ID 6PGD_ECOLI Reviewed; 468 AA. AC P00350; P78080; Q47571; Q59366; Q59402; Q59411; Q59412; Q59413; AC Q59414; Q59416; Q79DT3; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 2. DT 02-SEP-2008, entry version 80. DE RecName: Full=6-phosphogluconate dehydrogenase, decarboxylating; DE EC=1.1.1.44; GN Name=gnd; OrderedLocusNames=b2029, JW2011; OS Escherichia coli (strain K12). OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=83333; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=84237540; PubMed=6329905; DOI=10.1016/0378-1119(84)90070-2; RA Nasoff M.S., Baker H.V. II, Wolf R.E. Jr.; RT "DNA sequence of the Escherichia coli gene, gnd, for 6- RT phosphogluconate dehydrogenase."; RL Gene 27:253-264(1984). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=ECOR 10; RX MEDLINE=91267957; PubMed=2050640; RA Bisercic M., Feutrier J.Y., Reeves P.R.; RT "Nucleotide sequences of the gnd genes from nine natural isolates of RT Escherichia coli: evidence of intragenic recombination as a RT contributing factor in the evolution of the polymorphic gnd locus."; RL J. Bacteriol. 173:3894-3900(1991). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=ECOR 45, ECOR 65, ECOR 67, ECOR 68, ECOR 69, and ECOR 70; RX MEDLINE=92041624; PubMed=1938920; RA Dykhuizen D.E., Green L.; RT "Recombination in Escherichia coli and the definition of biological RT species."; RL J. Bacteriol. 173:7257-7268(1991). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; RX MEDLINE=97251358; PubMed=9097040; DOI=10.1093/dnares/3.6.379; RA Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., RA Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., RA Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y., RA Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y., RA Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., RA Yamamoto Y., Horiuchi T.; RT "A 460-kb DNA sequence of the Escherichia coli K-12 genome RT corresponding to the 40.1-50.0 min region on the linkage map."; RL DNA Res. 3:379-392(1996). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / MG1655 / ATCC 47076; RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453; RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., RA Mau B., Shao Y.; RT "The complete genome sequence of Escherichia coli K-12."; RL Science 277:1453-1474(1997). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; RX PubMed=16738553; DOI=10.1038/msb4100049; RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.; RT "Highly accurate genome sequences of Escherichia coli K-12 strains RT MG1655 and W3110."; RL Mol. Syst. Biol. 2:E1-E5(2006). RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-125. RX MEDLINE=89126937; PubMed=2464736; RA Miller R.D., Dykhuizen D.E., Hartl D.L.; RT "Fitness effects of a deletion mutation increasing transcription of RT the 6-phosphogluconate dehydrogenase gene in Escherichia coli."; RL Mol. Biol. Evol. 5:691-703(1988). RN [8] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-125. RX MEDLINE=88086897; PubMed=3275621; RA Barcak G.J., Wolf R.E. Jr.; RT "Comparative nucleotide sequence analysis of growth-rate-regulated gnd RT alleles from natural isolates of Escherichia coli and from Salmonella RT typhimurium LT-2."; RL J. Bacteriol. 170:372-379(1988). RN [9] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-125. RC STRAIN=O7:K1 / VW187; RX MEDLINE=93106949; PubMed=7677991; RA Marolda C.L., Valvano M.A.; RT "Identification, expression, and DNA sequence of the GDP-mannose RT biosynthesis genes encoded by the O7 rfb gene cluster of strain VW187 RT (Escherichia coli O7:K1)."; RL J. Bacteriol. 175:148-158(1993). CC -!- CATALYTIC ACTIVITY: 6-phospho-D-gluconate + NADP(+) = D-ribulose CC 5-phosphate + CO(2) + NADPH. CC -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D- CC ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): CC step 3/3. CC -!- INTERACTION: CC P18843:nadE; NbExp=1; IntAct=EBI-907049, EBI-548960; CC -!