NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Japanese white;
TISSUE=Bone;
PubMed=9753427 [NCBI, ExPASy, EBI, Israel, Japan]
Kobori M., Ikeda Y., Nara H., Kato M., Kumegawa M., Nojima H., Kawashima H.;
"Large scale isolation of osteoclast-specific genes by an improved method involving the preparation of a subtracted cDNA library.";
Genes Cells 3:459-475(1998).

Comments

CATALYTIC ACTIVITY: A phosphate monoester + H₂O = an alcohol + phosphate.
COFACTOR: Binds 2 iron ions (By similarity).
SUBUNIT: Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s) (By similarity).
SUBCELLULAR LOCATION: Lysosome (By similarity).

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AB009340; BAA75919.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001075457.1; -.

UniGene

Ocu.1775

3D structure databases

HSSP

P09889; 1UTE. [HSSP ENTRY / PDB]

SMR

O97860; 19-324.

ModBase

O97860.

Ontologies

GO:0005764;	Cellular component: lysosome (inferred from electronic annotation from UniProtKB-KW).
GO:0003993;	Molecular function: acid phosphatase activity (inferred from electronic annotation from EC).
GO:0005506;	Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR004843; M-pesterase.
Graphical view of domain structure.

Pfam

PF00149; Metallophos; 1.
Pfam graphical view of domain structure.

Genome annotation databases

GeneID

100008599; -.

Phylogenomic databases

HOVERGEN

O97860; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Glycoprotein; Hydrolase; Iron; Lysosome; Signal.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 21`	`21`	`Potential.`
`CHAIN`	`22 325`	`304`	`Tartrate-resistant acid phosphatase type 5.`	`PRO_0000023983`
`CARBOHYD`	`116 116`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`147 147`		`N-linked (GlcNAc...) (Potential).`

Sequence information

Length: 325 AA [This is the length of the unprocessed precursor]

Molecular weight: 36624 Da [This is the MW of the unprocessed precursor]

CRC64: 9AE28F2CDDCB5C7B [This is a checksum on the sequence]

        10         20         30         40         50         60 
MDTWTLLLVL HTSLLLPWAE GATPTLRFVA VGDWGGVPNA PFHTAREMAN AKQIGKVVQM 

        70         80         90        100        110        120 
LGAHFILSLG DNFYFSGVQS VSDKRFQETF EDVFSDRSLQ NVPWYVLAGN HDHIGNVSAQ 

       130        140        150        160        170        180 
IAYSKVSKRW NFPSPFYRLR FRIPRTNVSV AIYMLDTVTL CGNSNDFLSQ QPERPRNLEL 

       190        200        210        220        230        240 
ARTQLAWLKR HLADAKEDYV LVAGHYPVWS IAEHGPTHCL VKKLQPLLVK YGVTAYLCGH 

       250        260        270        280        290        300 
DHNLQYLQDE NGVGYVLSGA GNFMDPSTQH QRSVPNGYLR FHYGAENSLG GFAYLEITPK 

       310        320 
EMTVTYMEAS GKSLFKTRLP KRAKA

O97860 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools