ID   TGM3L_HUMAN             Reviewed;         706 AA.
AC   O95932; Q5JXU4; Q5JXU5; Q719M2; Q719M3; Q9Y4U8;
DT   10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2005, sequence version 3.
DT   04-NOV-2008, entry version 72.
DE   RecName: Full=Protein-glutamine gamma-glutamyltransferase 6;
DE            EC=2.3.2.13;
DE   AltName: Full=Transglutaminase-3-like;
DE            Short=TGase-3-like;
DE   AltName: Full=Transglutaminase Y;
GN   Name=TGM6; Synonyms=TGM3L;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND VARIANT VAL-58.
RC   TISSUE=Lung;
RA   Thomas H., Aeschlimann D.;
RT   "A novel transglutaminase expressed in the nervous system.";
RL   Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=21638749; PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA   Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA   Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA   Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA   Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA   Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA   Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA   Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA   Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA   Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA   Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA   Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
CC   -!- FUNCTION: Catalyzes the cross-linking of proteins and the
CC       conjugation of polyamines to proteins (By similarity).
CC   -!- CATALYTIC ACTIVITY: Protein glutamine + alkylamine = protein N(5)-
CC       alkylglutamine + NH(3).
CC   -!- COFACTOR: Binds 1 calcium ion per subunit (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=Long;
CC         IsoId=O95932-1; Sequence=Displayed;
CC       Name=2; Synonyms=Short;
CC         IsoId=O95932-2; Sequence=VSP_015103, VSP_015104;
CC   -!- SIMILARITY: Belongs to the transglutaminase superfamily.
CC       Transglutaminase family.
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DR   EMBL; AF540969; AAQ10751.1; -; mRNA.
DR   EMBL; AF540970; AAQ10752.1; -; mRNA.
DR   EMBL; AL049650; CAI22576.1; -; Genomic_DNA.
DR   EMBL; AL031678; CAI22576.1; JOINED; Genomic_DNA.
DR   EMBL; AL049650; CAI22577.1; -; Genomic_DNA.
DR   EMBL; AL031678; CAI22577.1; JOINED; Genomic_DNA.
DR   EMBL; AL031678; CAI22900.1; -; Genomic_DNA.
DR   EMBL; AL049650; CAI22900.1; JOINED; Genomic_DNA.
DR   EMBL; AL031678; CAI22901.1; -; Genomic_DNA.
DR   EMBL; AL049650; CAI22901.1; JOINED; Genomic_DNA.
DR   RefSeq; NP_945345.2; -.
DR   UniGene; Hs.452039; -.
DR   HSSP; Q08188; 1L9M.
DR   Ensembl; ENSG00000166948; Homo sapiens.
DR   GeneID; 343641; -.
DR   KEGG; hsa:343641; -.
DR   NMPDR; fig|9606.3.peg.19725; -.
DR   HGNC; HGNC:16255; TGM6.
DR   PharmGKB; PA38098; -.
DR   HOGENOM; O95932; -.
DR   HOVERGEN; O95932; -.
DR   DrugBank; DB00130; L-Glutamine.
DR   NextBio; 98594; -.
DR   ArrayExpress; O95932; -.
DR   CleanEx; HS_TGM6; -.
DR   GermOnline; ENSG00000166948; Homo sapiens.
DR   GO; GO:0008415; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR008958; Transglutaminase_C.
DR   InterPro; IPR013808; Transglutaminase_CS.
DR   InterPro; IPR001102; Transglutaminase_N.
DR   InterPro; IPR002931; Trnsglumase_like.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 3.
DR   Pfam; PF00927; Transglut_C; 2.
DR   Pfam; PF01841; Transglut_core; 1.
DR   Pfam; PF00868; Transglut_N; 1.
DR   SMART; SM00460; TGc; 1.
DR   PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Alternative splicing; Calcium; Metal-binding;
KW   Polymorphism; Transferase.
FT   CHAIN         1    706       Protein-glutamine gamma-
FT                                glutamyltransferase 6.
FT                                /FTId=PRO_0000213715.
FT   ACT_SITE    274    274       By similarity.
FT   ACT_SITE    333    333       By similarity.
FT   ACT_SITE    356    356       By similarity.
FT   METAL       396    396       Calcium (By similarity).
FT   METAL       398    398       Calcium (By similarity).
FT   METAL       445    445       Calcium (By similarity).
FT   METAL       450    450       Calcium (By similarity).
FT   VAR_SEQ     612    625       VLGPAMVGVAVTVE -> RAYPGASGEGLSPV (in
FT                                isoform 2).
FT                                /FTId=VSP_015103.
FT   VAR_SEQ     626    706       Missing (in isoform 2).
FT                                /FTId=VSP_015104.
FT   VARIANT      58     58       M -> V (in dbSNP:rs2076405).
FT                                /FTId=VAR_013250.
SQ   SEQUENCE   706 AA;  79312 MW;  97BBE2043C5FF834 CRC64;
     MAGIRVTKVD WQRSRNGAAH HTQEYPCPEL VVRRGQSFSL TLELSRALDC EEILIFTMET
     GPRASEALHT KAVFQTSELE RGEGWTAARE AQMEKTLTVS LASPPSAVIG RYLLSIRLSS
     HRKHSNRRLG EFVLLFNPWC AEDDVFLASE EERQEYVLSD SGIIFRGVEK HIRAQGWNYG
     QFEEDILNIC LSILDRSPGH QNNPATDVSC RHNPIYVTRV ISAMVNSNND RGVVQGQWQG
     KYGGGTSPLH WRGSVAILQK WLKGRYKPVK YGQCWVFAGV LCTVLRCLGI ATRVVSNFNS
     AHDTDQNLSV DKYVDSFGRT LEDLTEDSMW NFHVWNESWF ARQDLGPSYN GWQVLDATPQ
     EESEGVFRCG PASVTAIREG DVHLAHDGPF VFAEVNADYI TWLWHEDESR ERVYSNTKKI
     GRCISTKAVG SDSRVDITDL YKYPEGSRKE RQVYSKAVNR LFGVEASGRR IWIRRAGGRC
     LWRDDLLEPA TKPSIAGKFK VLEPPMLGHD LRLALCLANL TSRAQRVRVN LSGATILYTR
     KPVAEILHES HAVRLGPQEE KRIPITISYS KYKEDLTEDK KILLAAMCLV TKGEKLLVEK
     DITLEDFITI KVLGPAMVGV AVTVEVTVVN PLIERVKDCA LMVEGSGLLQ EQLSIDVPTL
     EPQERASVQF DITPSKSGPR QLQVDLVSPH FPDIKGFVIV HVATAK
//