- SIMILARITY: Belongs to the 6-phosphogluconate dehydrogenase CC family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; K02072; AAA23918.1; -; Genomic_DNA. DR EMBL; M63821; AAA24488.1; -; Genomic_DNA. DR EMBL; M64326; AAA24204.1; -; Genomic_DNA. DR EMBL; M64327; AAA24205.1; -; Genomic_DNA. DR EMBL; M64328; AAA24206.1; -; Genomic_DNA. DR EMBL; M64329; AAA24207.1; -; Genomic_DNA. DR EMBL; M64330; AAA24208.1; -; Genomic_DNA. DR EMBL; M64331; AAA24209.1; -; Genomic_DNA. DR EMBL; U00096; AAC75090.1; -; Genomic_DNA. DR EMBL; AP009048; BAA15869.1; -; Genomic_DNA. DR EMBL; M23181; AAA23924.1; -; Genomic_DNA. DR EMBL; M18956; AAA23919.1; -; Genomic_DNA. DR EMBL; M18957; AAA23920.1; -; Genomic_DNA. DR EMBL; M18960; AAA23922.1; -; Genomic_DNA. DR EMBL; AF125322; AAC27540.1; -; Genomic_DNA. DR PIR; D64968; DEECGC. DR PIR; I62463; I62463. DR PIR; I62465; I62465. DR RefSeq; AP_002630.1; -. DR RefSeq; NP_416533.1; -. DR HSSP; P00349; 2PGD. DR IntAct; P00350; -. DR ECO2DBASE; C042.6; 6TH EDITION. DR GeneID; 946554; -. DR GenomeReviews; U00096_GR; b2029. DR GenomeReviews; AP009048_GR; JW2011. DR KEGG; ecj:JW2011; -. DR KEGG; eco:b2029; -. DR EchoBASE; EB0406; -. DR EcoGene; EG10411; gnd. DR BioCyc; EcoCyc:6PGLUCONDEHYDROG-MON; -. DR BioCyc; MetaCyc:6PGLUCONDEHYDROG-MON; -. DR GO; GO:0005515; F:protein binding; IPI:IntAct. DR InterPro; IPR006183; 6-phosphogluconate_DHase. DR InterPro; IPR006114; 6PGDH_C. DR InterPro; IPR006113; 6PGDH_decarbox. DR InterPro; IPR006115; 6PGDH_NAD-bd. DR InterPro; IPR006184; 6PGdom_BS. DR InterPro; IPR013328; DHase_multihelical. DR InterPro; IPR012284; Fibritin/6PGD_C-extension. DR InterPro; IPR016040; NAD(P)-bd. DR Gene3D; G3DSA:1.20.5.320; Fibritin/6PGD_C-extension; 1. DR Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1. DR Gene3D; G3DSA:1.10.1040.10; Opine_DH; 1. DR Pfam; PF00393; 6PGD; 1. DR Pfam; PF03446; NAD_binding_2; 1. DR PRINTS; PR00076; 6PGDHDRGNASE. DR TIGRFAMs; TIGR00873; gnd; 1. DR PROSITE; PS00461; 6PGD; 1. PE 1: Evidence at protein level; KW Complete proteome; Gluconate utilization; NADP; Oxidoreductase; KW Pentose shunt. FT CHAIN 1 468 6-phosphogluconate dehydrogenase, FT decarboxylating. FT /FTId=PRO_0000090037. FT VARIANT 2 2 S -> L (in strain: ECOR 70). FT VARIANT 32 32 F -> Y (in strain: ECOR 70). FT VARIANT 39 39 T -> Q (in strain: O7:K1 / VW187). FT VARIANT 52 52 V -> D (in strain: ECOR 10). FT VARIANT 55 55 Y -> F (in strain: ECOR 10). FT VARIANT 102 102 N -> K (in strain: ECOR 65). FT VARIANT 117 117 A -> S (in strain: ECOR 70). FT VARIANT 123 125 IGT -> YRY (in strain: O7:K1 / VW187). FT VARIANT 170 170 V -> F (in strain: ECOR 10). FT VARIANT 175 175 A -> S (in strain: ECOR 45). FT VARIANT 209 209 N -> S (in strain: ECOR 68). FT VARIANT 211 211 T -> S (in strain: ECOR 10 and ECOR 69). FT VARIANT 216 216 A -> T (in strain: ECOR 67). FT VARIANT 294 294 D -> E (in strain: ECOR 70). FT VARIANT 308 308 A -> G (in strain: ECOR 68). FT VARIANT 313 313 D -> N (in strain: ECOR 67). FT VARIANT 315 315 A -> G (in strain: ECOR 70). FT VARIANT 325 325 L -> Q (in strain: ECOR 69). FT VARIANT 330 330 I -> S (in strain: ECOR 10). FT VARIANT 350 350 D -> A (in strain: ECOR 10 and ECOR 69). FT VARIANT 369 369 Q -> R (in strain: ECOR 10). FT VARIANT 422 422 S -> A (in strain: ECOR 10, ECOR 65, ECOR FT 68, ECOR 69 and ECOR 70). FT CONFLICT 306 306 P -> R (in Ref. 1; AAA23918). SQ SEQUENCE 468 AA; 51481 MW; 62A32C84DC596D86 CRC64; MSKQQIGVVG MAVMGRNLAL NIESRGYTVS IFNRSREKTE EVIAENPGKK LVPYYTVKEF VESLETPRRI LLMVKAGAGT DAAIDSLKPY LDKGDIIIDG GNTFFQDTIR RNRELSAEGF NFIGTGVSGG EEGALKGPSI MPGGQKEAYE LVAPILTKIA AVAEDGEPCV TYIGADGAGH YVKMVHNGIE YGDMQLIAEA YSLLKGGLNL TNEELAQTFT EWNNGELSSY LIDITKDIFT KKDEDGNYLV DVILDEAANK GTGKWTSQSA LDLGEPLSLI TESVFARYIS SLKDQRVAAS KVLSGPQAQP AGDKAEFIEK VRRALYLGKI VSYAQGFSQL RAASEEYNWD LNYGEIAKIF RAGCIIRAQF LQKITDAYAE NPQIANLLLA PYFKQIADDY QQALRDVVAY AVQNGIPVPT FSAAVAYYDS YRAAVLPANL IQAQRDYFGA HTYKRIDKEG VFHTEWLD //