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[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ENZYME REGULATION, AND TISSUE SPECIFICITY.
DOI=10.1074/jbc.274.19.13619; PubMed=10224133 [NCBI, ExPASy, EBI, Israel, Japan]
Spiegelberg B.D.,
Xiong J.-P.,
Smith J.J.,
Gu R.F.,
York J.D.;
"Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate.";
J. Biol. Chem. 274:13619-13628(1999).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=B-cell;
Yenush L.,
Gil-Mascarell M.,
Serrano R.,
Rodriguez P.L.;
"Hydrolysis of inositol-1,4-bisphosphate by human and yeast lithium sensitive 3'-phosphoadenosine 5'-phosphate nucleotidases.";
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Skeletal muscle;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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- FUNCTION: Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.
- CATALYTIC ACTIVITY: Adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate.
- COFACTOR: Magnesium.
- ENZYME REGULATION: Uncompetitive inhibition by micromolar concentrations of lithium. Competitive inhibition by inositol 1,4-bisphosphate.
- ALTERNATIVE PRODUCTS:
2 named isoforms [FASTA] produced by alternative splicing.
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| Name | 2 |
| Isoform ID | O95861-2 |
| Note: No experimental confirmation available. |
| Features which should be applied to build the isoform sequence: VSP_009937. |
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- TISSUE SPECIFICITY: Highly expressed in kidney, liver, pancreas and heart. Detected at lower levels in brain, placenta, lung and skeletal muscle.
- SIMILARITY: Belongs to the inositol monophosphatase family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 308 AA [This is the length of the unprocessed precursor] |
Molecular weight: 33392 Da [This is the MW of the unprocessed precursor] |
CRC64: A5952F5E31C8CFCB [This is a checksum on the sequence] |
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10 20 30 40 50 60
MASSNTVLMR LVASAYSIAQ KAGMIVRRVI AEGDLGIVEK TCATDLQTKA DRLAQMSICS
70 80 90 100 110 120
SLARKFPKLT IIGEEDLPSE EVDQELIEDS QWEEILKQPC PSQYSAIKEE DLVVWVDPLD
130 140 150 160 170 180
GTKEYTEGLL DNVTVLIGIA YEGKAIAGVI NQPYYNYEAG PDAVLGRTIW GVLGLGAFGF
190 200 210 220 230 240
QLKEVPAGKH IITTTRSHSN KLVTDCVAAM NPDAVLRVGG AGNKIIQLIE GKASAYVFAS
250 260 270 280 290 300
PGCKKWDTCA PEVILHAVGG KLTDIHGNVL QYHKDVKHMN SAGVLATLRN YDYYASRVPE
SIKNALVP
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O95861 in FASTA format |
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