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[1]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
DOI=10.1126/science.287.5461.2185; PubMed=10731132 [NCBI, ExPASy, EBI, Israel, Japan]
Adams M.D.,
Celniker S.E.,
Holt R.A.,
Evans C.A.,
Gocayne J.D.,
Amanatides P.G.,
Scherer S.E.,
Li P.W.,
Hoskins R.A.,
Galle R.F.,
George R.A.,
Lewis S.E.,
Richards S.,
Ashburner M.,
Henderson S.N.,
Sutton G.G.,
Wortman J.R.,
Yandell M.D.,
Zhang Q., ![]()
Chen L.X.,
Brandon R.C.,
Rogers Y.-H.C.,
Blazej R.G.,
Champe M.,
Pfeiffer B.D.,
Wan K.H.,
Doyle C.,
Baxter E.G.,
Helt G.,
Nelson C.R.,
Miklos G.L.G.,
Abril J.F.,
Agbayani A.,
An H.-J.,
Andrews-Pfannkoch C.,
Baldwin D.,
Ballew R.M.,
Basu A.,
Baxendale J.,
Bayraktaroglu L.,
Beasley E.M.,
Beeson K.Y.,
Benos P.V.,
Berman B.P.,
Bhandari D.,
Bolshakov S.,
Borkova D.,
Botchan M.R.,
Bouck J.,
Brokstein P.,
Brottier P.,
Burtis K.C.,
Busam D.A.,
Butler H.,
Cadieu E.,
Center A.,
Chandra I.,
Cherry J.M.,
Cawley S.,
Dahlke C.,
Davenport L.B.,
Davies P.,
de Pablos B.,
Delcher A.,
Deng Z.,
Mays A.D.,
Dew I.,
Dietz S.M.,
Dodson K.,
Doup L.E.,
Downes M.,
Dugan-Rocha S.,
Dunkov B.C.,
Dunn P.,
Durbin K.J.,
Evangelista C.C.,
Ferraz C.,
Ferriera S.,
Fleischmann W.,
Fosler C.,
Gabrielian A.E.,
Garg N.S.,
Gelbart W.M.,
Glasser K.,
Glodek A.,
Gong F.,
Gorrell J.H.,
Gu Z.,
Guan P.,
Harris M.,
Harris N.L.,
Harvey D.A.,
Heiman T.J.,
Hernandez J.R.,
Houck J.,
Hostin D.,
Houston K.A.,
Howland T.J.,
Wei M.-H.,
Ibegwam C.,
Jalali M.,
Kalush F.,
Karpen G.H.,
Ke Z.,
Kennison J.A.,
Ketchum K.A.,
Kimmel B.E.,
Kodira C.D.,
Kraft C.L.,
Kravitz S.,
Kulp D.,
Lai Z.,
Lasko P.,
Lei Y.,
Levitsky A.A.,
Li J.H.,
Li Z.,
Liang Y.,
Lin X.,
Liu X.,
Mattei B.,
McIntosh T.C.,
McLeod M.P.,
McPherson D.,
Merkulov G.,
Milshina N.V.,
Mobarry C.,
Morris J.,
Moshrefi A.,
Mount S.M.,
Moy M.,
Murphy B.,
Murphy L.,
Muzny D.M.,
Nelson D.L.,
Nelson D.R.,
Nelson K.A.,
Nixon K.,
Nusskern D.R.,
Pacleb J.M.,
Palazzolo M.,
Pittman G.S.,
Pan S.,
Pollard J.,
Puri V.,
Reese M.G.,
Reinert K.,
Remington K.,
Saunders R.D.C.,
Scheeler F.,
Shen H.,
Shue B.C.,
Siden-Kiamos I.,
Simpson M.,
Skupski M.P.,
Smith T.J.,
Spier E.,
Spradling A.C.,
Stapleton M.,
Strong R.,
Sun E.,
Svirskas R.,
Tector C.,
Turner R.,
Venter E.,
Wang A.H.,
Wang X.,
Wang Z.-Y.,
Wassarman D.A.,
Weinstock G.M.,
Weissenbach J.,
Williams S.M.,
Woodage T.,
Worley K.C.,
Wu D.,
Yang S.,
Yao Q.A.,
Ye J.,
Yeh R.-F.,
Zaveri J.S.,
Zhan M.,
Zhang G.,
Zhao Q.,
Zheng L.,
Zheng X.H.,
Zhong F.N.,
Zhong W.,
Zhou X.,
Zhu S.C.,
Zhu X.,
Smith H.O.,
Gibbs R.A.,
Myers E.W.,
Rubin G.M.,
Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
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[2]
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GENOME REANNOTATION.
