ID   CYC2_MOUSE              Reviewed;         105 AA.
AC   P00015;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   22-JUL-2008, entry version 83.
DE   RecName: Full=Cytochrome c, testis-specific;
GN   Name=Cyct;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=88198250; PubMed=2834389;
RA   Virbasius J.V., Scarpulla R.C.;
RT   "Structure and expression of rodent genes encoding the testis-specific
RT   cytochrome c. Differences in gene structure and evolution between
RT   somatic and testicular variants.";
RL   J. Biol. Chem. 263:6791-6796(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   PRELIMINARY PROTEIN SEQUENCE OF 2-105.
RC   STRAIN=BALB/c;
RX   MEDLINE=76022386; PubMed=240690;
RA   Hennig B.;
RT   "Change of cytochrome c structure during development of the mouse.";
RL   Eur. J. Biochem. 55:167-183(1975).
CC   -!- FUNCTION: Electron carrier protein. The oxidized form of the
CC       cytochrome c heme group can accept an electron from the heme group
CC       of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c
CC       then transfers this electron to the cytochrome oxidase complex,
CC       the final protein carrier in the mitochondrial electron-transport
CC       chain.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix.
CC   -!- TISSUE SPECIFICITY: This is one of two isocytochromes C found in
CC       the testis. The other is identical with the form found in other
CC       mouse tissues. These cytochromes are assumed to be located in the
CC       sperm.
CC   -!- PTM: Binds 1 heme group per subunit.
CC   -!- SIMILARITY: Belongs to the cytochrome c family.
CC   -!- WEB RESOURCE: Name=Protein Spotlight; Note=Life shuttle - Issue 76
CC       of November 2006;
CC       URL="http://www.expasy.org/spotlight/back_issues/sptlt076.shtml";
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DR   EMBL; M20625; AAA37501.1; -; mRNA.
DR   EMBL; X55771; CAA39293.1; -; mRNA.
DR   EMBL; AK005582; BAB24136.1; -; mRNA.
DR   EMBL; AK018833; BAB31455.1; -; mRNA.
DR   EMBL; AK018851; BAB31464.1; -; mRNA.
DR   PIR; B28160; CCMST.
DR   RefSeq; NP_034119.1; -.
DR   UniGene; Mm.4872; -.
DR   PDB; 2AIU; X-ray; 1.60 A; A=1-105.
DR   PDBsum; 2AIU; -.
DR   Ensembl; ENSMUSG00000056436; Mus musculus.
DR   GeneID; 13067; -.
DR   KEGG; mmu:13067; -.
DR   NMPDR; fig|10090.3.peg.6178; -.
DR   MGI; MGI:88579; Cyct.
DR   HOGENOM; P00015; -.
DR   HOVERGEN; P00015; -.
DR   ArrayExpress; P00015; -.
DR   CleanEx; MM_CYCT; -.
DR   GermOnline; ENSMUSG00000056436; Mus musculus.
DR   GO; GO:0020037; F:heme binding; IDA:MGI.
DR   GO; GO:0006915; P:apoptosis; IDA:MGI.
DR   GO; GO:0042743; P:hydrogen peroxide metabolic process; IDA:MGI.
DR   InterPro; IPR009056; Cyt_c_monohaem.
DR   InterPro; IPR003088; Cyt_CI.
DR   InterPro; IPR002327; Cyt_CIAB.
DR   Gene3D; G3DSA:1.10.760.10; Cytochrome_c_R; 1.
DR   PANTHER; PTHR11961; Cyt_CIAB; 1.
DR   Pfam; PF00034; Cytochrom_C; 1.
DR   PRINTS; PR00604; CYTCHRMECIAB.
DR   ProDom; PD000375; Cyt_CIAB; 1.
DR   PROSITE; PS51007; CYTC; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Acetylation; Direct protein sequencing;
KW   Electron transport; Heme; Iron; Metal-binding; Mitochondrion;
KW   Respiratory chain; Transport.
FT   INIT_MET      1      1       Removed.
FT   CHAIN         2    105       Cytochrome c, testis-specific.
FT                                /FTId=PRO_0000108226.
FT   METAL        19     19       Iron (heme axial ligand).
FT   METAL        81     81       Iron (heme axial ligand).
FT   BINDING      15     15       Heme (covalent).
FT   BINDING      18     18       Heme (covalent).
FT   MOD_RES       2      2       N-acetylglycine.
FT   HELIX         4     14
FT   TURN         15     18
FT   STRAND       39     42
FT   HELIX        51     55
FT   HELIX        62     70
FT   HELIX        72     75
FT   HELIX        89    104
SQ   SEQUENCE   105 AA;  11714 MW;  00C275FC70B5AAF9 CRC64;
     MGDAEAGKKI FVQKCAQCHT VEKGGKHKTG PNLWGLFGRK TGQAPGFSYT DANKNKGVIW
     SEETLMEYLE NPKKYIPGTK MIFAGIKKKS EREDLIKYLK QATSS
//