ID   LSM8_HUMAN              Reviewed;          96 AA.
AC   O95777;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   16-DEC-2008, entry version 78.
DE   RecName: Full=U6 snRNA-associated Sm-like protein LSm8;
GN   Name=LSM8;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE, AND PARTIAL PROTEIN SEQUENCE.
RX   MEDLINE=99452783; PubMed=10523320; DOI=10.1093/emboj/18.20.5789;
RA   Achsel T., Brahms H., Kastner B., Bachi A., Wilm M., Luehrmann R.;
RT   "A doughnut-shaped heteromer of human Sm-like proteins binds to the
RT   3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in
RT   vitro.";
RL   EMBO J. 18:5789-5802(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22737999; PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PROTEIN SEQUENCE OF 2-11; 29-44 AND 88-96, CLEAVAGE OF INITIATOR
RP   METHIONINE, ACETYLATION AT THR-2, AND MASS SPECTROMETRY.
RC   TISSUE=B-cell lymphoma;
RA   Bienvenut W.V.;
RL   Submitted (JUL-2005) to UniProtKB.
CC   -!- FUNCTION: Binds specifically to the 3'-terminal U-tract of U6
CC       snRNA.
CC   -!- SUBUNIT: LSm subunits form a heteromer with a donut shape.
CC   -!- INTERACTION:
CC       Q86Y22:COL23A1; NbExp=1; IntAct=EBI-347779, EBI-373279;
CC       Q9UBU7:DBF4; NbExp=1; IntAct=EBI-347779, EBI-372690;
CC       Q9NPI6:DCP1A; NbExp=1; IntAct=EBI-347779, EBI-374238;
CC       Q01780:EXOSC10; NbExp=1; IntAct=EBI-347779, EBI-358236;
CC       Q8N5J2:FAM63A; NbExp=1; IntAct=EBI-347779, EBI-372322;
CC       Q86UX7:FERMT3; NbExp=1; IntAct=EBI-347779, EBI-373158;
CC       P78347:GTF2I; NbExp=1; IntAct=EBI-347779, EBI-359622;
CC       P38935:IGHMBP2; NbExp=1; IntAct=EBI-347779, EBI-372250;
CC       Q8IU57:IL28RA; NbExp=1; IntAct=EBI-347779, EBI-373215;
CC       Q96AB3:ISOC2; NbExp=1; IntAct=EBI-347779, EBI-372799;
CC       Q9NZM3:ITSN2; NbExp=1; IntAct=EBI-347779, EBI-308689;
CC       Q9Y597:KCTD3; NbExp=1; IntAct=EBI-347779, EBI-373299;
CC       Q9Y333:LSM2; NbExp=3; IntAct=EBI-347779, EBI-347416;
CC       P62310:LSM3; NbExp=2; IntAct=EBI-347779, EBI-348239;
CC       Q9Y4Z0:LSM4; NbExp=2; IntAct=EBI-347779, EBI-372521;
CC       P62312:LSM6; NbExp=1; IntAct=EBI-347779, EBI-373310;
CC       Q9UK45:LSM7; NbExp=1; IntAct=EBI-347779, EBI-348372;
CC       P42898:MTHFR; NbExp=1; IntAct=EBI-347779, EBI-372435;
CC       Q16342:PDCD2; NbExp=1; IntAct=EBI-347779, EBI-359462;
CC       P52209:PGD; NbExp=1; IntAct=EBI-347779, EBI-372761;
CC       P83731:RPL24; NbExp=1; IntAct=EBI-347779, EBI-353146;
CC       Q99719:SEPT5; NbExp=1; IntAct=EBI-347779, EBI-373345;
CC       P62314:SNRPD1; NbExp=1; IntAct=EBI-347779, EBI-372177;
CC       P37837:TALDO1; NbExp=1; IntAct=EBI-347779, EBI-1056712;
CC       Q9BV44:THUMPD3; NbExp=1; IntAct=EBI-347779, EBI-373253;
CC       Q92900:UPF1; NbExp=1; IntAct=EBI-347779, EBI-373471;
CC   -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC   -!- SIMILARITY: Belongs to the snRNP Sm proteins family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AF182294; AAD56232.1; -; mRNA.
DR   EMBL; AC006389; AAD15542.1; -; Genomic_DNA.
DR   EMBL; BC002742; AAH02742.1; -; mRNA.
DR   EMBL; BC022440; AAH22440.1; -; mRNA.
DR   RefSeq; NP_057284.1; -.
DR   UniGene; Hs.657737; -.
DR   HSSP; O26745; 1JBM.
DR   IntAct; O95777; 26.
DR   PhosphoSite; O95777; -.
DR   PeptideAtlas; O95777; -.
DR   PRIDE; O95777; -.
DR   Ensembl; ENSG00000128534; Homo sapiens.
DR   GeneID; 51691; -.
DR   KEGG; hsa:51691; -.
DR   GeneCards; GC07P117611; -.
DR   H-InvDB; HIX0007025; -.
DR   HGNC; HGNC:20471; LSM8.
DR   MIM; 607288; gene.
DR   PharmGKB; PA134930584; -.
DR   HOGENOM; O95777; -.
DR   HOVERGEN; O95777; -.
DR   NextBio; 55698; -.
DR   ArrayExpress; O95777; -.
DR   CleanEx; HS_LSM8; -.
DR   GermOnline; ENSG00000128534; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR   GO; GO:0030529; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0017070; F:U6 snRNA binding; NAS:UniProtKB.
DR   GO; GO:0000398; P:nuclear mRNA splicing, via spliceosome; NAS:UniProtKB.
DR   InterPro; IPR006649; Euk_arc_LSM_core.
DR   InterPro; IPR001163; LSM_snRNP_core.
DR   Pfam; PF01423; LSM; 1.
DR   ProDom; PD020287; snRNP; 1.
DR   SMART; SM00651; Sm; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Direct protein sequencing; mRNA processing;
KW   mRNA splicing; Nucleus; Ribonucleoprotein; RNA-binding.
FT   INIT_MET      1      1       Removed.
FT   CHAIN         2     96       U6 snRNA-associated Sm-like protein LSm8.
FT                                /FTId=PRO_0000125582.
FT   MOD_RES       2      2       N-acetylthreonine.
SQ   SEQUENCE   96 AA;  10403 MW;  15D26E6B75AA2EE1 CRC64;
     MTSALENYIN RTVAVITSDG RMIVGTLKGF DQTINLILDE SHERVFSSSQ GVEQVVLGLY
     IVRGDNVAVI GEIDEETDSA LDLGNIRAEP LNSVAH
//