PubMed=12537572 [NCBI, ExPASy, EBI, Israel, Japan]
Misra S.,
Crosby M.A.,
Mungall C.J.,
Matthews B.B.,
Campbell K.S.,
Hradecky P.,
Huang Y.,
Kaminker J.S.,
Millburn G.H.,
Prochnik S.E.,
Smith C.D.,
Tupy J.L.,
Whitfield E.J.,
Bayraktaroglu L.,
Berman B.P.,
Bettencourt B.R.,
Celniker S.E.,
de Grey A.D.N.J.,
Drysdale R.A., ![]()
Harris N.L.,
Richter J.,
Russo S.,
Schroeder A.J.,
Shu S.Q.,
Stapleton M.,
Yamada C.,
Ashburner M.,
Gelbart W.M.,
Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Oregon-R;
DOI=10.1126/science.287.5461.2220; PubMed=10731137 [NCBI, ExPASy, EBI, Israel, Japan]
Benos P.V.,
Gatt M.K.,
Ashburner M.,
Murphy L.,
Harris D.,
Barrell B.G.,
Ferraz C.,
Vidal S.,
Brun C.,
Demailles J.,
Cadieu E.,
Dreano S.,
Gloux S.,
Lelaure V.,
Mottier S.,
Galibert F.,
Borkova D.,
Minana B.,
Kafatos F.C., ![]()
Louis C.,
Siden-Kiamos I.,
Bolshakov S.,
Papagiannakis G.,
Spanos L.,
Cox S.,
Madueno E.,
de Pablos B.,
Modolell J.,
Peter A.,
Schoettler P.,
Werner M.,
Mourkioti F.,
Beinert N.,
Dowe G.,
Schaefer U.,
Jaeckle H.,
Bucheton A.,
Callister D.M.,
Campbell L.A.,
Darlamitsou A.,
Henderson N.S.,
McMillan P.J.,
Salles C.,
Tait E.A.,
Valenti P.,
Saunders R.D.C.,
Glover D.M.;
"From sequence to chromosome: the tip of the X chromosome of D. melanogaster.";
Science 287:2220-2222(2000).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 979-1809.
STRAIN=Berkeley;
TISSUE=Embryo, Larva, and Pupae;
PubMed=12537569 [NCBI, ExPASy, EBI, Israel, Japan]
Stapleton M.,
Carlson J.W.,
Brokstein P.,
Yu C.,
Champe M.,
George R.A.,
Guarin H.,
Kronmiller B.,
Pacleb J.M.,
Park S.,
Wan K.H.,
Rubin G.M.,
Celniker S.E.;
"A Drosophila full-length cDNA resource.";
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
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[5]
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FUNCTION, AND SUBCELLULAR LOCATION.
DOI=10.1091/mbc.E06-03-0239; PubMed=16837550 [NCBI, ExPASy, EBI, Israel, Japan]
Rusten T.E.,
Rodahl L.M.W.,
Pattni K.,
Englund C.,
Samakovlis C.,
Dove S.,
Brech A.,
Stenmark H.;
"Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors.";
Mol. Biol. Cell 17:3989-4001(2006).
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[6]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-755; THR-760 AND SER-1530, AND MASS SPECTROMETRY.
TISSUE=Embryo;
DOI=10.1021/pr700696a; PubMed=18327897 [NCBI, ExPASy, EBI, Israel, Japan]
Zhai B.,
Villen J.,
Beausoleil S.A.,
Mintseris J.,
Gygi S.P.;
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
J. Proteome Res. 7:1675-1682(2008).
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- FUNCTION: Supports the intracellular PIP pool and to a lesser extent, the PI 4,5-P(2) pool. It generates PIP from PI and, to a lesser extent, PI 4,5-P(2) from PI 4-P. There are indications that it phosphorylates the D-5 rather than the D-4 position. Has a role at a late stage in endosome-related membrane trafficking, at a point when signal termination has occurred. Is not required for receptor silencing.
- CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
- COFACTOR: Zinc (By similarity).
- SUBCELLULAR LOCATION: Endosome membrane. Note=Mainly associated with membranes of the late endocytic pathway.
- MISCELLANEOUS: Flies lacking fab1 contain undetectable phosphatidylinositol 3,5-bisphosphate levels, show profound increases in cell and organ size, and die at the pupal stage. Mutant larvae contain highly enlarged multivesicular bodies and late endosomes that are inefficiently acidified. Even though endocytic receptor trafficking is impaired in fab1 mutants, Notch, Wingless, and Dpp signaling is unaffected.
- SIMILARITY: Contains 1 DEP domain.
- SIMILARITY: Contains 1 FYVE-type zinc finger.
- SIMILARITY: Contains 1 PI5K domain.
