[1]	NUCLEOTIDE SEQUENCE [MRNA]. Tian L., Tam J.W.O.; "Molecular cloning of thymidylate synthase from Ascaris suum."; Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
PATHWAY: Pyrimidine metabolism; dTTP biosynthesis .
SUBUNIT: Homodimer (By similarity).
SIMILARITY: Belongs to the thymidylate synthase family.

Copyright

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Cross-references

Sequence databases

EMBL

AF099672; AAC97507.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P04818; 1HVY. [HSSP ENTRY / PDB]

ModBase

O96650.

Family and domain databases

InterPro

IPR000398; Thymidylat_synth_C.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.572.10; Thymidylat_synth_C; 1.

PANTHER

PTHR11549:SF2; Thymidylat_synth_C; 1.

Pfam

PF00303; Thymidylat_synt; 1.
Pfam graphical view of domain structure.

PRINTS

PR00108; THYMDSNTHASE.

ProDom

PD001180; Thymidylat_synth; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR03284; thym_sym; 1.

PROSITE

PS00091; THYMIDYLATE_SYNTHASE; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Methyltransferase; Nucleotide biosynthesis; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 294`	`294`	`Thymidylate synthase.`	`PRO_0000140904`
`ACT_SITE`	`176 176`		`By similarity.`

Sequence information

Length: 294 AA [This is the length of the unprocessed precursor]

Molecular weight: 33054 Da [This is the MW of the unprocessed precursor]

CRC64: CDFD4556972A3C50 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MEGANVNEDE RKYLRQIKHI IDEGDKVIDR TGVGTLSLFG LHSTYSLRNG VIPLLTTKRV 

        70         80         90        100        110        120 
YWKGVVEELL WFIKGDTDAK RLSAKGVKIW DANGSREFLD SQGFKDRPEG DLGPIYGFQW 

       130        140        150        160        170        180 
RHFGAEYHGT DADYKGQGVD QLADVIEQIK NNPNSRRIIL NAWNVKDLHQ MALPPCHTLA 

       190        200        210        220        230        240 
QFAVKNGELS CQLYQRSGDM GLGVPFNLAS YGLLTHMIAH VCALKTGFLH HVLGDAHVYL 

       250        260        270        280        290 
NHIDALKEQL SRDPRPFPTV HFEGRIDSID DFTAESIILN GYNPMAPIKM PMAV

O96650 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools