
Jin S.,
Inoue S.,
Bharti A.,
Yuan Z.-M.,
Weichselbaum R.,
Weaver D.,
Kufe D.;
"Functional interaction between DNA-PK and c-Abl in response to DNA damage.";
Nature 386:732-735(1997).
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[8]
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SUBCELLULAR LOCALIZATION.
DOI=10.1073/pnas.95.13.7457; PubMed=9636171 [NCBI, ExPASy, EBI, Israel, Japan]
Taagepera S.,
McDonald D.,
Loeb J.E.,
Whitaker L.L.,
McElroy A.K.,
Wang J.Y.,
Hope T.J.;
"Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase.";
Proc. Natl. Acad. Sci. U.S.A. 95:7457-7462(1998).
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[9]
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IDENTIFICATION IN A TRIMOLECULAR COMPLEX WITH CDK5 AND CABLES1, AND INTERACTION WITH CABLES1.
TISSUE=Brain;
DOI=10.1016/S0896-6273(00)81200-3; PubMed=10896159 [NCBI, ExPASy, EBI, Israel, Japan]
Zukerberg L.R.,
Patrick G.N.,
Nikolic M.,
Humbert S.,
Wu C.-L.,
Lanier L.M.,
Gertler F.B.,
Vidal M.,
Van Etten R.A.,
Tsai L.-H.;
"Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth.";
Neuron 26:633-646(2000).
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[10]
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INTERACTION WITH PSTPIP1.
DOI=10.1016/S1097-2765(00)00138-6; PubMed=11163214 [NCBI, ExPASy, EBI, Israel, Japan]
Cong F.,
Spencer S.,
Cote J.F.,
Wu Y.,
Tremblay M.L.,
Lasky L.A.,
Goff S.P.;
"Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation.";
Mol. Cell 6:1413-1423(2000).
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[11]
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INTERACTION WITH CRK, AND FUNCTION.
DOI=10.1074/jbc.M100095200; PubMed=11279004 [NCBI, ExPASy, EBI, Israel, Japan]
Kain K.H.,
Klemke R.L.;
"Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes.";
J. Biol. Chem. 276:16185-16192(2001).
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[12]
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INTERACTION WITH ZDHHC16.
DOI=10.1074/jbc.M202388200; PubMed=12021275 [NCBI, ExPASy, EBI, Israel, Japan]
Li B.,
Cong F.,
Tan C.P.,
Wang S.X.,
Goff S.P.;
"Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has pro-apoptotic activity.";
J. Biol. Chem. 277:28870-28876(2002).
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[13]
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FUNCTION, ENZYME REGULATION, INTERACTION WITH CRK, AUTOPHOSPHORYLATION AT TYR-226 AND TYR-393, AND MUTAGENESIS OF TYR-226; LYS-271 AND TYR-393.
DOI=10.1128/MCB.23.11.3884-3896.2003; PubMed=12748290 [NCBI, ExPASy, EBI, Israel, Japan]
Tanis K.Q.,
Veach D.,
Duewel H.S.,
Bornmann W.G.,
Koleske A.J.;
"Two distinct phosphorylation pathways have additive effects on Abl family kinase activation.";
Mol. Cell. Biol. 23:3884-3896(2003).
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[14]
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X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 61-121.
DOI=10.1038/nsb0894-546; PubMed=7664083 [NCBI, ExPASy, EBI, Israel, Japan]
Musacchio A.,
Saraste M.,
Wilmanns M.;
"High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides.";
Nat. Struct. Biol. 1:546-551(1994).
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[15]
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X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 229-515.
DOI=10.1126/science.289.5486.1938; PubMed=10988075 [NCBI, ExPASy, EBI, Israel, Japan]
Schindler T.,
Bornmann W.,
Pellicena P.,
Miller W.T.,
Clarkson B.,
Kuriyan J.;
"Structural mechanism for STI-571 inhibition of abelson tyrosine kinase.";
Science 289:1938-1942(2000).
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