- SEQUENCE CAUTION:
- Sequence=CAA22949.1; Type=Erroneous gene model prediction;
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 1809 AA [This is the length of the unprocessed precursor] |
Molecular weight: 204635 Da [This is the MW of the unprocessed precursor] |
CRC64: B5A111FAD317B05F [This is a checksum on the sequence] |
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10 20 30 40 50 60
MTSNNQNNSS SHQHLHSPSK LTEFARNFED KPESLFGRVV NKIQNVYNQS YNTVNDISSG
70 80 90 100 110 120
SSSSSSTQPV QVVGKSQFFS DSQTSTAEIA DVETSSQSSV RPQPPTTLSI RTNSETRGTS
130 140 150 160 170 180
TSSNTAAEDS ETSDRVETLP LPTSEANQGR TVSNVLKHIS NIVATKNNND LRNYKDTELQ
190 200 210 220 230 240
RFWMPDSKAK ECYDCSQKFS TFRRKHHCRL CGQIFCSKCC NQVVPGMIIR CDGDLKVCNY
250 260 270 280 290 300
CSKIVLTFLK SSSSEMGQDM QELQQHLSNK LEVQDSGSSL AKHPQMQRAP LPRKTSVGYQ
310 320 330 340 350 360
EERFSSHPTY TTLSIDDRKN ILQQSNSLIT LHEEMQRDLP AQNCGQRLIE FLNSNNKSAN
370 380 390 400 410 420
EVQAVAILNA MLAAGFLEPI VPDPEQMDFD SSLHYKFSKS SSSDTSRTMS PQFEANPHAE
430 440 450 460 470 480
PQPPKSMDQS AEEKEKELEN ELENDRCYTT ATSKLLASYC EHEEQLLAQM LRAHNLDQEW
490 500 510 520 530 540
DKVLQMLCST AANHFKPEHC SNDLMDIRNY VNFKKVPGGR RKDSKIVHGV AFSKNVAHKD
550 560 570 580 590 600
MATHVPFPRI LLLQCPIVYE RIEGKFVTIE TVLLQEKEYL RNVCARIMSF KPNVVLVHKN
610 620 630 640 650 660
VAGIAQDLLR SYEVTLVLDV KLSVMERLSR TLQCDIVSSI ESNITMPKLG YCNDFYIRNY
670 680 690 700 710 720
NGKTLMFFEK LTNPRGYTCL LRGGSNAELT RVKRVASALL FARYNWRLEM SFLLNEFAQP
730 740 750 760 770 780
LSPKPSIFDS KETSPKTETE AELRSKRPII LERKSEDKIT TIVSENVSDF TDPLRASQAE
790 800 810 820 830 840
ALSTSPCAPP VVEALAVEPR YDNRFRTALS STLLSVSPFL TFPLPYLETE QGRKCKLRKL
850 860 870 880 890 900
FPAELYFSKQ WSRTGLERPD SMGDGEAGKS EPGNKENQMQ LLPAHDFVLM KITAPASSRD
910 920 930 940 950 960
IQSKLAEFRS FGGRLPKGKA PMLRPKKKNA EVIQRPQKVS EEQLYKDALD PQNHQRLPVL
970 980 990 1000 1010 1020
FCSFHYNPKG VSSFCKLPML LDMKFYGQYD IMLEQFLQRY CCLFNSMCPS CNLPMLGHVR
1030 1040 1050 1060 1070 1080
RYVHSLGCVH VYLTEDLTRS DPTRIYFTSW CSICNATTPT IPLSDAAKCL SLAKYLEMRF
1090 1100 1110 1120 1130 1140
HGHAYKRRPP STDAEQGGTV CEHSLHRDYV HHFSFRGVGA KFQYTPVEVW ETDLPSLTVQ
1150 1160 1170 1180 1190 1200
LDLPQPFQSA QVQEEIKNFS IKGHEVYNRI HERIADLATE EENSPLVQHL KTMLTHDQFI
1210 1220 1230 1240 1250 1260
FKQKIEIVHT LLTDNRATAY DTSDALAMAR RALAESIELW GPRLQEIEKL TAKQAHHIDS
1270 1280 1290 1300 1310 1320
GTICTEELRP EQVQTADSSK VTTSSLPKEN DPLECPSEDT ETGASNSQTV LDKNFSIDQM
1330 1340 1350 1360 1370 1380
LASTVNVYSD KKSIRKILTQ LLPSGNQVNP LQSPFPAQDH LTLPLGSIPI HVRETDLSSV
1390 1400 1410 1420 1430 1440
IAYSLTSMDY QKAIDEAEAN SNAAHSSPQL KRKIPLAESV SDAEDSPSLS RTSSNTSAAP
1450 1460 1470 1480 1490 1500
NASVPSPATA ASESEEKSKE RIKQPPSPHI TLAFQDHSCQ FQCKIYFARE FDAMRSKSLK
1510 1520 1530 1540 1550 1560
PPKLDKSLYR RLEKSKMREE LRISQSRTGS EMELVRKPSD VGAPRTTEDD SNQEEDARIA
1570 1580 1590 1600 1610 1620
LARSLCKSVQ WEARGGKSGS RFCKTLDDRF VLKEMNSRDM TIFEPFAPKY FEYIDRCQQQ
1630 1640 1650 1660 1670 1680
QQPTLLAKIF GVFRVSVKKK DSFVERSVMV MENLFYGCNI ENKFDLKGSE RNRLVDPSNQ
1690 1700 1710 1720 1730 1740
QGEIVLLDEN LVQMSWSKPL YVLSHSKTVL RDAIQRDSSF LEKNLVMDYS LLVGLDKKNG
1750 1760 1770 1780 1790 1800
VLVLGIIDYI RTFTLDKRVE SIIKGSGILG GKGKDPTVVN PERYKQRFID AMDRYFLTVP
DRWEGLSKV
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O96838 in FASTA format |
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