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UniProtKB/Swiss-Prot entry O95848


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NUD14_HUMAN
Primary accession number O95848
Secondary accession number Q86SJ8
Integrated into Swiss-Prot on March 1, 2004
Sequence was last modified on March 1, 2004 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 52)
Name and origin of the protein
Protein name Uridine diphosphate glucose pyrophosphatase
Synonyms UDPG pyrophosphatase
UGPPase
EC 3.6.1.45
Nucleoside diphosphate-linked moiety X motif 14
Nudix motif 14
Gene name
Name: NUDT14
Synonyms: UGPP
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1006/geno.1999.6045; PubMed=10662552 [NCBI, ExPASy, EBI, Israel, Japan]
Deng Y., Madan A., Banta A.B., Friedman C., Trask B.J., Hood L., Li L.;
"Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene.";
Genomics 63:133-138(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, SUBCELLULAR LOCATION, AND SUBUNIT.
TISSUE=Thyroid;
DOI=10.1042/BJ20021140; PubMed=12429023 [NCBI, ExPASy, EBI, Israel, Japan]
Yagi T., Baroja-Fernandez E., Yamamoto R., Munoz F.J., Akazawa T., Hong K.S., Pozueta-Romero J.;
"Cloning, expression and characterization of a mammalian Nudix hydrolase-like enzyme that cleaves the pyrophosphate bond of UDP-glucose.";
Biochem. J. 370:409-415(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature01348; PubMed=12508121 [NCBI, ExPASy, EBI, Israel, Japan]
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.;
"The DNA sequence and analysis of human chromosome 14.";
Nature 421:601-607(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF111170; AAD15563.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB087802; BAC65455.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL512355; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
BC041584; AAH41584.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_803877.2; -.
UniGene Hs.526432
3D structure databases
ModBase O95848.
Protein-protein interaction databases
IntAct O95848; -.
Organism-specific databases
H-InvDB HIX0026628; -.
HGNC HGNC:20141; NUDT14.
GenAtlas NUDT14.
MIM 609219; gene. [NCBI / EBI]
PharmGKB PA134971372; -.
GeneCards O95848.
Gene expression databases
ArrayExpress O95848; -.
CleanEx HS_NUDT14; -.
GermOnline ENSG00000183828; Homo sapiens.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR004385; NDP_pyrophos.
IPR000086; NUDIX_hydrolase_core.
Graphical view of domain structure.
Gene3D G3DSA:3.90.79.10; NUDIX_hydrolase; 1.
Pfam PF00293; NUDIX; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00052; NDP_pyrophos; 1.
PROSITE PS00893; NUDIX; FALSE_NEG.
BLOCKS O95848.
ProtoNet O95848.
Genome annotation databases
Ensembl ENSG00000183828; Homo sapiens. [Contig view]
GeneID 256281; -.
KEGG hsa:256281; -.
NMPDR fig|9606.3.peg.10277; -.
Phylogenomic databases
HOGENOM O95848; -.
HOVERGEN O95848; -.
Other
NextBio 92764; -.
SOURCE NUDT14; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Hydrolase; Magnesium.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   222  222     Uridine diphosphate glucose pyrophosphatase. PRO_0000057113
MOTIF   111   129  19     Nudix box. 
Sequence information
Length: 222 AA [This is the length of the unprocessed precursor] Molecular weight: 24118 Da [This is the MW of the unprocessed precursor] CRC64: FB1DFA40A67E72B6 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MERIEGASVG RCAASPYLRP LTLHYRQNGA QKSWDFMKTH DSVTVLLFNS SRRSLVLVKQ 

        70         80         90        100        110        120 
FRPAVYAGEV ERRFPGSLAA VDQDGPRELQ PALPGSAGVT VELCAGLVDQ PGLSLEEVAC 

       130        140        150        160        170        180 
KEAWEECGYH LAPSDLRRVA TYWSGVGLTG SRQTMFYTEV TDAQRSGPGG GLVEEGELIE 

       190        200        210        220 
VVHLPLEGAQ AFADDPDIPK TLGVIFGVSW FLSQVAPNLD LQ 

O95848 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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NPSA logo NPSA Sequence analysis tools

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